Herbal Cream Research Articles

Curcumin Nanoparticles Incorporated Kumkumati Topical Agent for Gingival Depigmentation- An in Vitro Assessment of Antioxidant Activity

Background: To date, no topical herbal formulations are available for the depigmentation of gingiva. The current study aims to formulate the herbal topical cream with curcumin nanoparticles incorporated into kumkumati oil followed by its assessment of antioxidant activity.Materials and Method: 0.5mg of curcumin nanoparticles were mixed with one ml of dimethyl sulphoxide in a vortex mixture. To this five ml of kumkumati oil and 5mg of carbapol were added and mixed until the acquisition of creamy consistency. This was tested for antioxidant activity using a DPPH assay.Result: The DPPH inhibition % of 25 μl, 50 μl, and 100 μl are 35.64 ± 0.32, 41.45 ± 0.44, 84.29 ± 0.56 respectively. This is comparable to the standard ascorbic acid which shows antioxidant activity of 98.79 ± 0.45.Conclusion: The formulated material is shown to possess an increased antioxidant activity and thus can be used as a supplemental topical cream in post-surgical/laser gingival depigmentation periods to prevent repigmentation.

Formulation and Evaluation of Herbal Footcream

Skin diseases are numerous and a frequently occurring health problem affecting all ages from the neonates to the elderly and cause harm in number of ways. If the cracks in the heels are deep, they can be painful, hurting when a person stands up, and they may sometimes bleed. Some wild plants and their parts are frequently used to treat these diseases. Herbal crack cream contains the extracts of the plantconsists of five ingredients viz., extract of Daruharida (Berberisaristata DC.), Pashanbheda (Bergenialigulata (Wall.) Engl.), Jivanti (Leptadeniareticulata W. & A.), kampilak (Mallotusphilippensis Muell.-Arg.), Manjistha (Rubiacordifolia Linn.) were used to prepare Herbal crack cream. The main objective of the research work was to prepare and evaluate Herbal crack cream and the results showed that Herbal crack cream passeall Parameters related to cream and TLC of formulated cream and extract showed that the tannins, flavonoids and alkaloids were found to be present in mentioned medicinal plants. These days, skin conditions are a major cause of illness for people of all ages. If someone has a crack in their foot's heel, it hurts and is quite uncomfortable. Environmental factors contribute to the growth of germs and fungi on human skin. This factor is taken into account when creating HERBALFOOTCREAM. That cream's function is to hydrate the heel, and its emulsion is w/o type (cold cream). Cold cream works by producing an oily coating on the skin that aids in reducing water loss from the skin to the environment. Water serves to hydrate and refresh the skin while beeswax and cocoa butter work as emollients, which aid to soften and smooth the skin. The key ingredient in these formulations is argan oil, which has vitamin E and is healthy for the skin since it hydrates. Neem extract also has antibacterial and antifungal properties. Lemongrass essential oil is used in fragrances. This cream is homogeneous, spread sreadily, and is naturally fatty. This is W/O emulsion and with anacidic pH (within the range of skin pH). There was no phase separation in this cream. • The main aim of our research was to develop on anti-cracked heels cream formulation consisting of hedychium spicatum, aleo bar, badensis azodirachta indica for the treatment of cracked heels. Skin diseases are numerous and frequently occurring health problem affecting all age from neonate to the elderly and cause harm in number of ways. • The skin is external exposure of the body. The ageing is most visible on the skin. Nowadays, premature ageing is a big complication in the world because of the changes in an environment. Feet is important part of body; they suffer from many frictions. The lack of oil gland in the feet skin which results into very dry skin. External penetration of dirt, fungus, bacteria cause cuts and wounds. Bacterial decomposition is also occurred in foot give bad odour. For these purpose herbal foot cream is prepared. • This herbal foot cream is prepared from Argan oil (good for dry skin), Neem extract (antibacterial & antifungal effects), Aloe vera extract (for hydration) and lemongrass oil (fragrance). Other than synthetic compound, herbs have more effective, low cost, more availability, and less side effects. Here, ARGAN OIL have good property which give protection to the skin and lemongrass oil is having a good fragrance. Argan oil contains vitamin E which is known as anti-inflammatory agent in skin and several studies proves that vit E is good in seal up the cracks caused by dryness..

Formulation, Evaluation and Medicinal Properties of Medicated Herbal Cream Containing Extract of Tridax Procumbens

At present, herbal medicine has a great impact on human health and diseases herbal medicine plays an important role in general aspects such as economy and medicine. The use of this herbal medicine is increasing day by day due to its quality, efficacy and safety. The present study explored a novel formulation containing extracts of Tridax procumbens, Ficus religiosa, Azadirachta indica and Curcuma longa in cream form (O/W). The formulation was characterized by determining the pharmaceutical properties such as pH, appearance, viscosity, spreadability, etc. The chemical constituents such as carbohydrates, alkaloids, steroids, etc. were detected using identification assays. The cream formulation was designed using excipients such as stearyl alcohol, beeswax, sorbitol monooleate, methylparaben, propylparaben and liquid paraffin. Compared with the control drug, the herbal drug was found to be safer. While allergy medications are associated with some side effects, the formulation of cream is much better than other formulations in terms of absorption and penetration of the active ingredient in the tropics.

Evaluation of wound healing activities of Vitex doniana (Black Plum) ethanol fruit extract

In this study, the folkloric use of Vitex doniana fruit extract for the treatment of wounds was evaluated. The mesocarps of the fresh fruits were removed, oven-dried at 40°C and pulverized. The powdered material (800 g), was exhaustively macerated in 80 % ethanol, filtered and dried in a water bath at 40°C. Phytochemical screening and acute dermal toxicity of the extract were investigated. Herbal ointments (10 and 50 %w/w) were formulated using soft paraffin base. The wound-healing effect of the extract was carried out using twenty albino rats divided into four groups (n=5). Groups I (soft paraffin) and II (10 %w/w Povidone-iodine) served as negative and positive controls, respectively. Groups III and IV were topically treated with 10 %w/w and 50 %w/w of the herbal ointment respectively. Treatments and wound grading were assessed once daily and every 4 days, respectively, as well as the timeframe for percentage wound contraction and epithelialization Both the 10 %w/w and 50 %w/w herbal ointments exhibited a concentration-related significant (P<0.05) wound contraction when compared to the control. Epithelialization period of 50 %w/w extract was less than that of the standard drug. The wound closure area of 50 %w/w extract was >positive control >10 %w/w extract > negative control. Histological study of the wounds on the 16th day indicated no sign of dermal toxicity. Some secondary metabolites such as alkaloids and tannins were present. In conclusion, the folkloric use of the fruit extract of V. doniana for the treatment of wounds may therefore be justified

Formulation Development, Evaluation and Anticandidal Screening of Herbal Cream of Trianthema portulacastrum Linn.

Trianthema portulacastrum, commonly known as black pigweed (E) and patharchata (H) belongs to the family Lamiaceae is a flowering medicinal pants. The plant contains various bioactive compounds such as trianthenol, leptormol, cinnamic acid, beta cyanin and ecdysterone. Traditionally, almost every part of the plant is used for the treatment of inflammation, fungal infection, pain, liver disorders, etc. In the present study, hydroalcoholic extract of leaves of Trianthema portulacastrum was taken to formulate herbal cream in three different batches, i.e., C-I, C-II and C-III, using different concentrations of the extract and prepared cream. Also, the anti-candidal activity of the herbal cream was determined in the fungus Candida albicans. The results obtained indicated that the herbal cream containing hydroalcoholic extract of the selected plant possesses significant anti-candidal activity and hence it may used in the treatment of fungal infection.

Development and Assessment of a Multipurpose Herbal Cream With Moringa oleifera Lam.

Moringa oleifera Lam. (Moringaceae) is an indigenous tree extensively used as a nutrient and an antioxidant. In addition to its medicinal attributes, it possesses a promising role in moisturizing and cleansing the skin. Our study aims to formulate an herbal cream from Moringa oil and evaluate its antimicrobial and anti-inflammatory activity. In the present study, Moringa oil was extracted from the seed kernels and formulated into an herbal cream, and the antimicrobial and anti-inflammatory activity was evaluated. Among the three formulations M1, M2, and M3, the formulation M1 was homogenous, more stable, and non-greasy with constant pH. M1 was subjected to further antimicrobial studies and anti-inflammatory studies by the agar-well diffusion technique and albumin denaturation assays, respectively. M. oleifera seed kernel oil cream exhibited the highest antibacterial effect against Staphylococcus aureus and Escherichia coli, and the results were compared to the standard gentamycin. Moreover, M1 showed remarkable anti-inflammatory activity with an IC50 value of 124.5 μg/mL. The results show that the formulated cream will be efficient in its multipurpose activity. The current study validates the antibacterial and anti-inflammatory potential of M. oleifera seed kernel oil cream.

Formulation and standardization of calendula officinalis for wound healing

The treatment alternatives are accessible for the administration of most kinds of wounds which intense just as incessant. One operator that has been utilized for a long time for the treatment of dermatological issue and has a numerous quantity of pharmacological activities that are valuable to wound mending that is Calendula officinalis, or pot marigold. Home grown plants give a rich source to social insurance to forestall and treat diverse neurotic states. Calendula officinalis, the pot marigold, normal marigold or Scotch marigold, is a plant of the family Asteraceae. The fundamental synthetic segments found in the flowers are saponins, triterpenes, liquor triterpenes, unsaturated fat esters, carotenoids, flavonoids, coumarines, basic oils, hydrocarbons, and unsaturated fats. Calendula officinalis is a plant that has numerous pharmacological activities like injury mending, aggravation, eye disease, menstrual period issues, ulcer, stomach upset etc. In this investigation, the ethanolic extract methodology is done to acquire the concentrate of calendula officinalis herb just as the tender Thin Layer Chromatography profile of calendula officinalis leaf, blossom and stamps of the plant. This exploratory examination will uncover that calendula officinalis introduced calming properties acting in a positive manner on the provocative of the mending procedure. Extractive value and Ash value also determine the quality of the crude drug and that crude drug ethanolic extract use for the formulation of herbal cream and further evaluation process to be used to test calendula officinalis extract ethanolic herbal cream.

Formulation and Evaluation of Herbal Cream for Depigmentation

Pigmentation is the process in which the skin pigments are entirely gets tanned and turns into black color. Exposure to ultraviolet radiation is produce selective effects for vitamin D synthesis, which causes melanin synthesis and pigmentation. Skin pigmentation is nowadays becoming a major problem. Due to this we used depigmenting agents which makes skin fairer. In present study we used the herbal materials which are having the anti-inflammatory and anti-oxidant activity which helps to reduce pigmentation. So, to overcome from the skin pigmentation we made the herbal cream which having a such type ingredients that which helps to reduce pigmentation and makes skin fair. For reduction of pigmentation, we formulated herbal cream by using Papaya Pulp, Aloe Vera, Pomegranate Peel Powder as well as Orange Peel Powder. These ingredients can reduce pigmentation by inhibiting tyrosine which is responsible for melanin secretion. The daily use of our herbal cream can reduce melanin quickly.

A Review on the Formulation and Evaluation of Herbal Cold Creams Incorporating Natural Oils

Herbal cold creams, formulated with natural oils, have emerged as a popular choice in the cosmetic industry due to their natural composition, enhanced safety profile, and potential therapeutic benefits. These emulsions provide a cooling sensation upon application and offer advantages such as moisturizing, nourishing, and protecting the skin. The physiology of the skin, the mechanism of action of topical formulations, and the ideal properties of herbal cold creams play a crucial role in their formulation and effectiveness. Natural oils, such as neem, coconut, almond, olive, and sesame oil, enhance the therapeutic potential of cold creams by providing moisturizing, anti-inflammatory, antimicrobial, and anti-aging properties. Herbal cold creams can be formulated as oil-in-water (O/W) or water-in-oil (W/O) emulsions, each with its unique characteristics. The formulation process involves careful consideration of ingredient selection, emulsifier choice, preservation, and manufacturing methods. Evaluation parameters, including pH measurement, irritancy test, spreadability, viscosity, and dilution test, are essential to ensure the quality, stability, and efficacy of the formulated creams. The growing trend towards herbal cosmetics highlights the need for further research and development to create innovative, safe, and effective herbal cold cream formulations that cater to the diverse needs of consumers while adhering to regulatory requirements

The Therapeutic Effect of Shirvan Herbal Ointment on Human Cutaneous Leishmaniasis Compared with Glucantime.

Cutaneous leishmaniasis (CL) infection is caused by the Leishmania major (L. major) parasite and affects 1.5 to 2 million people worldwide each year. Although research into vaccines and antiparasitic drugs has been somewhat successful, their adverse effects include high toxicity, prolonged regeneration, and scarring. This has highlighted the importance of research to replace natural products with antibacterial and antioxidant properties, such as vegetable extracts and oils. Since, the anti-leishmaniasis effect of each of the components of Shirvan herbal ointment (aloe vera, Brazembel, Nigella sativa, propolis, lavender, and olive oil) has been separately studied and confirmed, it seems that the combination of these components can have an increasing anti-leishmanial effect to treat CL. Therefore, this study investigated the therapeutic impact of Shirvan herbal ointment on Iranian patients with leishmaniasis in comparison with glucantime (meglumine). Sixty patients with leishmaniasis were divided into the control and test groups. The control and test groups received intralesional glucantime and Shirvan herbal cream (two times daily), respectively. The size mean of the lesion was 51.5 ± 32.5 before and 11.11 ± 16.28 after treatment in the control group and 50.8 ± 31.2 before and 0.0 ± 0.0 after treatment in the test group. In addition, the period mean of treatment was 43.9 ± 14.4 days and 30.5 ± 7.4 days in the control and test groups, respectively. There was a significant difference in lesion size between the two groups after treatment. Data suggested that Shirvan herbal ointment can be an alternative drug in the treatment of human CL.

Wound Healing Effect of Furfural and Pentadecanal from Lagerstroemia speciosa (L.) Pers Acetone Flower extracts against Haemadipsa sylvestris Bite

Health professionals working in rural areas where leech infestation is common should be aware that people are at risk for leech bites. The bite develops infected and wounds or ulcers maybe suffer a reaction to an allergen.The experimental plant Lagerstroemia speciosa is commonly called as Queen crape myrtle.Medicinal plants as effective and affordable treatments for cutaneous wounds.The objective of the present study was to investigate the wound healing effect of acetone flower extract of L. speciosaagainst Haemadipsasylvestris bite.Group I is control they didn’t receive any drug treatment, Group II and III received commercial ointment Betadine and Herbal ointment, respectively. Group IV and V are the topical application of LAFE 1% and 2% formulated ointments. The results revealed that the topically applied herbal ointment treated groups had rate of wound contraction 94.4%. The topically applied LAFE 1% and LAFE 2% treated groups had rate of wound contraction 94.5% and 95.3% (P<0.05) respectively at day 21. The present research finds the LAFE1% treated group has equal contraction to herbal ointment applied group and LAFE2% treated group has highest contraction rate compared to control. The study revealed that the acetone flower extract of the L. speciosa was capable of promoting wound healing and functional recovery in a dose-dependent way.

Therapeutic potential of wild rare plant-derived herbal ointment: a promising intervention for managing chronic dermatological conditions

IntroductionChronic skin conditions have become a significant global healthcare issue, necessitating the development of novel therapeutic approaches. This study investigates the medicinal properties of ABBA Herbal Ointment, derived from the wild plant Cymbopogon schoenanthus ssp. proximus. Introduced in 2001, this ointment contains natural ingredients such as Aloe vera, jojoba oil, and calendula, extracted from desert medicinal plants. It has demonstrated swift and conclusive efficacy in treating chronic skin conditions. Clinically verified and patented in Gulf Cooperation Council (GCC) countries (Patent Number: GC 0001218), its therapeutic potential is supported by extensive research conducted by three French laboratories. MethodsThe traditional method is used to produce the ointment from the plant extract. To make the ointment, the extracted plant chlorophyll was homogenised with olive oil and natural beeswax. To further validate the therapeutic potential of the ointment, in vitro occlusive tests were performed to assess its efficacy on human skin, with results observed after 48 hours. In this study, 24 volunteers participated, of which two discontinued. ResultsThe topical application of the ointment shows no side effects, and further trials demonstrate its beneficial effects in managing chronic skin diseases. ConclusionABBA Herbal Ointment, derived from the rare wild plant C. schoenanthus ssp. proximus, shows significant potential as an effective treatment for chronic dermatological conditions. The study supports the ointment's efficacy and safety, aligning with the goal of developing novel therapeutic approaches for chronic skin diseases.

ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITIES OF THE LEAVES OF ACALYPHA WILKESIANA MUELL. ARG. (EUPHORBIACEAE) FORMULATED AS HERBAL CREAM

The use of some traditional creams in Nigeria is associated with negative outcomes. In order to tackle this problem, we conducted a study on the antibacterial and anti-inflammatory characteristics of Acalypha wilkesiana leaves, which were utilized in the creation of a herbal cream. Standard methods were employed to conduct analytical procedures for the analysis of the phytochemical and chromatographic content of A. wilkesiana leaves. The anti-inflammatory efficacy of the unrefined ethanol extract was assessed using the egg albumin technique, throughout a dosage range of 15.6 to 500 mg/ml. The effectiveness of the herbal cream and the raw ethanol extract of A. wilkesiana in killing specific bacteria were evaluated. A comprehensive evaluation was carried out to determine the physicochemical characteristics of the herbal cream formulation using appropriate methodologies. The phytochemical examination of A. wilkesiana which gave a yield of 12.6 % indicated the existence of alkaloids, tannins, and saponins. The anti-inflammatory properties of the crude extract derived from A. wilkesiana had a comparable effect to that of aspirin, a commonly prescribed medicine at doses of 125, 250 and 500 mg/kg. The herbal cream (25.5 ± 0.22) and crude extract (19.5 ± 0.01) had the greatest antibacterial effectiveness against Candida albicans at 200 mg/ml. The physicochemical examination of the cream that was created: pH (5.6 ± 0.64); consistency (5 mm); viscosity (22 x 106 cps); spreadability (36 g.cm/sec); Extrudability (510 gm) showed similarities to the commercially available Gentamycin cream. The herbal cream containing A. wilkesiana has demonstrated substantial promise and could function as a practical alternative to traditional creams for treating skin infections.

Formulation and Evalution of Polyherbal Ointment for Wound Healing and Anti-Microbial Activity

AIM: Formulation And Evaluation Of Poly Herbal Ointment For Wound Healing And Anti-Microbial Activity Objective: Any physical harm involving tearing, cutting, or puncturing the skin is called a wound.. Numerous medications derived from plants have been shown to speed up the healing of various wound types. The goal of the current study was to create a herbal formulation with herbs that have been shown to improve cell migration and proliferation as well as reduce infection and inflammation and speed up the healing process. The use of herbal medicines and interest in them has grown significantly in recent years, even in places with access to contemporary medical care. Because medicinal plants are the richest source of plant-derived compounds and herbal medicines, there has been a recent surge in interest in these products due to their wide range of applications. MATERIAL AND METHOD: The goal of this work is to manufacture and assess an ointment made of extracts from turmeric (Curcumalonga) and neem (Azadirachta indica).The maceration process was utilized to create the ethanolic extracts.After preparing the ointment base, the extract was incorporated into it using the levigation procedure to formulate the ointment. Its physicochemical properties, such as color, odor, pH, spreadability, extrudability, consistency, diffusion studies, solubility, and washability, were assessed once the formulation was finished. Additionally, the formulation's stability at different temperature circumstances was assessed, and the results of the diffusion, spreadability, and irritancy studies remain unchanged. Thus, it might develop into a medium for utilizing the therapeutic qualities of turmeric and neem in an easy-to-use dose form

The Healing Power of Nature: Exploring Herbal Ointments for Skin Wellness

The Healing Power of Nature: Exploring Herbal Ointments for Skin Wellness

Novel multi-purpose herbal topical formulation

The commercial need for herbal formulations is increasing now a days as natural remedies are more favored in the belief that they are safer with fewer side effects than synthetic ones. Therefore, it is rational to develop a multipurpose herbal cream that is free from toxic side effects, safe and effective with better patient compliance as compare to allopathic preparations. The present research work related to a multipurpose herbal cream was formulated and subjected to various evaluation parameters, and the findings obtained were evaluated for the limits. The herbal ingredients used to develop the herbal cream comprises aloe vera, Neem oil, turmeric, and rose water. The novel formulations were evaluated for various physicochemical parameters, including appearance, emulsion, pH, texture, homogeneity, irritancy, SPF, antimicrobial studies and identification of constituents. Among all the prepared creams both F1 & F2 were observed as the best formulations. The present research work comprises assessing the moisturizing ability and skin protective ability of the formulated multipurpose herbal topical cream.

Effect of a topical traditional Chinese herbal medicine on skin microbiota in mouse model of atopic dermatitis

This study aims to explore the impact of the herbal ointment Chushi Zhiyang Ruangao (CSZYRG) on the skin's microecological environment in a mouse model of atopic dermatitis (AD) and to understand the underlying mechanisms involved. The AD model was established in C57 mice using calpolitol (a hypocalcemic analog of vitamin D3; MC903). Medication-free matrix ointment, CSZYRG, and mometasone furoate cream (positive control group) were applied to the injured areas. The skin lesions of AD model mice were photographed. Skin lesions were applied for the hematoxylin and eosin (H&E) staining to observe any pathological changes. Serum immunoglobulin IgE was detected by enzyme-linked immunosorbent assay (ELISA). The changes in the expression of inflammation-related factors TNF-α, IL-1β, and IL-6 in mice were detected using ELISA and qRT-PCR. Skin microflora samples were taken for 16S rDNA sequencing and analyzed for changes in the skin flora diversity, abundance, and dominant flora in mice. It was concluded that CSZYRG effectively alleviates skin lesions, serum IgE, and levels of TNF-α, IL-1β, and IL-6 in AD model mice. However, CSZYRG did not affect the skin microbial diversity of AD model mice but could exert an effect on the skin microbial community in AD mice and the relative abundance of the dominant microflora. CSZYRG may play a therapeutic role in AD by affecting the skin microbial community and relative abundance of dominant microflora in AD mice.

Preparation and Evaluation of Aloe-Vera and Vitamin E Anti-aging cream

Aging is a natural progressive process that leads to aesthetic and functional changes in the skin. Premature aging is also observed at young age around 20 due to pollution, cigarette smoke, sunlight, effects of an unhealthy lifestyle, insufficient nutritional intake, and prolonged illness. The aim of this research work is to formulate and evaluate an herbal antiaging face cream using Aloe-Vera and Vitamin E. Radical scavenging activity of prepared cream was studied using DPPH method and standard ascorbic acid was used. The evaluation test like, Organoleptic Test, pH, viscosity, spreadability, phase separation, homogeneity test, cream type, Draize test and ease to removal test were carried out. The stability study over three week was also executed.

Formulation and Evaluation of herbal ointment to treat psoriasis with Indigofera aspalathoides

Formulation and Evaluation of herbal ointment to treat psoriasis with Indigofera aspalathoides

Formulation and Evaluation of Topical Herbal Ointment from Euphorbia Royleana Latex Linn. for Psoriasis

Psoriasis is an inflammatory skin disease characterized by scaling ant inflammation (pain, swelling, heat and Redness) resulting in thick, redskin with silvery scales. These spots may be itchy or painful.Psoriasisis now treated with Systemic, local treatment and light therapy. These treatments have some negative and potentially fatal side effects. Patients With psoriasis are more likely to develop other diseases such as psoriatic arthritis, anxiety and depression, cancer, metabolic Syndrome, cardiovascular disease and Crohn’s disease. Most people use herbal medicine because it is readily available, Cheap and effective. Many plants have promising properties, including remarkable results in the treatment of psoriasis. The Aim of this study is to identify plants, herbal preparations and related therapies that could add value to the development of A better, safe and effective psoriasis drug which can help new researchers in the field (1).