Background: Betel habit is a hereditary tradition from the ancestors of the Batak-Karo tribe, Indonesia. Karo people believe that betel habit is their unifier. The betel process begins with concocting a mixture of ingredients such as betel leaf, lime, gambier, areca nut, and with/ without tobacco addition, then chewed slowly. Our previous study showed that gambier extracts (Uncaria gambier Roxb), can reduce blood glucose levels(BGL) in type 2 diabetes mellitus (T2DM)patients. This study aimed to analyze whether the habit of chewing betel can affect BGL in the Karo ethnic community in the Karo district.Methods: In total, 48 participants from the Karo community were divided into 4 groups (n=12 per group), namely: I. non-T2DM participants without betel habits; II. non-T2DM participants with betel habit; III. T2DM participants without betel habit and IV. T2DM participants with betel habit. The sampling technique was consecutive sampling. Data were collected by interviews and blood sampling (fasting and 2 hours postprandial (2hPP)). The collected data analyzed by paired t-test, Independent sample t-test, Wilcoxon, and Mann-Whitney with a significance level of p-value <0.05.Results: This study showed that fasting BGL condition in group-I compared to group II (84.33±12.32 vs 81.00±4.84) mg/dl and group-III compared to group-IV (196.25±104.81 vs 150.00±42.45) mg/dl had no significant difference. Also, the BGL of 2hPP condition in group-I compared to group-II (111.25 ±22.62 vs 108.33±18.99) mg/dl, and group-III compared to group-IV (314.92±128.97 vs 229.25±58.26) mg/dl, in statistically there was no difference (p>0.05). Although the data showed that group-III was higher than group-IV.Conclusions: This study concludes that with/without betel habits affect blood sugar levels in type 2 diabetes subjects (Groups III and IV).
Read full abstract