The objective was to measure the three aspects of burnout-emotional exhaustion, depersonalization, and reduced personal accomplishment-using the Maslach Burnout Inventory in a sample of health maintenance organization (HMO) pharmacists. The specific objectives were to: 1) investigate the relationship of individual demographic and job-related variables and a career-related variable to the three aspects of burnout; 2) obtain a profile of the respondents susceptible to the three aspects of burnout; and 3) solicit comments from the respondents about the pharmacist's job environment and suggestions to improve it. A survey was mailed to 251 pharmacists practicing in HMO settings from a list supplied by Medicom International, Inc. The survey collected information about burnout in terms of emotional exhaustion, depersonalization, and reduced personal accomplishment; information on the individual and career- and job-related characteristics of each respondent; and comments about the HMO pharmacists' job environment and suggestions to improve it. Eighty-three useable responses were obtained, representing a useable response rate of 33.6%. Overall, the respondents experienced moderate levels of emotional exhaustion and depersonalization, and high levels of personal accomplishment. Staff pharmacists had significantly higher emotional exhaustion and depersonalization scores than those in a supervisory capacity. Unmarried respondents with lower annual salaries had significantly higher emotional exhaustion and depersonalization scores than married/higher-salaried pharmacists, respectively. Respondents with three or more children had lower depersonalization levels than those with no children, while those who had worked for five years or more in their current job had higher emotional exhaustion scores than those who had worked in their current job for fewer years. Respondents who worked between 35 and 40 hours per week in the HMO setting had higher personal accomplishment scores than those who worked 34 hours or less per week. Profiles of pharmacists most susceptible to the three aspects of burnout were obtained: those who had no children, an annual salary of $49,999 or less, and worked for five or more years in their current job were more susceptible to emotional exhaustion. Respondents who had no children and an annual salary of $49,999 or less were more susceptible to depersonalization. Those who spent 1 %-25% of their time processing prescriptions were less susceptible to burnout, while those who worked 34 hours or less were more susceptible to burnout on the personal accomplishment subscale. Results concerning the relationship of individual, job-related, and a career-related variable to the three aspects of burnout were obtained. A profile of HMO pharmacists susceptible to the three aspects of burnout was also obtained. This information can be useful in the development of stress management programs designed to minimize the level of chronic stress that can potentially lead to burnout among HMO pharmacists.