A general overview on the role of heavy quarks as probes of the medium formed in high energy nuclear collisions is presented. Experimental data compared to model calculations at low and moderate pT are exploited to extract information on the transport coefficients of the medium, on possible modifications of heavy flavor hadronization in a hot environment and to provide quantitative answers to the issue of kinetic (and chemical, at conceivable future experimental facilities) thermalization of charm. Finally, the role of heavy flavor at high pT as a tool to study the mass and color-charge dependence the jet quenching is also analyzed.
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