Recently, personalized air curtains combined with safety helmets have shown great potential in reducing particle inhalation exposure of workers in industrial settings. In this study, the helmet of the basic air curtain (BA) was optimized. One optimization method was to add a mask to the helmet of the basic air curtain (BAF), and the other optimization method was to add a face shield and sealing cloth to the helmet of the basic air curtain (BAFS). Computational fluid dynamics (CFD) method was used to compare the protective effect (PE) of the air curtain helmets with BA, BAF, and BAFS configurations. The impacts of the air supply velocity (0.05, 0.1, 0.2, 0.3, 0.4, and 0.5 m/s) of the air curtain in a static wind environment, and the direction and speed of the indoor airflow (0.1, 0.3, 0.5, 0.7 and 1 m/s) on the PE of the helmets were also investigated. Results showed that the BAFS helmet had the best respiratory protection, followed by the BAF and the BA helmet, regardless of indoor airflow conditions. The directional diversion effect of the face shield and the bidirectional blocking effect of the sealing cloth strengthened the PE. In the static indoor airflow environment, air supply velocity and helmet configurations had a remarkable impact on the PE. With the increase of the air supply velocity, the PE of the BA and optimized helmets showed S-shape and C-shape trends. When the air supply velocity reached 0.5 m/s, the PE of the BA, BAF, and BAFS helmets were close to 0.844, 0.985, and 1, respectively. In the uniform indoor airflow environments, the PE of the BAFS helmet was close to 1 and was almost undisturbed by the indoor airflow. This work may help inspire the development of respiratory protective equipment to reduce particulate exposure in industrial settings.