You have accessJournal of UrologyUrinary Diversion: Bladder Reconstruction, Augmentation, Substitution, Diversion (I)1 Apr 20131256 OXYGEN RELEASING SUTURE MATERIAL IMPROVES WOUND HEALING IN BOWEL ANASTOMOSIS Roman Inglin, Benjamin Harrison, Lukas Brugger, Tullio Sulser, Daniel Candinas, and Daniel Eberli Roman InglinRoman Inglin Zurich, Switzerland More articles by this author , Benjamin HarrisonBenjamin Harrison Winston-Salem, NC More articles by this author , Lukas BruggerLukas Brugger Zurich, Switzerland More articles by this author , Tullio SulserTullio Sulser Zurich, Switzerland More articles by this author , Daniel CandinasDaniel Candinas Bern, Switzerland More articles by this author , and Daniel EberliDaniel Eberli Zurich, Switzerland More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2610AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES In reconstructive Urology bowel anastomosis remain a clinically highly relevant issue with ischemia/hypoxia identified as a primary reason for anastomotic failure with severe clinical consequences. While supplemental systemic oxygen was shown to increase tissue oxygen tension in perianastomotic tissue, nothing is known about the effect of local application of oxyen on healing of bowel anastomoses. Recently, oxygen-producing biomaterials have been developed for tissue engineering purposes. Using similar technology we have successfully developed an O2-releasing suture material and evaluated its influence on healing of hypoxic bowel tissue. METHODS A PGA suture material was coated with PLGA containing oxygen-producing calcium peroxide (CPO) nanoparticles. To evaluate the limitations of our approach Lewis rats underwent an ischemia induction of a bowel segment that consequently was transected and reunified using O2-producing (group A), untreated (B) or PLGA-coated (C) sutures. Mechanical, physiological and histomorphological measurements were performed, at postoperative day (pod) 1, 3, or 7, respectively. RESULTS Non-invasively measured perianastomotic in vivo tissue oxygen saturation was significantly higher in anastomoses performed with O2-releasing sutures compared to animals of group B and C at all analyzed pod (p<0.05). The mechanical stability was significantly higher in anastomoses using O2-releasing sutures compared to those where PLGA- or untreated suture material was applied (p<0.05). CONCLUSIONS We were able to demonstrate that manufacturing of oxygen-releasing suture materiel is feasible, and that these sutures significantly enhanced perianastomotic tissue oxygen saturation and mechanical stability of bowel anastomoses. Given the high relevance of improved anastomotic healing after bowel surgery for urologic reconstructive procedures, these materials may be used for clinical application in near future. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e514 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Roman Inglin Zurich, Switzerland More articles by this author Benjamin Harrison Winston-Salem, NC More articles by this author Lukas Brugger Zurich, Switzerland More articles by this author Tullio Sulser Zurich, Switzerland More articles by this author Daniel Candinas Bern, Switzerland More articles by this author Daniel Eberli Zurich, Switzerland More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...