The article discusses the path of dynamic development, invention and use of common building materials and structural solutions in the architectural design and construction of buildings for medical purposes. The analysis has been carried out since the Middle Ages, continuing and covering the periods of Ukraine-Rus in the XIII-XVII centuries, New time, the newest period in the history of Ukraine. The positive and negative properties of the main natural and artificial building and finishing materials (wood, stone, adobe varieties, building ceramics, glass and other melt types, prefabricated reinforced concrete products, monolithic concrete) are identified and systematized, their role and influence on the development of potential are investigated medicinal properties of buildings, functionally designed to protect the health of the country's population. A number of proposals were provided on further directions for creating modern and progressive architectural solutions for various types of healthcare buildings in Ukraine with the integration and implementation of maximum safety from the use of structures, building and finishing materials, energy-efficient technologies, which together are aimed at the emergence of the latest projects taking into account a sustainable vector, typical for the development of the world architectural and urban planning practice.