A theoretical model for describing the heat transfer characteristics of a turbine-based combined cycle (TBCC) engine cabin was established in Matlab/Simulink to quickly predict the thermal protection performance for engine accessories. The model’s effectiveness was verified by comparing the numerical results with the experimental data. The effects of different heat insulation layer thicknesses and fuel temperatures on the thermal protection performance are discussed; based on these effects, the heat insulation layer of 5 mm and fuel of 353 K were chosen to design the thermal protection cases. Nineteen different thermal protection cases were proposed and evaluated by using the model. Two representative accessories were chosen for the evaluation of the thermal protection performance of these cases. For accessory 1 with an internal heat source of 1000 W and internal fuel access, the thermal protection effect of adding a heat insulation layer and ventilation was the best, which decreased the accessory temperature by 43 K. For accessory 2 without an internal heat source, the thermal protection effect of adding a heat insulation layer to the casing and fuel cooling was the most ideal, which decreased the accessory temperature by 190 K. In addition, a comprehensive assessment was made to compare the performances of thermal protection cases.