Immune disorders are observed in chronic renal failure (CRF) patients for many reasons. The immunity to these patients is further increased by the addition of viral agents. HBV and HCV are common infectious agents in kidney patients and effect of oxidative stress. Hsp70 is an extracellularly expressed molecule, although it is essentially an intracellular protein that increases expression in the organism under stress. HSP70 induction is thought to be an adaptive response to increased oxidative stress. In this study, it was aimed to determine Hsp70 in CRF patients diagnosed with HBV and HCV. Samples of 235-patients receiving hemodialysis treatment and 25-healthy individuals were included in the study. Hsp70 was determined using high sensitivity ELISA. The Hsp-70 was found to be higher in non-hepatitis, HBV and HCV patients receiving hemodialysis therapy than those of control. When pre and post dialysis are compared, a minimal increase in post dialysis among HBV, HCV and non-hepatitis groups was observed (p›0.05). To prevent the increase of inflammation and oxidative stress in hemodialysis patients or to keep it under control, investigating certain parameters such as Hsp70 from time to time is of great importance in terms of minimizing the level of risk for many diseases.