Heavy Use Research Articles

A Study To Assess The Level Of Anxiety, Coping Strategies And Financial Burden Among The Spouses Of Alcoholics Attending De-Addiction Centre At Selected Hospital In Kolkata, West Bengal

Background: Alcoholism is one of the significant problems in India. It is a chronic progressive and often fatal disease but it has not a symptom like other diseases or emotional problems. Prolonged heavy use of alcohol is the cause of addiction. For this addiction higher anxiety level, depression, low self-esteem and communication apprehension have been reported in spouses of alcoholics and attributed to intense, stress and traumas experiences. [1] The World Health Organization (WHO) estimates (9th May 2022) that there are about Worldwide, 3 million deaths every year result from harmful use of alcohol. This represents 5.3% of all deaths. The excessive use of alcohol is one of the main causes of more than 200 disease and injury conditions. Overall, 5.1% of the global burden of disease and injury is attributable to alcohol, as measured in disability-adjusted life years (DALYs). A cause of death and disability relatively early in life is alcohol consumption. In people aged 20–39 years, approximately 13.5% of total deaths are attributable to alcohol. [9] Materials and Methods: A descriptive survey research design was adopted in this study. Non-probability Convenience sampling technique was used to select 100 spouses of alcoholics attending de-addiction centre of R. G. Kar M. C. H. Kolkata and de-addiction centre of N. R. S. M. C. H., Kolkata. Result: The findings revealed that majority of the subject 70% experiencing moderate level of anxiety, majority of the subject 76% adapted moderate coping strategies and majority of the subject 87% experiencing moderate financial burden. There was no relation between the level of anxiety and coping strategies among the spouses of alcoholics. There was a statistical significant association between anxiety with the selected socio demographic variables as educational qualification (χ2= 4.842 df =1, p>0.05), duration of marriage (χ2=4.762, df=1, p>0.05). Conclusion: Alcoholism had the negative effects towards the individual, family and also the nations. Lower education, loss of job, unemployment, unsocial behaves were also the effect of alcoholism. Awareness about the adverse effect of alcohol can prevent the alcoholism, thus reduce the level of anxiety of the spouses

UGT201H1 overexpression confers cyflumetofen resistance in Tetranychus cinnabarinus (Boisduval).

Tetranychus cinnabarinus is one of the most common polyphagous arthropod herbivores, and is primarily controlled by the application of acaricides. The heavy use of acaricides has led to high levels of resistance to acaricides such as cyflumetofen, which poses a threat to global resistance management programs. Cyflumetofen resistance is caused by an increase in metabolic detoxification; however, the role of uridine diphosphate (UDP)-glycosyltransferase (UGT) genes in cyflumetofen resistance remains to be determined. Synergist 5-nitrouracil (5-Nul) significantly enhanced cyflumetofen toxicity in T. cinnabarinus, which indicated that UGTs are involved in the development of cyflumetofen resistance. Transcriptomic analysis and quantitative (q)PCR assays demonstrated that the UGT genes, especially UGT201H1, were highly expressed in the YN-CyR strain, compared to those of the YN-S strain. The RNA interference (RNAi)-mediated knockdown of UGT201H1 expression diminished the levels of cyflumetofen resistance in YN-CyR mites. The findings additionally revealed that the recombinant UGT201H1 protein plays a role in metabolizing cyflumetofen. Our results also suggested that the aromatic hydrocarbon receptor (AhR) probably regulates the overexpression of the UGT201H1 detoxification gene. UGT201H1 is involved in cyflumetofen resistance, and AhR may regulates the overexpression of UGT201H1. These findings provide deeper insights into the molecular mechanisms underlying UGT-mediated metabolic resistance to chemical insecticides. © 2024 Society of Chemical Industry.

Estimating the alcohol-related burden of child maltreatment among Māori in Aotearoa, New Zealand.

To assesses the alcohol-related burden of child maltreatment among Māori in Aotearoa New Zealand. We compared the risk of child maltreatment among Māori (0-17 years) exposed to parents with alcohol-related hospitalisation or mental health/addiction service use. We also conducted a sensitivity analysis to estimate the number of cases of maltreatment that could be attributed to alcohol among Māori. A cohort study of 16,617 Māori aged 0-17 and their parents from 2000 to 2017 was conducted using the Statistics New Zealand Integrated Data Infrastructure. A Bayesian piecewise exponential model estimated the risk of time to first child maltreatment event. This analysis used data from child protection, hospital, mortality and police records, and specifically focused on the risk associated with exposure to parents with an alcohol-attributable hospitalisation or mental health/addiction service use event. Potential confounders for both parents and Māori (0-17 years) were included. We calculated a population-attributable fraction to estimate the proportion of maltreatment cases that could be attributed to alcohol in 2017. Results showed a 65% increased risk for young Māori exposed to parents with heavy alcohol use. We estimated 17% of substantiated child maltreatment among Māori could be attributed to parental hazardous alcohol consumption. Severe or hazardous alcohol consumption among parents is a risk factor for child maltreatment among Māori. Māori alcohol consumption and harm are symptomatic of wider inequities related, among other things, to the ongoing effects of colonisation, as well as gaps in the regulation of alcohol sales.

Assessment of the epidemiological risk factors of diabetic and hypertensive patients amongst the adult population

Background: 93 lakh people in India are undergoing diabetes and hypertension medication. It is true that the most important modifiable risk factors for type 2 diabetes and hypertension today are poor diet, cigarette smoking, and insufficient exercise. NCD-related deaths worldwide will increase by 17% by 2025, costing $47 trillion in lost productivity between 2011 and 2030. Methods: 300 diabetics, hypertensive and diabetic with hypertensive patients were selected from 8 urban wards and 8 rural panchayats of Bhopal by multi-stage random sampling. A semi-structured, pretested and validated questionnaire derived from WHO-STEPS survey was used to collect data in terms of socio-demographic variables, behavioural risk factors measurement and physical measurements. Mean and standard deviations were calculated for quantitative data, frequency and proportions were calculated for qualitative data. Chi-square value was calculated and p value less than 0.05 was considered statistically significant. Results: The mean age was 46.55±2.17 years. DBP found to be 3% more than 39% of males have systolic BP ≥140 mm of Hg. 33.6% fall under obese-I category. Current tobacco smokers, current alcohol consumption, heavy alcohol use, salt intake >5 gm/day, BMI ≥30 (obese-II) was significantly associated with hypertension. Conclusions: The study’s findings indicate that the alarmingly high occurrence of risk factors for diabetes and hypertension among adults need immediate attention. This indicates the need for an extensive screening and awareness campaign to identify undetected cases in the community and to offer early treatment and continuous follow-up to prevent consequences.

Robot‐assisted crack detection on complex shaped components using constant‐speed scanning infrared thermography with laser line excitation

AbstractInfrared thermography (IRT) using a focused laser is effective for surface defect detection. Nevertheless, testing complex‐shaped components remains a challenging task. The state‐of‐the‐art focuses on testing a limited region of interest rather than the full sample. Thus, detection and location of surface defects has been less researched. Most attempts require a manual scan of the full sample, which makes it hard to reconstruct the full scanned surface. Here, we introduce a reliable workflow for crack detection and semi‐automated inspection of complex‐shaped components using IRT excited with a laser line. A 6‐axis robot arm is used for moving the sample in front of the setup. This approach has been tested on a section of a rail and a gear, both containing defects due to heavy use. Crack detection is based on the segmentation of thermograms obtained by Fourier transform of sorted temperatures. Moreover, texture mapping is used to visualize a reconstructed thermogram on the 3D model of the sample. Our approach illustrates a reliable process towards the digitalization of thermographic testing.

Residual and enduring effects of cannabis use on cognitive and psychomotor function: A study of adults during unrestricted cannabis use, short-term abstinence, and protracted abstinence.

The impact of cannabis on cognitive and psychomotor function is important to understand, given the role of the endocannabinoid system in these critical processes. The literature has shown robust acute negative effects of cannabis on cognition and psychomotor skills during intoxication, and to a lesser degree, persisting effects following short-term abstinence up to 4 weeks. However, whether these decrements resolve after long-term cessation of use remains unclear. We evaluated cognitive and psychomotor function in 31 adults with current cannabis use during unrestricted use (UNR) and after a 3-day abstinence (RES), 23 adults with former cannabis use (> 90 days abstinent; FU), and 58 nonusing controls (CON) using the cognition and motor batteries of the National Institutes of Health Toolbox. Linear mixed models showed no significant differences in cognitive and motor performance between UNR, RES, and FU groups. Group effects emerged such that CON outperformed UNR on the Oral Reading Recognition Test, and CON outperformed both UNR and RES on the Picture Vocabulary Test. In terms of psychomotor function, FU, RES, and UNR performed better than CON on the Grip Strength Test. In this comprehensive examination of cognitive and psychomotor performance in adults with cannabis use with 3 days to > 90 days of abstinence, our results indicated that the cognitive impacts of chronic, heavy cannabis use are observable during short-term abstinence but remit after > 90 days of abstinence. This highlights widespread impacts of cannabis use abstinence across cognitive and psychomotor domains. Future studies are needed to evaluate whether these effects are also observable with use reduction, as opposed to abstinence. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Alcohol Protective Behavioral Strategy use and Negative Consequences Across Heavy Alcohol Users and Risky Drinkers.

This study investigated differences in alcohol protective behavioral strategy (PBSA) use and negative consequences (ARNC) experienced among heavy alcohol users and non-heavy alcohol users, and risky and non-risky drinkers. Participants were from 12 universities in the United States (n = 2,163 college students, Mage = 19.47), predominantly identified as White (74%), and female (68.7%), who completed measures of typical weekly drinking, risky drinking, ARNC, and PBSA use. ANOVAs revealed that the heavy alcohol users and risky drinkers reported significantly fewer total PBSA, subtype strategy use, and greater negative consequences than their counterparts. Harm reduction interventions may benefit from identifying and targeting college students who are engaging in heavy alcohol use and risky drinking regardless of sex.

Associations of demographic, health, and risk-taking behaviors with tattooing in a population-based cross-sectional study of ~18,000 US adults.

Little is known about current characteristics of individuals with tattoos. We quantified the prevalence of tattooing and associations of demographic, health, and risk-behavior factors with tattooing. We computed adjusted prevalence ratios (PR) of tattooing in a population-based analysis of > 18,000 Utah adults from the 2020-2021 Behavioral Risk Factor Surveillance System survey. The prevalence of tattooing was 26% among women and 22% among men, with the highest prevalence among women ages 25-29 (45%). Tattoo prevalence was higher among younger individuals, individuals with a lower education level, and those without religious affiliation. Tattoo prevalence was higher among indviduals with current tobacco (women: PR = 2.89 [95% confidence interval (CI): 2.60, 3.20]; men: 3.39 [2.98, 3.86]), e-cigarette (women: 2.44 [2.21, 2.69]; men: 2.64 [2.37, 2.94]), and heavy alcohol use (women: 2.16 [1.93, 2.43]; men: 1.89 [1.63, 2.19]). Tattoo prevalence was lower among individuals receiving a flu (women: 0.84 [0.76, 0.92]; men: 0.75 [0.67, 0.84]) or COVID-19 vaccine (women: 0.65 [0.54, 0.79]; men: 0.75 [0.61, 0.92]). Several risk-taking behaviors were associated with tattooing. Tattoo studios/conventions may present opportunities for partnership with tobacco cessation, alcohol reduction, and vaccination public health initiatives.

Dexmedetomidine as Adjunctive Therapy for the Treatment of Alcohol Withdrawal Syndrome: A Systematic Review and Meta-Analysis.

Alcohol withdrawal syndrome (AWS) is defined as the cessation or reduction in heavy and prolonged alcohol use within several hours to a few days of cessation. The recommended first-line therapy for AWS ranging from mild to severe or complicated remains benzodiazepines; in cases where benzodiazepines are not adequate in controlling persistent autonomic hyperactivity or anxiety, dexmedetomidine could be utilized. The possible advantage of dexmedetomidine compared to benzodiazepines is that it does not cause respiratory depression, thus reducing the risk of intubation and hospitalization in the ICUs, with the potential reduction in healthcare costs. The purpose of this systematic review and meta-analysis (PROSPERO CRD42018084370) is to evaluate the effectiveness and safety of dexmedetomidine as adjunctive therapy to the standard of care for the treatment of AWS. We retrieved literature from PubMed, EMBASE, and CENTRAL until 10 January 2024. Eligible studies were both randomized trials and nonrandomised studies with a control group, published in the English language and peer-reviewed journals. The primary outcome was tracheal intubation; secondary outcomes were (i) bradycardia and (ii) hypotension. A total of 3585 papers were retrieved: 2635 from EMBASE, 930 from Medline, and 20 from CENTRAL. After eliminating duplicates, 2960 papers were screened by title and abstract; 75 out of the 2960 papers were read in full text. The qualitative synthesis included nine of all manuscripts read in full text. The quantitative synthesis included eight studies for the primary outcome (tracheal intubation), seven for the secondary outcome bradycardia, and six for the secondary outcome hypotension. The meta-analysis showed that Dexmedetomidine, as adjunctive therapy, is not more effective than standard therapy in reducing the risk of tracheal intubation in AWS [RR: 0.57, 95% CI: 0.25-1.3, p = 0.15]. It also appears to be less safe than sedative therapy as it significantly increases the risk of bradycardia [RR: 2.68, 95% CI: 1.79-4.16, p = 0.0016]. Hypotension was not significantly different in patients who received dexmedetomidine [RR: 1.5, 95% CI: 0.69-3.49, p = 0.21].

Effectiveness and biochemical impact of ozone gas and silica nanoparticles on Culex pipiens (Diptera: Culicidae)

Culex pipiens (Diptera: Culicidae) is a vector of many serious human diseases, and its control by the heavy use of chemical insecticides has led to the evolution of insecticide resistance and high environmental risks. Many safe alternatives, such as ozone gas (O3) and silica nanoparticles (silica NPs) can reduce these risks. Therefore, O3 and silica NPs were applied to 3rd larval instars of Cx. pipiens at different concentrations (100, 200, and 400 ppm) for different exposure times (1, 2, 3, and 5 min for O3 and 24, 48, and 72 h for silica NPs). The activity of some vital antioxidant enzymes as well as scanning electron microscopy of the body surface were also investigated. A positive correlation was observed between larval mortality % and the tested concentrations of O3 and silica NPs. O3 was more effective than silica NPs, it resulted in 92% mortality at 400 ppm for a short exposure time (5 min). O3-exposed larvae exhibited a significant increase in glutathione peroxidase, glutathione S-transferase, and catalase activities as well as the total antioxidant capacity. Scanning electron microscopy showing disruptive effects on the body surface morphology of ozone and silica NPs treated larvae. These results provide evidence that O3 and silica NPs have the potential for use as alternative vector control tools against Cx. pipiens.

A Population-Based Study on Women Who Used Alcohol during Pregnancy and Their Neonates in Ontario, Canada.

Data from birth registries can be studied to assess the prevalence of prenatal alcohol use and associated maternal and neonatal outcomes. Linked maternal and neonatal data (2015-2018) for alcohol-exposed pregnancies were obtained from the Better Outcomes Registry and Network (BORN) Ontario. Descriptive statistics were generated for maternal demographics, prenatal substance use, mental health/substance use history, and neonatal outcomes. Logistic regression models were performed to assess the odds of prenatal heavy (binge or weekly) alcohol and other substance use based on mental health/substance use history and other maternal demographics, and the impacts of heavy alcohol use and other prenatal substance exposures on neonatal outcomes. A total of 10,172 (2.4%) women reported alcohol use during pregnancy. One-third had pre-existing or current mental health and/or substance use problems, which was associated with significantly higher odds of heavy alcohol use during pregnancy. Prenatal exposure to heavy alcohol use was associated with increased odds of neonatal abstinence syndrome (2.5 times); respiratory distress syndrome (2.3 times); neonatal intensive care unit (NICU) admission (58%); and hyperbilirubinemia (57%). Prenatal exposure to one or more substances in addition to alcohol was associated with significantly higher odds of fetal/maternal/placental pregnancy complications; preterm birth; NICU admission; low APGAR scores; one or more confirmed congenital anomalies at birth; respiratory distress syndrome; and intrauterine growth restriction. It is crucial to routinely screen childbearing-age and pregnant women for alcohol and other substance use as well as mental health problems in order to prevent adverse maternal and neonatal outcomes.

Microorganism-Driven 2,4-D Biodegradation: Current Status and Emerging Opportunities.

The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) has been widely used around the world in both agricultural and non-agricultural fields due to its high activity. However, the heavy use of 2,4-D has resulted in serious environmental contamination, posing a significant risk to non-target organisms, including human beings. This has raised substantial concerns regarding its impact. In addition to agricultural use, accidental spills of 2,4-D can pose serious threats to human health and the ecosystem, emphasizing the importance of prompt pollution remediation. A variety of technologies have been developed to remove 2,4-D residues from the environment, such as incineration, adsorption, ozonation, photodegradation, the photo-Fenton process, and microbial degradation. Compared with traditional physical and chemical remediation methods, microorganisms are the most effective way to remediate 2,4-D pollution because of their rich species, wide distribution, and diverse metabolic pathways. Numerous studies demonstrate that the degradation of 2,4-D in the environment is primarily driven by enzymatic processes carried out by soil microorganisms. To date, a number of bacterial and fungal strains associated with 2,4-D biodegradation have been isolated, such as Sphingomonas, Pseudomonas, Cupriavidus, Achromobacter, Ochrobactrum, Mortierella, and Umbelopsis. Moreover, several key enzymes and genes responsible for 2,4-D biodegradation are also being identified. However, further in-depth research based on multi-omics is needed to elaborate their role in the evolution of novel catabolic pathways and the microbial degradation of 2,4-D. Here, this review provides a comprehensive analysis of recent progress on elucidating the degradation mechanisms of the herbicide 2,4-D, including the microbial strains responsible for its degradation, the enzymes participating in its degradation, and the associated genetic components. Furthermore, it explores the complex biochemical pathways and molecular mechanisms involved in the biodegradation of 2,4-D. In addition, molecular docking techniques are employed to identify crucial amino acids within an alpha-ketoglutarate-dependent 2,4-D dioxygenase that interacts with 2,4-D, thereby offering valuable insights that can inform the development of effective strategies for the biological remediation of this herbicide.

Isolation and identification of entomopathogenic fungi strains for Colorado potato beetle (Leptinotarsa decemlineata) control.

The Colorado potato beetle, Leptinotarsa decemlineata (Say) (Coleoptera: Chrysomelidae) is the most widespread insect pest that causes major economic losses, especially on potatoes. Due to heavy insecticide use, this species now resists most pesticides, posing a significant control challenge. Frequent pesticide application also harms non-target organisms, the environment, and human health. Hence, utilizing biocontrol agents like entomopathogenic fungi (EPF) offers a viable alternative for pest management. The aim of this study was to identify and characterize new EPF strains isolated from soil samples and evaluate their efficacy against adult L. decemlineata under laboratory conditions. Soil samples were collected in potato fields or uncultivated areas adjacent to the field in the Czech Republic and the EPF strains were isolated using a modified Tenebrio bait method. A total of 20 fungal strains were isolated and identified using morphological and molecular markers based on the 28S rRNA, ITS, and elongation factor 1-alpha gene sequences as Beauveria bassiana (Bals.-Criv.) Vuill., Beauveria brongniartii (Sacc.) Petch, and Cordyceps fumosorosea (Wize) Kepler, B. Shrestha & Spatafora (Hypocreales: Cordycipitaceae), Purpureocillium lilacinum (Thom.) Luangsa-ard, Houbraken, Hywel-Jones & Samson (Hypocreales: Ophiocordycipitaceae), Metarhizium brunneum (Petch), and Metarhizium robertsii Bisch., Rehner & Humber (Hypocreales: Clavicipitaceae). The bioassays revealed high variability among virulence of these strains against L. decemlineata with the shortest median time to death (LT50=5 days) in M. robertsii strain MAN3b. Results shown that some EPF strains, particularly those of genera Metarhizium, can be promising biocontrol agents against the Colorado potato beetle.

Within-person and between-person associations of access to environmental reward with alcohol and cannabis use and consequences among young adults

BackgroundRecent behavioural economic models of substance use suggest that low access to environmental reward may increase risk for heavy substance use and associated harms. Most prior studies of these associations have been cross-sectional and have focused on alcohol. The current study extends this research using longitudinal data to examine the within-person and between-person associations of environmental reward access with both alcohol and cannabis outcomes. MethodYoung adults (N = 119, 64.71 % female) completed an online survey at three time points, spaced six months apart. The survey included measures of alcohol and cannabis use and consequences, and two facets of environmental reward access: reward probability (i.e., likelihood of experiencing environmental reward) and environmental suppression (i.e., diminished availability of environmental reward). ResultsMultilevel models revealed that at the between-person level (i.e., averaged across time points), greater environmental suppression (but not reward probability) was significantly associated with more frequent cannabis use, and greater reward probability (but not environmental suppression) was significantly associated with heavier alcohol use. Higher environmental suppression (but not reward probability) was also associated with greater alcohol and cannabis consequences at the between-person level, over and above level of use. A significant within-person association also was observed, wherein participants reported relative increases in cannabis consequences during time periods when they also reported relative decreases in the availability of environmental reward. ConclusionsResults highlight environmental suppression as a risk factor for more frequent cannabis use and for both alcohol and cannabis consequences, and provide novel support for a within-person association between environmental suppression and cannabis consequences over time. Findings may inform contextual interventions for young adult substance use.

Conformity to masculine norms and its association with drinking behaviors and alcohol-related consequences among adult men: A meta-analysis

ObjectivesStudies typically show that men are at higher risk for heavy alcohol use than women. Research linking conformity to masculine norms and drinking behaviors among adult males has grown steadily during the past 10 years. We conducted the first meta-analysis that examines (a) the strength of the associations between conformity to masculine norms and alcohol use outcomes, and (b) the extent to which the strength of these associations would be affected by the specific type of drinking behavior or methodological factors. MethodsWe included 35 studies (N=32,412) in this meta-analysis that examined the association between scores on the Conformity to Masculine Norms Inventory (CMNI) and alcohol use outcomes. ResultsAcross all studies, the average correlation between conformity to masculine norms and alcohol variables was small (r = 0.17). The associations between conformity to masculine norms and specific alcohol variables were also modest: alcohol use composite score of frequency and quantity (r = 0.20), binge drinking frequency (r = 0.14), and alcohol-related consequences (r = 0.16). The mean correlation between each CMNI subscale and alcohol variables was also small (alcohol use composite, rs range from 0.07 to 0.22; alcohol-related consequences, rs range from 0.04 to 0.29; frequency of binge drinking, rs range from −0.06 to 0.22). There was a significant difference in effect size by specific type of drinking behavior (i.e., effect sizes for binge drinking were smaller than effect sizes for other alcohol variables). Methodological factors (i.e., CMNI version; sample type: university vs. adult vs. mixed samples; country where the study was conducted) did not affect the associations between masculine norms and the alcohol-outcome variables. ConclusionsConformity to masculine norms is modestly associated with drinking behaviors and alcohol-related consequences. The effect sizes reported in this meta-analysis can assist in power analyses in future studies on conformity to masculine norms and specific drinking behaviors among adult males.

Recent development of chitosan-based biomaterials for treatment of osteomyelitis

Abstract Osteomyelitis is a complex infectious disease caused by bacterial infection, which has always been a difficult problem for clinical orthopedic surgeons. Although the traditional methods are effective in treating osteomyelitis, the heavy use of antibiotics and surgical treatment cause serious side effects and lead to bone loss and healing difficulties after surgery. Chitosan (CS), a natural polymer material, is a deacetylated derivative of chitin, which has good biodegradability, antibacterial, and osteogenic properties, and has been widely used in the treatment of osteomyelitis. In this review, the recent research progress in the application of CS based composites such as micro-nano drug delivery carriers, hydrogels, coating materials, and bone tissue engineering scaffolds for the treatment of osteomyelitis is summarized, in order to provide certain experimental and theoretical support for the development of CS based composites.

Daily cannabis use and cognitive impairment in community residents aged 50 and over

ABSTRACT Background Cannabis use is associated with cognitive dysfunction in younger adults, but little is known about its role as a risk factor for dementia. This study aimed to explore the association between daily cannabis use and cognitive impairment in a cohort study of middle-aged and older people at risk of dementia. Methods Sample drawn from a cross-sectional study involving 15,582 people aged 50 and over from PROTECT study. Lifetime heavy cannabis use was defined by daily use. Results A total of 4203 (27%) participants reported lifetime cannabis use, of whom 4097 responses to frequency of use were obtained. Among them, 259 participants reported lifetime daily, and 3838 reported less than daily use. Those with lifetime daily cannabis use were more likely than those without to be unmarried, of lower educational attainment, and current or past tobacco smokers. They were more likely to show moderate or moderate-to-severe anxiety and depression. Baseline lifetime daily cannabis use was also associated with improved verbal reasoning but not with change in other cognitive scores. Conclusions Given improved verbal reasoning in people with daily lifetime cannabis use, the relationship between quantity and frequency of cannabis use and cognitive impairment in later life warrants further examination.

Severe odontogenic infections in patients with mental disorders—the challenge of ineffective initial treatment

ObjectivesThis study clarified possible delays and deficiencies in severe odontogenic infection (OI) treatment in patients with mental disorders. Study DesignData of hospitalized patients with severe OI were evaluated retrospectively. The outcome variable was preceding health care visits prior to hospitalization. The primary predictor was patient's mental disorder. Explanatory variables were age, sex, smoking, heavy alcohol use, immunocompromised disease or medication, and time span from beginning of symptoms to hospitalization. Also, factors leading to intensive care unit (ICU) care were evaluated. ResultsPreceding visits prior to hospitalization were found in 61 (35.5%) out of 172 patients with OI. In total, 27 patients (15.7%) had a current mental disorder, more commonly in women (26.0%) than in men (8.1%) (P=0.001). Patients with mental disorders had preceding health care visits related to the current infection notably more often than patients without recent psychiatric history (51.9% vs. 32.4%), P=0.053). Patient-related treatment delay remained non-significant. Heavy alcohol use (P=0.010) and smoking (P=0.025) predicted ICU treatment, but no association with patient's mental disorder was found. ConclusionsA patient's mental disorder can complicate diagnosis of OI. Effective and timely treatment requires the professional's ability to simultaneously identify the patient's mental health challenges and progressing OI.

Robust and repairable PET superwicking surfaces: A simple two-step fabrication approach for enhanced liquid transport

Superwicking surfaces stand out for their superior wicking abilities that expedite liquid flow across their structural form. The surface has attracted significant attention due to its promising applications in water harvesting, thermal management, biomedical fields, and more. However, minimizing manufacturing costs while ensuring long-term stability remains a challenge in the production of superwicking surfaces and enhancing their applications. This study presents the development of polyethylene terephthalate (PET) superwicking surfaces using a straightforward two-step technique with sandpaper abrasion and nanocomposite coating of TiO2-SiO2. Superwicking performance was evaluated through droplet spread analysis, contact angle measurements, and water drying tests. Results exhibited a more than 100% rise in absorbed water film thickness on the 180-grit abraded superwicking surface versus the coating on raw PET. Additionally, a 10μl droplet displayed more than triple the spreading diameter. Sandpaper abrasion, high-pressure water impact, and outdoor stability tests appraised surface durability. The PET superwicking surface showed enhanced mechanical durability and outdoor stability, attributed to protective microgrooves and photocatalytic self-cleaning capacity. The findings of this study clearly address the high cost, instability, and extreme lack of durability associated with conventional superwicking surface preparation. More importantly, the developed self-repairing capability of the surface allows it to be restored by reapplying the spray coating after the nanoparticles have been worn away due to heavy use. This advancement will significantly promote the use of such surfaces in heat transfer and self-cleaning applications.

Does biodiversity affect Olive fly populations? Evidence from different understorey treatments

The agricultural industry is intensifying production methods to increase crop yields. Olive cultivation, the prevalent permanent crop in Europe and the Mediterranean area, involves intense practices with heavy agrochemical use. This significantly impacts agroecosystem biodiversity and its ecosystem services. In this study, we explore how biodiversity influences the adult olive fly (Bactrocera oleae (Rossi)) population in Lesvos Island, Greece, under different understorey management practices in olive groves. Our findings show that increased plant and arthropod abundance and diversity negatively affect the olive fly. The results suggest that maintaining undisturbed plant cover enhances olive grove biodiversity, ecosystem services, and biological control of the olive fly. Moreover, this practice is in line with Integrated Pest Management principles and Conservation Biological Control approach.