Abstract
Rate of flow and electrolyte concentrations of human hepatic bile were determined in cholecystectomized subjects with T tubes in the common duct in the basal state and following secretin stimulation. Basal electrolyte composition of human hepatic bile resembled plasma values. Secretin augmented the rate of flow and stimulated the secretion of a bicarbonate rich fluid. The effect of secretin was partially inhibited by prior infusions of the carbonic anhydrase inhibitor, acetazolamide. The inhibitory effect was greater on output of bicarbonate than on output of fluid. It is concluded that secretin augments the flow of common duct bile in man with the addition of bicarbonate-containing fluid by a process which is catalyzed in part by carbonic anhydrase.
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