Implications For Human Health Research Articles

Microplastic contamination of food

Microplastic food contamination has become a growing concern due to its potential impacts on human health. Microplastics are tiny plastic particles less than 5mm in size that can originate from various sources, such as cosmetics, textiles, and plastic packaging. These particles can enter the food chain through multiple routes, such as the environment, food processing, and packaging. They can accumulate in different types of food, including seafood, drinking water, and agricultural produce. Exposure to microplastics through food consumption is a significant concern, as it is difficult to avoid and can potentially cause adverse health effects. Microplastics can accumulate in the human body and have been linked to various health issues, such as inflammation, organ damage, and the disruption of endocrine and immune systems. Additionally, microplastics can act as vectors for harmful chemicals and pathogens, further exacerbating their potential health impacts. Several studies have documented the presence of microplastics in different food products, with varying concentrations depending on the type of food and its origin. Due to their filter-feeding behaviour, contamination levels are exceptionally high in seafood, such as fish and shellfish. Additionally, studies have found microplastics in bottled and tap water, beer, honey, salt, and even air. Efforts to mitigate microplastic contamination of food include developing better waste management practices, promoting biodegradable and compostable packaging, and improving food processing methods. However, much more research is needed to fully understand the extent of microplastic contamination in food and its potential impacts on human health. Microplastic contamination of food is a complex issue requiring a multidisciplinary approach to address its ecological and human health implications fully. By raising awareness and promoting sustainable practices, we can work towards reducing our exposure to microplastics in food and protecting public health.

Unraveling of Multifactorial Etiology and Risk Factors of Severe Anemia HB ≤ 6 g/dL

Background: Anemia is an alarming worldwide health condition affecting individuals from modernized and countries that underdeveloped, with significant implications for human health and socio-economic development. Aims: This research aimed to find the primary risk factors linked with severe anemia (HB ≤ 6 g/dL) and assess the relative contribution of different factors, including nutritional status, chronic diseases, infections, and genetic factors. Methodology: A cross-sectional study investigated the fundamental causes and risk factors of disease anemia (HB≤ 6 g/dL). The following study was conducted at the Abbas Institute of Medical Sciences, Muzaffarabad AJK Pakistan. The data was collected through a nonprobability purposive sampling technique. Multivariate analysis was applied using logistic regression to identify specific risk factors for severe anemia. Results: The mean age of the patients was 34.2 years (SD 10.8), with 60% from low socioeconomic status. The mean iron level was 30.4 (SD 12.5) and the mean vitamin B12 level was 190.3 pg/mL (SD 2.3). 46.7% had a history of chronic diseases, with 20.0% having type 2 diabetes and 13.3% having renal diseases. 26.7% were suffering from infections. Chronic disease history significantly increases the risk (OR 2.50, p=0.004). Conclusion: The study population had low hemoglobin and iron levels, with a high proportion of patients having chronic diseases. Severe anemia was significantly associated with low iron levels and Vitamin B12 deficiency, chronic diseases, and infections, increasing the risk of severe anemia

Microbiota in the ptarmigan intestine—An Inuit delicacy and its potential in popular cuisine

The consumption of prey intestines and their content, known as gastrophagy, is well-documented among Arctic Indigenous peoples, particularly Inuit. In Greenland, Inuit consume intestines from various animals, including the ptarmigan, a small herbivorous grouse bird. While gastrophagy provides the potential to transfer a large number of intestinal microorganisms from prey to predator, including to the human gut, its microbial implications remain to be investigated. This study addresses this gap by investigating the microbial composition of the Greenlandic rock ptarmigan’s gastrointestinal tract by analyzing the crop, stomach, and intestines while also comparing it with the microbiota found in garum, a fermented sauce made from ptarmigan meat and intestines. Through 16S rRNA gene sequencing, we assessed whether garum made from ptarmigan intestines provides access to microbial diversity otherwise only accessible through gastrophagy. Our findings reveal that garum made from ptarmigan intestines displayed distinct flavors and microbial composition similar to that found in the ptarmigan gut and intestines, highlighting the potential role of fermented products in mediating food microbial diversity associated with Indigenous food practices. Furthermore, our study underscores the broader importance of understanding microbial diversity in different food systems, particularly in the context of shifting dietary patterns and concerns about diminishing food microbial diversity. By elucidating the microbial richness gained through gastrophagy this research contributes to a deeper understanding of traditional and Indigenous foodways and their implications for human gut health.

The Global Challenge of Fluoride Contamination: A Comprehensive Review of Removal Processes and Implications for Human Health and Ecosystems

Water resources are vital for humanity, but their quality has degraded in recent years due to increasing industrial activities. One significant issue is fluoride contamination, prevalent worldwide. Fluorides exist in combined states such as calcium fluoride, fluorapatite, and cryolite, originating from industrial processes like aluminum and fertilizer manufacturing. The World Health Organization warns against fluoride levels above 1.5 mg/L in drinking water due to health risks, including dental and skeletal fluorosis. Industrial activities also release fluoride-containing wastes into the environment, endangering ecosystems and human health. Overexposure to fluoride leads to disorders affecting organs including the kidneys, liver, and nervous system. Despite fluoride’s benefits in controlled doses, excessive intake causes health problems, as evidenced by rising dental fluorosis cases in Brazil. Thus, effective and affordable fluoride removal strategies are crucial. Various methods exist, including adsorption, membrane technology, ion exchange process, electrodialysis, and electrocoagulation. Regulation of fluoride levels in drinking water is imperative to safeguard public health from its detrimental long-term effects.

Arsenic Contamination in Sludge and Sediment and Relationship with Microbial Resistance Genes: Interactions and Remediation

Arsenic contamination in sludge and sediment has emerged as a pressing environmental issue with far-reaching implications. This review delves into the multifaceted problem of arsenic contamination, focusing on its complex interactions with microbial resistance genes (MRGs). It explores the key role of microorganisms in the biogeochemical cycling of arsenic, including processes such as reduction, oxidation, methylation, and volatilization. It describes how microorganisms resist arsenic through resistance genes that encode proteins such as efflux pumps, enzymatic detoxification, and intracellular sequestration. Arsenic, a naturally occurring element, can enter sludge and sediment through various natural and anthropogenic pathways, leading to detrimental effects on environmental quality. Understanding the role of microorganisms in arsenic mobilization, transformation, and their ability to resist arsenic toxicity through MRGs is essential for effective mitigation and remediation strategies. This review discusses the sources and distribution of arsenic in sludge and sediment, the intricate mechanisms of microbial arsenic resistance, and the potential implications for environmental management and human health. It also examines current research trends and identifies areas requiring further investigation. By unraveling the interplay between arsenic contamination, microorganisms, and MRGs, this review aims to contribute to a deeper understanding of the issue and guide future research and environmental protection efforts.

Dairy consumption: effects on human health and ethical implications for animal welfare

Dairy consumption: effects on human health and ethical implications for animal welfare

Fermented soy products: A review of bioactives for health from fermentation to functionality.

The increasing prevalence of metabolic diseases and the global drive toward achieving Sustainable Development Goals (SDGs) underscore the need for sustainable, nutrient-dense foods. Soybeans (Glycine max), a critical global crop, offer promising solutions; however, their predominant use as animal feed raises concerns regarding food security and environmental sustainability. Fermented soy products-including tempeh, natto, and miso-are rich in bioactive compounds such as peptides and isoflavones, which offer potential therapeutic effects and hold cultural and nutritional significance. These fermented products provide bioactive profiles with unique health-promoting properties. This review critically examines the bioactive compounds generated through fermentation, focusing on their bioconversion pathways in the gastrointestinal tract and their metabolic implications for human health. Recent consumer demand for novel food ingredients with additional biological benefits has fueled research into advanced extraction techniques, enhancing the functional applications of bioactive compounds from these soy-based products. This review further explores innovations in extraction methods that improve bioactive yield and sustainability, reinforcing the applicability of these compounds in health-promoting food interventions. The originality of this review lies in its in-depth exploration of the gastrointestinal bioconversion of fermented soy bioactive compounds alongside the latest sustainable extraction methods designed to optimize their use. Future research should aim to refine fermentation and extraction processes, investigate synergistic microbial interactions, and develop environmentally sustainable production methods. These efforts have the potential to position fermented soy products as essential contributors to global nutritional security and sustainable food systems, addressing both public health and environmental needs.

Organophosphate pesticide residues in fruits and vegetables in Nigeria: prevalence, environmental impact, and human health implications.

Pesticides have become indispensable in modern agriculture, aiding in crop protection, and ensuring food security. However, their extensive use has raised concerns about environmental contamination and human health risks. This manuscript reviews the prevalence of organophosphate pesticide (OPP) use in Nigerian agriculture and explores methods for detecting pesticide residues in fruits and vegetables. Despite the critical role of pesticides in safeguarding crop yields, the lack of regulatory enforcement and monitoring in Nigeria poses significant challenges. The review underscores the importance of understanding the health implications of pesticide residues in food. While acute and sub-chronic health effects of OPP exposure have been studied, there remains a need for a focused review of the long-term impacts, particularly in the context of limited regulatory oversight. Additionally, the manuscript highlights gaps in knowledge regarding the effects of pesticides on biodiversity, ecosystems, and vulnerable populations such as children, pregnant women, and the elderly. Recommendations include longitudinal studies to assess cumulative and delayed health consequences, systematic reporting of poisoning incidents, and routine analysis of food products to ensure safety. By addressing these gaps, a more comprehensive understanding of the consequences of OPP usage in Nigeria can be achieved, facilitating the development of effective risk management strategies to protect both the environment and public health.

The Effects of Heat Stress on the Ovary, Follicles and Oocytes: A Systematic Review.

Climate change is driving significant environmental changes with profound implications for human health, including fertility. While the detrimental effects of heat on spermatogenesis are well-documented, the impact of elevated temperatures on ovaries and female fertility remains less explored. This review systematically examines the literature on heat stress (HS) effects on mammalian ovaries, follicles, and oocytes. Evidence from mammalian models indicates that HS significantly impairs ovarian function, disrupting hormone profiles, reducing ovarian size and weight, altering histology, decreasing granulosa cell viability, and compromising oocyte quality. Efforts to develop strategies and substances to mitigate these adverse effects are ongoing, but further research into the underlying mechanisms is urgently needed.

Betalains: A Narrative Review on Pharmacological Mechanisms Supporting the Nutraceutical Potential Towards Health Benefits.

Betalains are naturally occurring pigments sourced mainly from Beta vulgaris (beetroot), Hylocereus spp. (dragon fruit), Amaranthus spp., and Opuntia spp. Betalains are widely used for their vibrant colors and health-promoting properties. These nitrogenous, water-soluble pigments are crucial colorants in the food industry, responsible for the red, purple, and yellow plant tissues, predominantly in the order Caryophyllales. They are grouped into betacyanins, with reddish-violet hues, and betaxanthins, yellow to orange. Examples include beetroot stems for betacyanins and yellow pitaya pulp for betaxanthins. Several pharmacological activities were reviewed in the scientific literature, describing their potential implications for human health. In this review, we focused on the main and latest studies on the pharmacological effects and mechanisms of betalains, including antioxidant, anti-inflammatory, antihypertensive, hypolipidemic, antidiabetic, hepatoprotective, neuroprotective, anticancer, and antimicrobial properties, in both in vitro and in vivo studies. Overall, betalain consumption is considered safe, with no major adverse effects or allergic reactions reported. We also approached topics such as the pharmacokinetics, bioavailability, stability, and enhanced stabilization of betalains. This article provides a comprehensive overview of bioactive potential of betalains, highlighting the biochemical mechanisms involved. The current knowledge broadens the clinical applicability of betalains, making them potential sources of nutraceutical compounds that can be used to develop functional foods.

Lanthanum and cerium added to soil influence microbial carbon and nitrogen cycling genes

The soil microbiome plays an important role in carbon (C) and nitrogen (N) processing and storage and is influenced by rare earth elements (REEs), which can have both direct and indirect effects on plant metabolic processes. Using conventional physicochemical methods and metagenomic-based analyses, we investigated REEs effects on soil respiration, soil mineral N, soil microbial community structure and functional genes related to C and N metabolism. High doses of cerium (0.16 and 0.32 mmol kg−1 soil) increased CO2 net production rate by 59 and 42%, and N2O net production rate by 255 and 609%, respectively, compared to no REEs. Similarly, high doses of lanthanum (0.16 and 0.32 mmol kg−1 soil) increased CO2 net production rate by 47 and 39%, and N2O net production rate by 105 and 187%, respectively. Increased soil respiration from altered relative abundances of key soil microorganisms associated with soil N cycling and organic matter degradation and functional genes encoding enzymes involved in C and N metabolism, accelerated N mineralization. Elevated REEs levels substantially increased the relative abundances of functional genes related to cellulose, chitin, glucans, hemicellulose, lignin, and peptidoglycan degradation. REEs also influenced multiple functional genes associated with the N cycle. The abundance of genes responsible for organic N degradation and synthesis, such as asnB, gdh_K15371, glsA, and gs, increased with elevated cerium and lanthanum concentrations. Similarly, the abundances of denitrification genes, including narl, narJ, narZ, and nosZ, also rose with increasing amounts of cerium and lanthanum. However, the decrease in narB and nirB gene abundance with increasing REE concentrations was attributed to the reduction of nitrate to amino groups. Our findings highlight the influence of REEs on key soil microorganisms associated with soil N cycling and organic matter degradation and key functional genes in soil C and N metabolism, with implications for agriculture, environmental protection, and human health.

Impact of Metabolites from Foodborne Pathogens on Cancer.

Foodborne pathogens are microorganisms that cause illness through contamination, presenting significant risks to public health and food safety. This review explores the metabolites produced by these pathogens, including toxins and secondary metabolites, and their implications for human health, particularly concerning cancer risk. We examine various pathogens such as Salmonella sp., Campylobacter sp., Escherichia coli, and Listeria monocytogenes, detailing the specific metabolites of concern and their carcinogenic mechanisms. This study discusses analytical techniques for detecting these metabolites, such as chromatography, spectrometry, and immunoassays, along with the challenges associated with their detection. This study covers effective control strategies, including food processing techniques, sanitation practices, regulatory measures, and emerging technologies in pathogen control. This manuscript considers the broader public health implications of pathogen metabolites, highlighting the importance of robust health policies, public awareness, and education. This review identifies research gaps and innovative approaches, recommending advancements in detection methods, preventive strategies, and policy improvements to better manage the risks associated with foodborne pathogens and their metabolites.

Identification of a PET hydrolytic enzyme from the human gut microbiome unveils potential plastic biodegradation in human digestive tract.

Widespread use of polyethylene terephthalate (PET) plastics and their recycling challenges have led to substantial accumulation of PET wastes in global environments, with inevitable consequences for their entry into the food chains. Recent studies have increasingly documented the ingestion of microplastics by humans through food and beverages. However, the fate of these microplastics within the gastrointestinal tract, particularly the role of the human gut microbiota, remains inadequately understood. To address this knowledge gap, we employed a bioinformatics workflow integrated with functional verification to investigate the PET digestion/degradation capabilities of intestinal microorganisms. This approach identified a novel PET hydrolase-HGMP01 from the human gut metagenome, which exhibits the capacity to hydrolyze PET nanoparticles. Moreover, comprehensive exploration for HGMP01 homologues in the human gut metagenome and metatranscriptome unveil their distribution in diverse intestinal microorganisms. This study provides biochemical evidence for an unforeseen role of human gut microbiome in plastic digestion, thus holding substantial implications for human health.

CHARTING THE UNSEEN: EXPLORING THE EFFECTS OF EPIGENETIC MODIFICATIONS ON SPERM AND THEIR ROLE IN MALE INFERTILITY

Objective: This study aims to review existing literature on the impact of epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNA, on gene expression and their implications for human health and disease mechanisms. Methods: A literature review was conducted between January 2023 and October 2024, analyzing nine selected studies that explored the relationship between epigenetic mechanisms and gene expression in patients with various conditions, such as heart disease and cancer. Key methodologies discussed include RNA sequencing (RNA-Seq) for quantifying gene expression, chromatin immunoprecipitation sequencing (ChIP-Seq) for protein-DNA interaction analysis, and DNA microarray analysis for genome-wide gene expression profiling. Results: The findings highlight that DNA methylation suppresses gene expression by chemically modifying DNA, histone modifications alter chromatin structure to regulate gene accessibility, and non-coding RNAs influence transcription and translation processes. The interplay among these mechanisms was shown to regulate gene expression without requiring genetic mutations, resulting in diverse biological outcomes. The review also discusses the role of daily nutrition, potential complications, and therapeutic strategies targeting epigenetic modifications. Novelty: This study underscores the critical role of epigenetic changes in modulating gene expression and provides insights into their potential for advancing the understanding of disease mechanisms and developing novel approaches for diagnosis, treatment, and prevention.

Assessment of heavy metal concentrations, environmental risks and human health implications in marine sediments along the coastal ecosystems of the Republic of Congo.

The aim of this study is to assess the level of heavy metals (HMs) in surface sediments along the coastal estuaries of the Republic of Congo. A variety of approaches were employed, integrating elemental analysis (Atomique Absorption Spectroscopy), environmental, ecological, health risk assessment, and source identification techniques to evaluate the distribution, origin, environmental, ecological and health risks of potentially toxic element (PTE) contamination in sediments. The ascending mean concentration (mg/kg) of Cd (0.4) < Cu (18.6) < Pb (28.8) < Zn (62.1) < Mn (107) < Mg (569.6) complied with the local background, except for Cd and Pb. However, notable variations across sampling points and sites were observed, with a strong relationship between metals and organic matter. The comparing of PTEs with USEPA international standards and sediment toxicity guidelines showed compliance. The assessment of environmental risk parameters, based on the calculation of the geo-accumulation index, concentration factor and pollutant load indices showed low pollution of sediments. The ecological risk assessment, on the other hand, revealed a low level of pollution of biota and a low toxicity risk of ecosystems related to Cd and Pb and then to Cu in some sites. Regarding human health risk assessment, related to the PTEs, the cancerogenic effect indices were calculated for Cd and Pb through ingestion and inhalation pathways, and the non-cancerogenic effect indices were calculated for all HMs through ingestion, inhalation, and cutaneous contact routes, for children and adults, and showed that the results comply with the international standards set by USEPA, ranging from 10-4 to 10-6 and less than 1, respectively, where children were more sensitive and vulnerable than adults to the effects of the PTEs. Ultimately, this study revealed sediment lithology, anthropogenic activities, and mixed origins of HMs, with a large contribution from industrial activities. However, no significant impacts are discernible in the study area. In addition to the importance of this study, it forms part of the region database and could serve as a reference for future monitoring studies, since no data are available in th Congolese coastal environment.

Microplastics in Morocco's most consumed fisheries: Chemical characterization, ecological traits, and implications for human health

The pervasive presence of microplastics (MPs) in the environment is well established, yet many critical questions remain about their distribution and potential impacts on both ecological and human health. To assess the risks that MPs pose, especially through marine ecosystems and human consumption, monitoring their ingestion by fish in natural environments is essential. This study investigated the contamination of 12 fish species, the most commonly consumed in Morocco, collected from the Atlantic Ocean off the Moroccan coast. Analysis of 240 fish (20 individuals per species) revealed that 100 % of the samples contained microplastics. MPs were detected in the gills, gonads, and gastrointestinal tracts of all 12 species. The average abundance of microplastics per fish ranged from 20.6 to 133.2 MPs, with the forms identified as fragments (60 %), fibers (30 %), films (8 %), and pellets and foams (1 %). Additionally, omnivorous and demersal species presented the highest levels of MP contamination. Infrared spectroscopy (ATR-FTIR) analysis identified seven polymers, with high-density polyethylene (34 %), polyethylene terephthalate (30 %), and polypropylene (17.5 %) being the most prevalent. The microplastics were predominantly dark or light in color, with a notable presence of red and blue particles. Fish ingest various sizes of microplastics, primarily particles smaller than 1 mm. Scanning electron microscopy coupled with energy dispersive X-ray analysis (SEM/EDX) revealed that most MPs exhibited visible signs of weathering and contained inorganic components on their surfaces. The potential risk of MPs to fish, as assessed by the polymer hazard index (PHI), was categorized as level V, indicating that MPs may pose significant risks to human health. The highest estimated daily intake (EDI) of microplastics was found in children (1620 MPs/year), whereas the lowest intake was estimated in women (350 MPs/year) and men (337 MPs/year). Given the widespread presence of microplastics in commonly consumed fish species in Morocco, there is an urgent need for regulatory measures to ensure the safety of fisheries, both for domestic consumption and export. Policymakers should consider the development of guidelines for acceptable levels of microplastic contamination in fish to safeguard public health.

Advances in Soil Amendments for Remediation of Heavy Metal-Contaminated Soils: Mechanisms, Impact, and Future Prospects

Heavy metal contamination is a critical factor contributing to soil degradation and poses significant environmental threats with profound implications for ecosystems and human health. Soil amendments have become an effective strategy to address these challenges by reducing heavy metal hazards and remediating contaminated soils. This review offers a comprehensive analysis of recent advancements in soil amendments for heavy metal-contaminated soils, with a focus on natural, synthetic, natural-synthetic copolymer, and biological amendments. By thoroughly examining and contrasting their remediation mechanisms and effects, this study provides a detailed evaluation of their influence on soil physicochemical properties, leachable heavy metal content, and microbial communities. Through bibliometric analysis, current research priorities and trends are highlighted, offering a multidimensional comparison of these amendments and clarifying their varying applicability and limitations. Furthermore, this review explores future prospects and the inherent challenges in soil amendments for heavy metal contamination, aiming to offer valuable insights and theoretical references for the development and selection of novel, efficient, multifunctional, environmentally friendly amendments.

ENVIRONMENTAL AND HEALTH IMPACTS OF AGRICULTURAL WASTE COMBUSTION FOR BIOENERGY: A TOXICITY AND EMISSION REVIEW

This study examines the environmental and health impacts caused by the release of polycyclic aromatic hydrocarbons (PAHs) from the combustion of biomass and agricultural waste. Today, bioenergy plays a crucial role in global energy systems, accounting for 70 % of renewable energy consumption, 9.5 % of total primary energy supply, and 13 % of global gross final energy consumption. However, environmental pollution remains one of the greatest challenges of the 21st century, with serious implications for human health, biodiversity, and climate change. PAHs, released during the incomplete combustion of organic fuels, are particularly concerning due to their carcinogenic and mutagenic properties. This review aims to evaluate the emissions of PAHs during biomass combustion, with a focus on fuel types and combustion conditions. It synthesizes data from over 30 contemporary scientific sources, comprehensively analysing PAH formation and distribution in flue gases, and identifies the key factors influencing these emissions. The research reveals that PAH emissions vary significantly depending on the type of biomass, combustion conditions, and the control measures employed. Open burning of agricultural residues generates much higher PAH concentrations compared to controlled combustion in stoves or furnaces. The analysis assumes consistent data reporting across studies and acknowledges that real-world conditions may differ from laboratory settings, potentially affecting emission levels. The findings underscore the importance of implementing effective emission control strategies to reduce environmental and health risks, particularly in regions like Ukraine that rely heavily on biomass as an energy source. By addressing a critical gap in the literature, this review enhances understanding of the long-term impacts of bioenergy on environmental health and sustainability and advocates for updating Ukrainian regulatory legislation with modern methodological procedures.

The intratumoral landscape of T cell receptor repertoire in esophageal squamous cell carcinoma

BackgroundEsophageal squamous cell carcinoma (ESCC) is a malignant neoplasm with detrimental implications for human health. The landscape of ESCC therapy has been revolutionized by the introduction of immunotherapy, specifically involving immune checkpoint inhibitors (ICIs). A number of studies have documented the prognostic significance of T-cell receptor (TCR) repertoire and its association with many tumors. Nevertheless, the TCR repertoire landscape and its significance in ESCC still need to be explored.MethodsIn this study, we conducted RNA-Seq analysis to investigate the characteristics of the TCR repertoire in 90 patients. Moreover, high-throughput TCR sequencing was performed on tumor tissues from 41 patients who received immunotherapy. Additionally, a comprehensive analysis of the T-cell receptor repertoire landscape within ESCC tumors was carried out through immunohistochemical staining on all patient samples.ResultsWe noticed a diminished diversity of TCR repertoire within the tumor compared to its adjacent normal tissue. In terms of immunotherapy responses, non-responsive patients exhibited higher TCR repertoire diversity indices and an increased frequency of common V and J genes. Additionally, elevated TCR repertoire diversity correlated with improved overall survival rates. Lastly, immunohistochemical staining results indicated a correlation between TCR repertoire diversity and the tumor immune microenvironment (TIME).ConclusionsOur study primarily describes the landscape of TCR repertoires in ESCC through three aspects: differences in tumor tissues, immune response to immunotherapy, and survival prognosis of patients. These results emphasize the importance of TCR repertoire characteristics as unique and relevant biomarkers for ESCC immunotherapy.

Comparative cardiovascular adaptations in aquatic vs. terrestrial vertebrates: Implications for human cardiovascular health

Comparative cardiovascular adaptations in aquatic vs. terrestrial vertebrates: Implications for human cardiovascular health