Goal. Research of the history of formation and stages of activity of the Institute of Plant Protection of the National Academy of Agrarian Sciences of Ukraine, its role in increasing the efficiency of the agro-industrial production of the country, in the scientific and business world.
 Methods. Analysis of archival data on the establishment of the modern Institute of Plant Protection of NAAS, articles on the activities of the institution, scientific works of scientists.
 Results. At all stages of its history, the Institute has successfully solved important tasks related to the development of effective plant protection measures from the most dangerous pests and diseases, in particular the improvement of the chemical method of protection, development and implementation of biological protection measures. The economic expediency of the use of insecticides is theoretically substantiated; the economic thresholds of harmfulness of phytophages, indicators of ecological safety of the chemical method of protection and the theoretical foundations of integrated plant protection from harmful organisms are developed. A huge work on scientific provision of breeding of agricultural plants to resistance against pathogens of diseases and pests is carried out. A set of scientific researches on improving ecological and safe methods of protecting cultures under radioactive contamination are carried out. Systems of monitoring and controlling the number of parasitic phytonematodes on wheat winter, potatoes, sugar beets, vegetable cultures of greenhouse are developed. Numerous scientific researches on quarantine of plants are carried out. There are developments on the forecasting of the beans of field crops and improvement of techniques of use of herbicides. Large-scale researches on wheat genetics are carried out.
 Conclusions. The Institute of Plant Protection of NAAS has always played and now plays a huge role in improving the efficiency of agro-industrial production. It is firmly established in the scientific and business world.
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