Abstract
To investigate whether chitosan application over colonic anastomosis line, provide reinforcement, and subsequently improve anastomotic healing. Forty eight Wistar albino female rats were used and were randomly divided into four groups, 12 rats in each: The control groups (1 and 3) received no further treatment. The experimental groups (2 and 4) received chitosan application over the colonic anastomosis. After sacrifying rats at the end of the experiment (either on day three or on day seven, depending on the group), colonic bursting pressure, a hihydroxyproline level and histopathologic characteristics of the perianastomotic tissue were examined. At three days, chitosan and control groups had similar values for histopathologically. On day seven, chitosan group had significantly higher mean score of collagenization (p=0.007) and a significantly higher bursting pressure (p=0.038). Our study emphasizes the positive effect of chitosan in the process of collagenation in colonic anastomosis healing.
Highlights
Introduction during healing processGastrointestinal anastomoses are among the most frequently performed procedures in general surgery units throughout the world
Change in variables over time In the chitosan group day 3, a significant increase in collagen score (2.25±0.45 vs. 2.33±0.49, 3.42±0.51 p
In control group, a significant time dependent increase was observed in only bursting pressure (192.5±23.8 vs. 61.67±9.37 vs. mmHg, p
Summary
Introduction during healing processGastrointestinal anastomoses are among the most frequently performed procedures in general surgery units throughout the world. The risk of anastomotic leak is highest in the large intestine. The risk is not uniformly distributed in this anatomical location: the more distal the anastomosis in the large intestine the greater the likelihood of anastomotic leak[1,3]. Relative scarcity of collateral circulation together with a very rich bacterial flora may help to explain the higher probability of leaks in this area[4]. Another factor associated with increased risk is the frequent occurrence of coexistent pathologies in most of the patients undergoing colon surgery[5]
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