Health Of Future Generations Research Articles

The impacts of income inequality, forest area, and technology innovations on ecological footprint in Indonesia: ARDL and ML approach

Reducing humans’ ecological footprint (ECF) is critical for guaranteeing a sustainable future and sustaining the planet's health for future generations. Consequently, sustainability policies and development aim to minimize ECF and guarantee a sustainable future. This study analyzes the effects of gross domestic product (GDP), financial development, renewable energy, share of global forest area, and technological innovations on the ECF of the Indonesian economy from 1990 to 2020. The Autoregressive Distributed Lag approach is applied to observe the varying levels of influence across variables. The findings show significant short-term links between GDP, income inequality, technological advancements, and ECF, and statistically significant long-term relationships between GDP, share of forest area, and technological innovation. The machine learning approach uses neural networks and regression as its parametric models to analyze the data for prediction. Both models can predict how the parameters interacted with ECF, with neural networks making more accurate predictions. The study reveals that economic growth intensifies ECF, whereas income equality decreases it. Technological advancements and forest expansion benefit the environment by reducing the footprint. These insights can provide policy recommendations to minimize ECF in Indonesia and strengthen the efforts to achieve a sustainable future.

Atulyagotreeya Vivaha: A scientific review and case series on non-consanguineous marriage

Atulya Gotra Vivaha (non-consanguineous marriages), emphasized in Ayurveda and supported by modern genetics, plays a crucial role in reducing the risk of congenital anomalies and genetic disorders. Ancient Ayurvedic texts, such as Acharya Charaka’s Atulyagotreeya Sharira Adhyaya, advocate marrying outside one's Gotra to prevent the inheritance of faulty genes and ensure healthier progeny. Modern science also confirms that consanguineous marriages increase the risk of autosomal recessive disorders like mental retardation and congenital anomalies. Despite these insights, cultural norms, ignorance, and lack of awareness drive individuals, especially in less-educated communities, to practice consanguineous marriages, risking the life and health of future generations. This review highlights the need for awareness and education regarding the risks of such unions. Promoting Atulya Gotra marriages can help reduce the burden of genetic disorders and protect every child's life, which is invaluable to the well-being of society.

Adverse Effects of Nicotine on Human Sperm Nuclear Proteins.

The effects of smoking on human health have long been documented. However, only a few studies have highlighted the direct effects of nicotine on sperm function. Nicotine, as a chemical compound found in tobacco, has been shown to modulate different aspects of spermatogenesis and sperm functions. Nicotine can lead to a reduction in the number of sperm, their motility and functionality. It can change the molecular expressions involved in sperm function, including genes encoding sperm nuclear proteins. The most important nuclear proteins that play a critical role in sperm function are known as H2B histone family, member W, testis-specific (H2BFWT), transition protein 1 (TNP1), transition protein 2 (TNP2), protamine-1 (PRM1), and protamine-2 (PRM2). These proteins are involved in sperm chromatin condensation, which in turn affects fertilization and embryonic development. Any alteration in the expression of these genes due to nicotine exposure/usage may lead to adverse implications in couples' fertility and the health of future generations. Since research in this area is still relatively new, it underscores the importance of understanding the potential side effects of environmental factors such as nicotine on reproductive health.

Assessing Moroccan physician knowledge and practices regarding maternal obesity's impact on childhood obesity: Implications for prevention and intervention.

Childhood obesity is a growing global concern with far-reaching health implications. This study focuses on evaluating the knowledge and practices of physicians in Morocco regarding the link between maternal obesity and childhood obesity. Despite the increasing prevalence of childhood obesity worldwide, this issue remains inadequately addressed in the Moroccan context. To assess the awareness and practices of physicians in Morocco concerning the connection between maternal obesity and childhood obesity. The research encompasses a comprehensive survey of practicing physicians, revealing significant gaps in awareness and practices related to maternal obesity. Notably, a significant portion of doctors do not provide adequate guidance to overweight pregnant women, highlighting the urgency for targeted educational programs. In conclusion, this research illuminates critical areas for improvement in tackling childhood obesity in Morocco. By addressing these gaps, fostering awareness, and enhancing medical practices, the healthcare system can contribute significantly to preventing childhood obesity and improving the overall health of future generations.

Unveiling new insights into China's marine ecosystem: Exploring the fishing grounds load capacity curve

As one of the most swiftly industrializing countries in the world, China is struggling with significant challenges facing its environment, in particular in its marine ecosystems. Hence, economic activities increasingly are influencing these ecosystems, requiring their study crucial for sustainable development. Therefore, it is paramount perceiving the potential implications of economic growth and foreign direct investment (FDI) for marine health. The study aims to explore the impact of economic growth and FDI on China's marine ecosystem during 1980–2019, examining the probable intersections of economic advancement, FDI, and marine sustainability, the study used a novel nonlinear Fourier Autoregressive Distributed Lags (FARDL) approach. Notably, the paper confirms the Fishing Grounds Load Capacity Curve (FGLCC) hypothesis, demonstrating a nonlinear affiliation among income levels and maritime conditions. Moreover, the results point out that FDI initially worsens marine conditions until a certain threshold is reached, marking a pivotal change in the influence of FDI from environmental degradation to improvement. In addition, the study underscores the critical need for policies that balance economic development with Chines' marine environmental sustainability, emphasizing the importance of intended regulatory and strategic interventions. These insights are vital for enhancing marine requirements and ensuring well-being and health of future generations, providing significant implications maritime policymakers in addressing marine environmental challenges amid economic development.

Targeted approach to assessing the impact of living conditions and social factors of the habitat on the medico-demographic status of rural territories in the Arctic zone of the Russian Federation

BACKGROUND:According to the Federal Law “On Sanitary-Epidemiological Well-being of the Population” the “environmental factors that have or may have an impact on humans and on health of future generations” along with chemical, physical and biological factors, also include “social factors". Within framework of section “State of Public Health in Connection with the State of Natural Environment and Living Conditions” of the system of state sanitary and epidemiological regulation, a significant number of normative and methodological documents have been approved aimed at assessing the impact of chemical, physical and biological environmental factors on population health, while not a single document has been developed concerning “social factors of habitat” or “living conditions”. In the “Strategy for the Development of the Arctic Zone of the Russian Federation (AZRF) until 2035” , the “main dangers, challenges and threats that form risks for development of AZRF” include clear signs of deterioration in medico-demographic situation, where, along with migration outflow, reduction of population number, high mortality rate, “lag behind all-Russian values of indicators characterizing quality of life”, poor state of social, housing, communal, transport infrastructure were noted.
 OBJECTIVES:development of the concept of “living conditions” as a set of “social factors of habitat” formed by “social infrastructure” of a settlement; development of conceptual model of determinants of human health, indicating place of living conditions (social infrastructure) in the frame of habitat; scientific substantiation of concept of “harmful effects of social factors of habitat”; development of targeted approach to assessing the impact of living conditions on medico-demographic status of rural areas of AZRF using scoring system for assessing living conditions, which makes it possible to rank individual villages according to the value of infrastructure indices and the integral index of living conditions (IILC).
 PRACTICAL SIGNIFICANCE:Implementation in practice of the proposed targeted methodological approach will make it possible to scientifically substantiate the need to take differentiated measures (managerial decisions) in relation to the identified “risk territorie”, “risk group”, and “risk pathologies”, aimed at improving living conditions, preserving public health, ensuring sanitary-epidemiological well-being, reducing the intensity of negative trends in demographic processes in the regions of AZRF.

The Magnitude and Related Risk Factors of Obesity and Overweight among Medical Students at Shendi University, Sudan

Background: Today, obesity is a serious health issue that is growing around the world. Almost 500 million adults worldwide were obese, and 1.5 billion were overweight, according to a World Health Organization (WHO) report. This number is estimated to increase in the years to come. Objective: To evaluate the prevalence of obesity and overweight among medical students at the Shendi University College of Medicine and its relationship to demographic parameters. Materials and Methods: A cross-sectional descriptive-analytic study was conducted on medical students of the faculty of medicine at Shendi University, and a sample of students was systematically randomly collected. Data was collected by using an open and closed questionnaire. Direct measurement of weight and height, then the calculation of BMI. Also, direct measurement of waist and hip, then the calculation of WHR. Results: 43% of the students were classified as average. 26% of people were overweight, and 21% were obese. In other words, the study discovered that women are more likely than men to be overweight or obese. According to the findings, those who live in urban areas gain weight noticeably more than people who live in rural areas. Regarding the behavioral aspect, there was a substantial relationship between those with a positive family history of obesity and those who are of normal weight, as well as a positive relationship between those who ate more than two meals each day. Conclusions: University students frequently engage in risky health behaviors, so it's important to educate them on how to prevent them, especially when it comes to topics like exercise and nutrition. For the sake of their health and the health of future generations, prospective healthcare professionals must adopt the proper eating habits and a healthy lifestyle. We advise modifying BMI to account for fat distribution and coexisting diseases to gain a thorough understanding of the current situation.

Food, nutrition, and fertility: from soil to fork

Food and nutrition-related factors, including foods and nutrients consumed, dietary patterns, use of dietary supplements, adiposity, and exposure to food-related environmental contaminants, have the potential to impact semen quality and male and female fertility; obstetric, fetal, and birth outcomes; and the health of future generations, but gaps in evidence remain. On 9 November 2022, Tufts University’s Friedman School of Nutrition Science and Policy and the school's Food and Nutrition Innovation Institute hosted a 1-d meeting to explore the evidence and evidence gaps regarding the relationships between food, nutrition, and fertility. Topics addressed included male fertility, female fertility and gestation, and intergenerational effects. This meeting report summarizes the presentations and deliberations from the meeting.Regarding male fertility, a positive association exists with a healthy dietary pattern, with high-quality evidence for semen quality and lower quality evidence for clinical outcomes. Folic acid and zinc supplementation have been found to not impact male fertility. In females, body weight status and other nutrition-related factors are linked to nearly half of all ovulation disorders, a leading cause of female infertility. Females with obesity have worse fertility treatment, pregnancy-related, and birth outcomes. Environmental contaminants found in food, water, or its packaging, including lead, perfluorinated alkyl substances, phthalates, and phenols, adversely impact female reproductive outcomes. Epigenetic research has found that maternal and paternal dietary-related factors can impact outcomes for future generations.Priority evidence gaps identified by meeting participants relate to the effects of nutrition and dietary patterns on fertility, gaps in communication regarding fertility optimization through changes in nutritional and environmental exposures, and interventions impacting germ cell mechanisms through dietary effects. Participants developed research proposals to address the priority evidence gaps. The workshop findings serve as a foundation for future prioritization of scientific research to address evidence gaps related to food, nutrition, and fertility.

Male obesity: Associated effects on fertility and the outcomes of offspring.

Obesity rates are increasing globally, making it imperative to comprehend the effects of parental obesity on human reproduction. This review aims to highlight the impact of male obesity on reproductive and offspring outcomes. Male obesity has been shown to affect fertility through various mechanisms, including changes in semen quality, difficulty with natural conception, and worsened assisted reproductive technology outcomes. The evidence regarding the impact of male obesity on success of sperm retrieval is conflicting, but all aforementioned adverse effects may be modifiable with weight loss. Moreover, paternal obesity may influence atypical offspring outcomes, such as placental abnormalities and disruptions in fetal development, which may be moderated by epigenetic pathways. Further research is needed to fully understand the complex relationships and underlying mechanisms involved. Gaining more insight into the impact of male obesity on fertility and offspring outcomes can aid in the development of targeted interventions to improve family planning and the health of future generations.

Neighbourhood active living environment and obesity in adolescents using the Millennium Cohort Study

ObjectivesYouth obesity has increased substantially in recent decades; however, the potential role of the built environment in mitigating these trends is unclear. This study examines whether more walkable neighbourhoods are associated with lower levels of overweight/obesity for adolescents compared to less walkable neighbourhoods, after considering the potential role of socio-economic and lifestyle characteristics.
 MethodsWe examine overweight/obesity levels for all singleton 14 years-old children living in Wales, using the UK Millennium Cohort Study. Children are classified as healthy weight, overweight and obese using international age and sex adjusted cut-offs for body mass index (BMI). The built environment is assessed using the active living environments (ALE) index for 2017-2018 classified into 5 categories (1-low walkability and 5 – high walkability). We apply regression analysis and adjust for children characteristics (e.g., physical activity), parental socio-economic circumstances and lifestyle choices (e.g., maternal education, physical activity).
 ResultsWe assess the hypothesis that the built environment is associated with adolescents’ overweight/obesity levels and examine how much of this association could be modified by parental socioeconomic circumstances and lifestyle choices. The ALE index is higher in urban compared to rural areas. To capture variations in Wales’ population, we are conducting a stratified analysis to explore any differences on the association between ALE index and adolescents’ overweight/obesity by urban and rural areas. Accounting for the potential role of lifestyle and socio-economic characteristics is key for future research, as understanding the underlying pathways of this association is necessary to design effective interventions.
 ConclusionFindings can help us develop a better understanding of associations between the built environment and overweight/obesity status to inform evidence-based planning policy and practice strategies on how to modify the built environment to promote child health in future generations by increasing better opportunities for diet and activity.

Development of a model for studying the developmental consequences of oxidative sperm DNA damage by targeting redox-cycling naphthoquinones to the Sertoli cell population.

Oxidative stress can be induced in the testes by a wide range of factors, including scrotal hyperthermia, varicocele, environmental toxicants, obesity and infection. The clinical consequences of such stress include the induction of genetic damage in the male germ line which may, in turn, have serious implications for the health and wellbeing of the progeny. In order to confirm the transgenerational impact of oxidative stress in the testes, we sought to develop an animal model in which this process could be analysed. Our primary approach to this problem was to induce Sertoli cells (robust, terminally differentiated, tissue-specific testicular cells whose radioresistance indicates significant resistance to oxidative stress) to generate high levels of reactive oxygen species (ROS) within the testes. To achieve this aim, six follicle-stimulating hormone (FSH) peptides were developed and compared for selective targeting to Sertoli cells both in vitro and in vivo. Menadione, a redox-cycling agent, was then conjugated to the most promising FSH candidate using a linker that had been optimised to enable maximum production of ROS in the targeted cells. A TM4 Sertoli cell line co-incubated with the FSH-menadione conjugate in vitro exhibited significantly higher levels of mitochondrial ROS generation (10-fold), lipid peroxidation (2-fold) and oxidative DNA damage (2-fold) than the vehicle control. Additionally, in a proof-of-concept study, ten weeks after a single injection of the FSH-menadione conjugate in vivo, injected male mice were found to exhibit a 1.6 fold increase in DNA double strand breaks and 13-fold increase in oxidative DNA damage to their spermatozoa while still retaining their ability to initiate a pregnancy. We suggest this model could now be used to study the influence of chronic oxidative stress on testicular function with emphasis on the impact of DNA damage in the male germ line on the mutational profile and health of future generations.

Turkish Consumers’ Perceptions of Organic Milk and the Factors Affecting Consumption: The Case of Kocaeli, Türkiye

The supply of organic products is critical in ensuring sustainable consumption in the face of increasing world population. The increasing awareness of individuals about healthy eating and re-liable food also increases the demand for organic products. The most commonly consumed product group among organic products, after fruits and vegetables, is milk and dairy products. This study aims to determine the perception of organic milk and the factors affecting organic milk consumption by consumers in the city center of the Kocaeli province. The data of the study were collected from 384 consumers with a survey using proportional sampling. The primary material of the study consisted of the data collected by the face-to-face survey method from milk consumers living in the center of Kocaeli province. The study demonstrated their sociodemographic structure with frequency distributions in the data obtained. In addition, statistical analysis methods, such as the chi-squared test and t-test factor analysis, were used for data evaluation. According to the research results, the rate of organic milk consumers was 78.91%. In addition, consumers stated that organic milk was expensive, tasty, and not widely available. Moreover, the most commonly consumed organic dairy products were yogurt, butter, and cheese. The factors influencing consumers about organic milk consumption were price, availability, reliability, and awareness. Increasing the consumption of organic milk is critical for ensuring sustainable consumption and the health of future generations. These results clearly demonstrate that we can increase organic milk consumption in Türkiye and create a fairer and more sustainable organic milk market by ensuring producers follow policies supporting organic milk production, investing in education, and organizing awareness programs for Turkish consumers.

Sharing Intergenerational Food Stories on the Land and Online to Engage Mi’kmaw Children in Indigenous Food Sovereignty

Introduction: Within Indigenous cultures, stories about food and health have been shared on the land because the land, air, water, and ice are where food naturally grows and exists. Yet, Indigenous children are increasingly using online technologies to gather knowledge and share stories with their communities. Objectives: Through analyzing a storytelling session led by a Mi’kmaw Knowledge Keeper, this paper explores how land-based learning can come together with online technology to engage children in Indigenous food sovereignty. Methods: This study is situated within an intergenerational Mi’kmaw foods project called the Land2Lab Project and is guided by Two-Eyed Seeing and decolonial theory. We used narrative inquiry to explore a Knowledge Keeper’s storytelling session that was conducted with 14 Mi’kmaw children. Results: Through this study we learned that we can prioritize Mi’kmaw knowledge both on the land and online. Yet, spending time on the land intergenerationally learning about Mi’kmaw foodways is imperative to maintaining Mi’kmaw food knowledge and engaging children in Indigenous food sovereignty. Conclusion/Discussion: While online technology may seem paradoxical to land-based learning, some elements of intergenerational storytelling can happen online and on the land, and both can be used to support the protection of Mi’kmaw knowledge systems, foodways, and health for future generations.

Determinants of Lung Cancer Screening in a Minnesota Urban Indigenous Community: A Community-Based, Participatory, Action-Oriented Study.

Secondary prevention of lung cancer through screening is potentially lifesaving considering that overall survival of lung cancer is 20% at 5 years but curable if detected at an early stage. This work provides insight into culturally tailored approaches to implementing the service in individuals at high risk of the disease.

Метаболический синдром и ожирение у детей как социально-гигиеническая проблема

The problem of pediatric obesity focused on risk factors at early stages because their modification can reduce the risk of later metabolic diseases and disability. It is the metabolic syndrome that describes a set of cardiometabolic risk factors, including abdominal obesity, insulin resistance, elevated blood pressure, high level of triglycerides and low level of high-density lipoproteins that increase the risk of cardiovascular diseases and type 2 diabetes mellitus. Obesity mainly determines statistical values that characterize the case with endocrine gland diseases among children and adolescents in the Republic of Tatarstan. Obesity is not growing at the same rate any more. The current level of excessive weight in children is too high and requires intervention at the level of the community and school. Inactivity and non-rational nutrition can contribute to formation of excessive body mass among children. Regular physical activity and better nutrition of adolescents is a worthy investment in the health of future generations.

Monitoring the Consumption of Vegetables among OECD Countries, Including Japan.

Increasing intakes of vegetables are associated with risk reduction in various non-communicable diseases, especially cardiovascular disease. In order to compare the proportion of daily vegetable intake among adults from these 30 Organization for Economic Co-operation and Development (OECD) countries as well as Japan, we applied data from the OECD website and the 2017 National Health and Nutrition Survey, Japan (NHNS-J). The figures for Australia, Israel, Korea, New Zealand, and the United States exceeded 80%, where survey questions in these countries asked the amount of intake, instead of the frequency of intake. In Japan, results from the one-day dietary record showed that 99.2% of adults consumed vegetables on the survey day; however, this decreased to 66.3% when assessed by a qualitative question. Proportion of daily vegetable intake as well as average intake amount was higher among those aged 60 y or older. Health policies to increase vegetable intake should target younger age groups to promote health in future generations, in Japan.

Pesticides as endocrine disruptors: programming for obesity and diabetes.

Exposure to pesticides has been associated with obesity and diabetes in humans and experimental models mainly due to endocrine disruptor effects. First contact with environmental pesticides occurs during critical phases of life, such as gestation and lactation, which can lead to damage in central and peripheral tissues and subsequently programming disorders early and later in life. We reviewed epidemiological and experimental studies that associated pesticide exposure during gestation and lactation with programming obesity and diabetes in progeny. Maternal exposure to organochlorine, organophosphate and neonicotinoids, which represent important pesticide groups, is related to reproductive and behavioral dysfunctions in offspring; however, few studies have focused on glucose metabolism and obesity as outcomes. We provide an update regarding the use and metabolic impact of early pesticide exposure. Considering their bioaccumulation in soil, water, and food and through the food chain, pesticides should be considered a great risk factor for several diseases. Thus, it is urgent to reformulate regulatory actions to reduce the impact of pesticides on the health of future generations.

Pediatric obesity and anesthetic challenges of metabolic surgery.

Obesity in the pediatric population is considered a growing problem. It is likely that there will be a significant impact related to obesity on the health of future generations. Obesity has increased the incidence of a spectrum of diseases ranging from microvascular complications over the retina and peripheral nerves to an increased incidence of cancer. We have conducted an electronic search in MEDLINE, PubMed, ISI Web of Science, and Scopus scientific databases targeting studies published between 2000 till 2019. Several modalities have shown a wide spectrum of the effectiveness of weight control among adolescents. Despite achieving short-term success among obese adolescents, maintaining such change is challenging. The emergence of metabolic or bariatric surgeries has opened the door for long-term control over weight gain with considerable remission of unfavorable metabolic mediated or modulated effects associated with obesity such as diabetes mellitus and hypertension. The most commonly practiced metabolic surgery among adolescents is sleeve gastrectomy which is associated with comparable weight and metabolic control and a lesser risk of complication. Anesthesia is considered a major challenge among the pediatric population, especially those with significant obesity. Preoperative evaluation is always warranted to exclude and manage different associated comorbidities. The anesthetic challenges associated with pediatric obesity begin with intubation. Maintenance and emergence from anesthesia along with postoperative antiemetics and analgesia can pose additional challenges. Managing the postoperative period is considered a cornerstone in the early detection and management of any postoperative complication. Especially those complications related to the metabolic and nutritional aspects of the bariatric surgery. Finally, despite being a valuable option in managing obesity, bariatric surgery in adolescents comes with significant anesthetic challenges that need to be consistently evaluated and managed.

Preferences of women with a vulnerable health status towards nudging for adequate pregnancy preparation as investment in health of future generations: a qualitative study

BackgroundWomen with a vulnerable health status, as determined by a low socioeconomic status and poor lifestyle behaviours, are at risk for adverse pregnancy outcomes. Offering tailored preconception lifestyle care can significantly help to improve pregnancy outcomes. We hypothesize that so-called ‘nudges’ can be a successful way of increasing the uptake of preconception lifestyle care. A nudge is a behavioural intervention that supports healthy choices by making them easier to choose. Nudging, however, raises many moral questions. Effectiveness and respect for autonomy are, among other criteria, required for a nudge to be morally permissible. In general, the target group knows best what they find permissible and what would motivate them to change their lifestyle. Therefore, this study – conducted in women with a vulnerable health status – aimed to identify their preferences towards a nudge, provided via a mobile application that aims to help them adopt healthy lifestyle behaviours by offering rewards. MethodsWe conducted semi-structured interviews with twelve women with a vulnerable health status. A framework approach was used to analyse the data. A thematic content analysis was conducted on five themes: (1) “Usefulness of an app as an integral information source”, (2) “Permissibility and effects of offering rewards”, (3) “Preferences regarding content”, (4) “Preferences regarding type of rewards and system of allocation”, and (5) “Barriers”.ResultsOf the 12 participants, 11 deemed an app as integral information source concerning the preconception period useful. None of the participants objected to being nudged i.e., being rewarded for healthy behaviour. All participants stated that they would like the app to contain information on healthy nutrition and 8 participants wanted to know how to get pregnant quickly. Furthermore, participants stated that the freedom to choose the timing and content of the reward would increase the probability of successful behavioural change, and having to pay or contact a healthcare provider to access the app may prevent women using the app.ConclusionsThese insights into the preferences of women with a vulnerable health status towards nudging will inform the design of an effective app-based nudge. This may help to improve prepregnancy health as investment in health of current and future generations.

First effects of the COVID-19 pandemic: pregnancy complications, newborn health and expected reproductive losses

Introduction. The pandemic of the novel coronavirus infection COVID-19 (NCI) has posed a number of questions for humanity, starting with the impact of the infection on the ability of fetation in a couple, pregnancy outcomes, its complications, and ending with the impact on the health of future generations, including the reproductive one.Aim. To analyze the register of pregnant women and newborns in the Amur Region with NCI to identify immediate complications of pregnancy and the neonatal period.Materials and methods. An analysis was made of the registry of pregnant women (n=966) with NCI, newborns from mothers with NCI (n=111) and infected from family members (n=21) in the period from May 1, 2020 to January 1, 2022. A general clinical study of pregnant women and newborns was performed, as well as an analysis of the vaccination of women registered for pregnancy in 2022. Standard statistical data processing methods were used.Results. 966 women were registered who underwent NCI during pregnancy, which accounted for 6.13% of all births, of which in 2020 – 16.9%, in 2021 –83%. In the Amur Region, the maternal mortality rate, as in the Russian Federation, increased during the pandemic and amounted to 38.2 in 2020, and 68.1 per 100 000 population in 2021; particularly from COVID-19 in 2020 – 12.8, in 2021 – 40.9 per 100 thousand population. At the same time, 17.8% had an asymptomatic course of the disease, 63.4% had a mild course, 17.7% had a moderate course, and 11.14% had a severe course with pathological changes in the lungs. The risk of lung tissue damage was increased by infection in the third trimester of pregnancy (RR – 1.73; 95% CI: 1.04-2.9), age over 30 years (RR – 1.24; 95% CI: 1.01-1 .53), overweight (RR –1.8; 95% CI: 1.5–2.14), and obesity (RR – 1.53: 95% CI: 1.2–1.8). The risk of developing complications of pregnancy significantly increased in women with pathological changes in the lungs (moderate and severe course), in comparison with pregnant women with mild NCI. It was found that 14.4% of newborns from mothers with NCI were born prematurely, 3.6% – in moderate asphyxia. The vertical transmission path was not registered in any case. In 33% of children infected in the neonatal period, NCI proceeded in the moderate, in 67% – in mild severity. Only one in three pregnant women are currently vaccinated. Of these, at the stage of preconception preparation, 77%, during pregnancy – 23%.Conclusion. NCI is a factor in the severe course of the disease and the development of pregnancy complications in women with pathological changes in the lungs, which increases the risk of maternal and infant mortality.