A RAMI (Reliability, Availability, Maintainability and Inspectability) assessment performed on the ITER Test Blanket Module (TBM) ancillary systems is presented. The assessment is aimed at evaluating design that may jeopardize the achievement of the overall 75% availability requirements for the TBM plant breakdown structure. The ancillary systems of the European Test Blanket Modules to be operated in ITER that have been analyzed in this assessment are the helium cooling systems (HCSs) of both the Helium Cooled Lithium Lead (HCLL) and Helium Cooled Pebble Bed (HCPB), the lithium-lead loop of the HCLL TBM and the Tritium Extraction System (TES) of the HCPB TBM. RAMI performance was assessed by means of reliability block diagrams (RBDs) over a foreseen mission of 20 years, with operating cycles reflecting ITER schedule. In particular, a set of events leading to unavailability of the systems was initially defined by means of a failure mode and effect analysis. Then RBDs were implemented according to reliability-wise integration of the components included in such systems. Different RBDs were defined depending on the component being judged to impact normal operation or start-up operation mode. Systems analysis was performed exploiting a modular approach in order to elicit the relative contribution to overall availability so to support possible design improvement by highlighting critical sub-systems. In particular the unavailability of cooling, tritium extraction and trapping functions were assessed separately for HCLL and HCPB concepts. Finally the integrated impact of all ancillary systems on overall tokamak operational availability was estimated and the assessed systems, considering the current preliminary level of design development, appear able to meet the expected performance.