Purpose: To report the characteristics and the surgical outcomes of full-thickness macular holes (MHs) accidentally caused by laser devices and analyze the visual predictors. Methods: 33 eyes that underwent vitrectomy for laser-induced MHs were included. Full ophthalmic examinations and optical coherence tomography were used for assessment at baseline and at follow-ups. Preoperative and 6-months postoperative features were analyzed respectively as potential predictors of final visual acuity. Results: 11 eyes were injured by a neodymiumdoped yttrium aluminum garnet (Nd:YAG) laser and 22 by a handheld laser. 5/33 eyes had a focal subfoveal choroidal depression preoperatively. MH closure was achieved in 87.9% eyes. 79.3% eyes had VA improvement of 2 or more lines. Compromised VA improvement was associated with preoperative choroidal depression (P=0.026, odds ratio [OR]=0.068, 95% confidence interval [CI]: 0.006∼0.729). Worse final BCVA was associated with worse preoperative BCVA (P=0.001, regression coefficient [B]=0.497, 95%CI: 0.221∼0.774), preoperative choroidal depression (P=0.014, B=0.353, 95%CI: 0.078∼0.628), Nd:YAG laser injury (P=0.030, B=-0.244, 95%CI: -0.461∼-0.026), larger MH diameter (P=0.023, B=0.031, 95%CI: 0.005∼0.058), failed macular hole closure (P=0.003, B=-0.472, 95%CI: -0.775∼-0.169), larger ellipsoid zone (EZ) defect at 6 months (P=0.002, B=0.053, 95%CI: 0.024∼0.082) and thinner foveal neuroretina thickness at 6 months (P<0.001, B=-0.365, 95%CI: -0.520∼-0.211). Conclusion: Vitrectomy is effective in closing laser-induced MHs and improving visual acuity. Preoperative factors including worse preoperative BCVA, choroidal depression, Nd:YAG laser injury and larger MH diameter and postoperative factors including failed MH closure, larger EZ defect and thinner foveal neuroretina at 6 months are predictive factors for worse final VA.
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