Abstract Background: Lesbian, gay, bisexual, transgender, queer, and intersex (LGBTQI+) people living with cancer have unique health considerations that must be assessed to provide high quality, individualized patient care. LGBTQI+ health education materials may play a pivotal role in cancer survivors’ (“persons on a cancer journey”) experiences throughout their cancer care continuum. Methods: We identified 2,500 LGBTQI+ persons on a cancer journey who completed the “OUT: National Cancer Survey,” conducted by the National LGBT Cancer Network in 2020-2021, and classified participants by their self-reported level of satisfaction with their overall cancer care. We examined care satisfaction in relation to patient access to LGBTQI+-tailored health education resources and the influence of gender identity and/or sexual orientation on survivors’ experiences before, during, and after cancer treatment. Results: Most persons on a cancer journey reported lacking access to vital health education resources specific to their LGBTQI+ identities in areas of mental health (70%), physical activity (91%), tobacco cessation (89%), and alcohol consumption (86%), regardless of their satisfaction with overall care. Further, the majority of participants believe it would be valuable to receive tailored LGBTQI+ education materials specifically in areas of mental health (80%) and physical activity (67%), while also incorporating information specific to LGBTQI+ individuals into their post-treatment care plans (74%). Conclusion: LGBTQI+ persons on a cancer journey value information and health education materials that are tailored. Increased access to such materials may have large implications for the satisfaction of LGBTQI+ cancer persons on a cnacer journey with their overall cancer care. Citation Format: Colin Burnett, William Jesdale. Overall satisfaction with cancer care in a lesbian, gay, bisexual, transgender, queer and intersex population [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B112.