Hepatic Bile Composition Research Articles

Influence of Cholestyramine, Bile Salt, and Cholesterol Feeding on the Lipid Composition of Hepatic Bile in Man

Influence of Cholestyramine, Bile Salt, and Cholesterol Feeding on the Lipid Composition of Hepatic Bile in Man

Effect of Secretin and Acetazolamide on the Volume and Electrolyte Composition of Hepatic Bile in Man

Rate of flow and electrolyte concentrations of human hepatic bile were determined in cholecystectomized subjects with T tubes in the common duct in the basal state and following secretin stimulation. Basal electrolyte composition of human hepatic bile resembled plasma values. Secretin augmented the rate of flow and stimulated the secretion of a bicarbonate rich fluid. The effect of secretin was partially inhibited by prior infusions of the carbonic anhydrase inhibitor, acetazolamide. The inhibitory effect was greater on output of bicarbonate than on output of fluid. It is concluded that secretin augments the flow of common duct bile in man with the addition of bicarbonate-containing fluid by a process which is catalyzed in part by carbonic anhydrase.

Bile acids and lipid metabolism. IV. Influence of bile acids on biliary and liver organelle phospholipids and cholesterol

ARTICLESBile acids and lipid metabolism. IV. Influence of bile acids on biliary and liver organelle phospholipids and cholesterolL Swell, C Entenman, GF Leong, and RJ HollowayL Swell, C Entenman, GF Leong, and RJ HollowayPublished Online:01 Dec 1968https://doi.org/10.1152/ajplegacy.1968.215.6.1390MoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByEffect of ursocholic acid on bile lipid secretion and compositionGastroenterology, Vol. 90, No. 4Effect of ML-236b (compactin) on biliary excretion of bile salts and lipids, and on bile flow, in the ratBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol. 794, No. 3Increased biliary cholesterol secretion in alloxan diabetic miceThe Japanese Journal of Surgery, Vol. 14, No. 2Cholesterol content as a possible determinant in the removal of chylomicron triglyceride by the liverAtherosclerosis, Vol. 47, No. 2Bile acid secretion by cultured rat hepatocytes. Regulation by cholesterol availability.Journal of Biological Chemistry, Vol. 258, No. 6The Enterohepatic CirculationBile acid metabolism in cirrhosisGastroenterology, Vol. 77, No. 6Recent Advances in the Synthesis, Metabolism and Secretion of Biliary PhospholipidsMechanisms of Solute Secretion into BilePathophysiology of the enterohepatic circulation of bile acids21 June 2005Biliary excretion of diethylstilbestrol in the rhesus monkey17 July 2015 | Journal of Pharmacokinetics and Biopharmaceutics, Vol. 6, No. 4Fatty Acid Composition of Glycerolipids of Animal TissuesMechanism of secretion of biliary lipids: Role of a microtubular system in hepatocellular transport of biliary lipids in the ratGastroenterology, Vol. 74, No. 1Methodology for the determination of bioavailability of labeled residues20 October 2009 | Journal of Toxicology and Environmental Health, Vol. 2, No. 4Activity of phospholipid-synthesizing enzymes in rat liver plasma membranes and the source of biliary lecithinLipids, Vol. 12, No. 2Biliary Lecithin Secretion. II. Effects of Dietary Choline and Biliary Lecithin SynthesisGastroenterology, Vol. 70, No. 3Influence of Bile Acids upon Biliary Cholesterol and Phospholipid Secretion in the DogEuropean Journal of Clinical Investigation, Vol. 6, No. 1Bile Phospholipids : Origin and FunctionCholeresis and hepatic transport mechanismsNaunyn-Schmiedeberg's Archives of Pharmacology, Vol. 290, No. 4Current Concepts of the Pathogenesis of Cholesterol GallstonesMedical Clinics of North America, Vol. 58, No. 6The present position concerning gallstone dissolution.Gut, Vol. 15, No. 11Gallefluß und Gallensäurenausscheidung bei fettreich ernährten Ratten in Abhängigkeit vom Fettsäurenmuster der Nahrung und von zusätzlich applizierter Cholsäure1 September 1974 | Zeitschrift für Ernährungswissenschaft, Vol. 13, No. 3Use of hybrid computers to analyze behavior of detailed models of biological systems—II: System parameters used in bile salt stimulated biliary cholesterol excretionComputers in Biology and Medicine, Vol. 4, No. 1Pathogenesis of GallstonesSurgical Clinics of North America, Vol. 53, No. 5The Biochemistry of Gallstone FormationClinics in Gastroenterology, Vol. 2, No. 1Alterations in Hepatic Bile Composition After CholecystectomyGastroenterology, Vol. 63, No. 3The Use of Rhesus Monkeys to Study Biliary Secretion with an Intact Enterohepatic Circulation25 March 2008 | Australian and New Zealand Journal of Medicine, Vol. 2, No. 1Synthesis of Phospholipids and Triglycerides in Human Liver Slices III. Influence of Bile Acids, Choline, and Linoleic Acid8 July 2009 | Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 29, No. 1Relationship of Bile Acid Pool Size to Biliary Lipid Excretion and the Formation of Litho Genic Bile in ManGastroenterology, Vol. 61, No. 5Relationship between the Biliary Excretion of Bile Acids and the Excretion of Water, Lecithin, and Cholesterol in Man20 March 2008 | European Journal of Clinical Investigation, Vol. 1, No. 4Kinetics and Pool Size of Primary Bile Acids in ManGastroenterology, Vol. 61, No. 1Bile Acid Metabolism in Patients with CirrhosisGastroenterology, Vol. 60, No. 4Release of lipoprotein cholesterol esters by the isolated perfused rat liverBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol. 231, No. 2The pathways of lecithin biosynthesis in essential fatty acid deficiency in hamstersBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol. 218, No. 1Metabolism and biliary excretion of the lipophilic drug molecules, imipramine and desmethylimipramine in the rat—IIBiochemical Pharmacology, Vol. 19, No. 8Diminished Bile Acid Pool Size in Patients with GallstonesGastroenterology, Vol. 59, No. 2Significance of the Liver in the Production of Lithogenic Bile in ManGastroenterology, Vol. 59, No. 1Regulation of Cholesterol MetabolismNew England Journal of Medicine, Vol. 282, No. 22Pathophysiology of cholestasisHuman Pathology, Vol. 1, No. 1 More from this issue > Volume 215Issue 6December 1968Pages 1390-1396 Copyright & PermissionsCopyright © 1968 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1968.215.6.1390PubMed5722999History Published online 1 December 1968 Published in print 1 December 1968 Metrics

Effects of acetazolamide and acid-base changes on biliary and pancreatic secretion.

ARTICLESEffects of acetazolamide and acid-base changes on biliary and pancreatic secretionBH Pak, SS Hong, HK Pak, and SK HongBH Pak, SS Hong, HK Pak, and SK HongPublished Online:01 Mar 1966https://doi.org/10.1152/ajplegacy.1966.210.3.624MoreSectionsPDF (921 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByHepatobiliary acid-base homeostasis: Insights from analogous secretory epitheliaJournal of Hepatology, Vol. 74, No. 2Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3− SecretionMin Goo Lee, Ehud Ohana, Hyun Woo Park, Dongki Yang, and Shmuel Muallem1 January 2012 | Physiological Reviews, Vol. 92, No. 1Cell Physiology of Pancreatic DuctsMECHANISMS OF BICARBONATE SECRETION IN THE PANCREATIC DUCTAnnual Review of Physiology, Vol. 67, No. 1Expression and distribution of the Na+-HCO3− cotransporter in human pancreasChristopher R. Marino, Virginia Jeanes, Walter F. Boron, and Bernhard M. Schmitt1 August 1999 | American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 277, No. 2INHIBITORY EFFECT OF OUABAIN AND ACETAZOLAMIDE ON SECRETIN-STIMULATED PANCREATIC EXOCRINE SECRETION IN ANAESTHETIZED DOGClinical and Experimental Pharmacology and Physiology, Vol. 16, No. 3Effects of Inhibition of Angiotensin Converting Enzyme and Carbonic Anhydrase on Fluid Production by Ciliary Process, Choroid Plexus, and PancreasJournal of Ocular Pharmacology and Therapeutics, Vol. 5, No. 4Importance of carbonic anhydrase for canalicular and ductular choleresis in the pigActa Physiologica Scandinavica, Vol. 133, No. 4DCCD ( N, N ′-Dicyclohexylcarbodiimide) Inhibits Biliary Secretion of HCO 38 July 2009 | Scandinavian Journal of Gastroenterology, Vol. 22, No. 2Mechanism of hepatic bicarbonate secretion and bile acid independent bile secretionEuropean Journal of Clinical Investigation, Vol. 13, No. 3Abolished relationship between pancreatic HCO -3 secretion and arterial pH during carbonic anhydrase inhibitionActa Physiologica Scandinavica, Vol. 114, No. 1Pancreatic basal secretion in alcohol-fed and normal dogsDigestive Diseases and Sciences, Vol. 26, No. 9Relationship between plasma pH and pancreatic HCO 3- secretion at different intravenous secretin infusion ratesActa Physiologica Scandinavica, Vol. 109, No. 2Die Besonderheiten des N-Stoffwechsels und die Produktivität der Tiere in Abhängigkeit von der Konzentration des HCO 3- , und CO 2 in den Geweben25 September 2009 | Archiv für Tierernaehrung, Vol. 30, No. 1-3Respiratory exchanges and acid-base balance during perfusion ofex vivo isolated pancreasThe American Journal of Digestive Diseases, Vol. 21, No. 5The secretion of electrolytes by the pancreasThe American Journal of Clinical Nutrition, Vol. 26, No. 3Bile SecretionClinics in Gastroenterology, Vol. 2, No. 1Lipid soluble weak organic acid buffers as ?substrate? for pancreatic secretionPfl�gers Archiv European Journal of Physiology, Vol. 323, No. 2Influence of bicarbonate-CO2- and glycodiazine buffer on the secretion of the isolated cat's pancreasPfl�gers Archiv European Journal of Physiology, Vol. 329, No. 4An Assessment of Models for Pancreatic SecretionGastroenterology, Vol. 59, No. 6Effect of Secretin and Acetazolamide on the Volume and Electrolyte Composition of Hepatic Bile in ManGastroenterology, Vol. 56, No. 2The additive effect of acetazolamide and ouabain on pancreatic secretion in vitroPfl�gers Archiv European Journal of Physiology, Vol. 311, No. 3The source of duodenal aspirate in man.Gut, Vol. 9, No. 4The Ins and Outs of Bicarbonate in the Alimentary TractGastroenterology, Vol. 54, No. 4Response to Secretin in ManGastroenterology, Vol. 54, No. 2 More from this issue > Volume 210Issue 3March 1966Pages 624-628 Copyright & PermissionsCopyright © 1966 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1966.210.3.624PubMed5933216History Published online 1 March 1966 Published in print 1 March 1966 Metrics

Control of bile flow in the cholecystectomized dog.

Rate of flow and composition of bile were measured in three unanesthetized, cholecystectomized dogs. One of these animals and one other dog were also studied after bilateral vagotomy. Bile flow and output of solids were increased by intravenous insulin and feeding. Tolbutamide had a similar choleretic effect. The anticholinergic drug, pipenzolate methylbromide blocked the choleretic effect of insulin. After bilateral vagotomy, the choleretic effect of both feeding and insulin-hypoglycemia was lost. Commercial pancreozymin had a choleretic action which may indicate a role of intestinal hormones in the response to feeding. Intraduodenal injection of hydrochloric acid was followed by an increase in only the volume of bile. Glucagon produced a hydrochloresis and an increase in bilirubin output. The results suggest that normal bile production in the dog after eating may be controlled in part by a mechanism involving the vagus nerves. The data also show that the insulin-hypoglycemia-induced choleresis differs from that of secretin. The composition of hepatic bile obtained from the common duct is consistent with an absorptive function of the ductal epithelium in the dog without a gallbladder.

Electrolyte excretion in bile.

The high concentration of certain test substances in both urine and bile suggests that similarities exist between the biliary and renal tubular functions. Evidence from dogs with permanent duodenal fistulas indicates that the rate of elaboration of bile depends primarily on the rate of secretion of bile salts. The variations in flow and composition of hepatic bile seem to result from the addition of a fluid which is similar in some respects to pancreatic juice.