This article presents a new design method of energy management strategy with model-free DC-Bus voltage control for the fuel-cell/battery/supercapacitor hybrid electric vehicle (FCHEV) system to enhance the power performance, fuel consumption, and fuel cell lifetime by considering regulation of DC-bus voltage. First, an efficient frequency-separating based-energy management strategy (EMS) is designed using Harr wavelet transform (HWT), adaptive low-pass filter, and interval type–2 fuzzy controller (IT2FC) to determine the appropriate power distribution for different power sources. Second, the ultra-local model (ULM) is introduced to re-formulate the FCHEV system by the knowledge of the input and output signals. Then, a novel adaptive model-free integral terminal sliding mode control (AMFITSMC) based on nonlinear disturbance observer (NDO) is proposed to force the actual values of the DC-link bus voltage and the power source’s currents track their obtained reference trajectories, wherein the NDO is used to approximate the unknown dynamics of the ULM. Moreover, the Lyapunov theorem is used to verify the stability of AMFITSMC via a closed-loop system. Finally, the FCHEV system with the presented method is modeled on a Matlab/Simulink environment, and different driving schedules like WLTP, UDDS, and HWFET driving cycles are utilized for investigation. The corresponding simulation results show that the proposed technique provides better results than the other methods, such as operational mode strategy and fuzzy logic control, in terms of the reduction of fuel consumption and fuel cell power fluctuations.