The cover illustration shows a variety of orbital implants that have been used following enucleation. This is discussed by Mourits et al in this issue of ACTA. Prins et al. in the Netherlands review the use of MRI imaging of the brain in eye disease. Structural changes in the visual pathways of the brain are seen in glaucoma, AMD and other eye diseases and might suggest a general neurological disorder. Yassin in Saudi Arabia reviews bleb-related infections following glaucoma filtering surgery. The prognosis is usually good if the infection is limited to the bleb but poor when endophthalmitis develops. de Vries et al. in the Netherlands report that the relatively few patients require glaucoma drainage surgery following vitreoretinal surgery. These patients were more likely to have history of glaucoma, many vitreoretinal operations and silicon oil. Tryggvason et al. in Norway, Iceland and USA examined the hearing of patients with glaucoma and/or exfoliation syndrome. Many individuals have hearing loss, and this was associated with age and male gender but not with glaucoma or exfoliation syndrome. Jonas et al. in Germany report thinning of Bruch's membrane in patients in secondary high axial myopia caused by congenital glaucoma. Timlin et al. in London recommend anterior segment OCT for diagnostic examination of lacrimal puncta. Ringvold and Reubsaet in Norway found that acetylcholine affects corneal epithelial cells in vitro and influences iron channels. Mourits et al. in the Netherlands evaluate complications from different types of orbital implants following enucleation for retinoblastoma. They recommend acrylic implants. Klingenstein et al. in Germany and USA examine microcirculation patterns and suggest that these may guide in differentiating uveal nevi from malignant melanomas. Munch et al. in Denmark and Austria validate the Radner reading chart for reading acuity and speed in a Danish cohort. Breukink et al. in the Netherlands recommend half-dose photodynamic therapy and subthreshold diode micropulse laser for chronic central serous chorioretinopathy. Haas et al. in Austria found no difference in pain during intravitreal injections with 27 and 30 gauge needles. However, 30 gauge needles were preferred by the surgeons. Segal et al. in Israel found an association between anxiety levels and perceived pain during intravitreal injections. Norn documents the history of ophthalmology in Denmark up to 1865. The following articles are published electronically only. They are accessible on www.actaophthalmologica.com, where you can find all published articles of ACTA from the beginning. Kim and Choi in Korea found that early postoperative overcorrection was associated with success in surgical treatment of intermittent exotropia. Creuzot-Garcher et al. in France examined elderly people over 75 years old and found visual impairment (visual acuity <0.3) in 2.3% and increasing to 5.6% in patients over 85 years old. Lee et al. in Korea associated the location of retinal nerve fibre layer defects with peripapillary atrophy in glaucoma patients. Kiliç et al. in Turkey found exfoliation syndrome in 5.7% of a Turkish population and this was associated with advancing age and male gender. Hayes et al. in UK recommend a modification of iontophoresis technique for riboflavin penetration into corneal stroma for cross-linking. Prakash et al. in the United Arab Emirates discuss the differences between central and non-central keratoconus in terms of corneal topography. GamalElDin et al. in Egypt recommend big-bubble technique for Descemet's endothelial grafts. Agrawal et al. in UK and Singapore propose a classification for semi-automated laser flare readings in uveitis. Gupta et al. in Singapore suggest that the visibility of choroidal–scleral interface on OCT images influences choroidal thickness measurements. Fernández-Vigo et al. in Spain found the variation in anterior chamber depth to be associated with age, sex, spherical error, corneal diameter and anterior chamber angle. Njikam et al. in Kenya, Cameroon and Germany report on the epidemiology of diabetic retinopathy in Cameroon. Sansom et al. in UK found an association between systolic blood pressure and ocular perfusion pressure with subfoveal choroidal thickness. Vannozzi et al. in Italy report cytomegalovirus retinitis in a patient who received a dexamethasone implant. Barteselli et al. in Italy and USA report transient structural abnormalities of the retina following intravitreal ocriplasmin injection. Suh and Kee in Korea examined long-term outcome of patients with congenital glaucoma and found that many need reoperation. Mulder et al. in the Netherlands and Belgium suggest shallowing of the anterior chamber to protect the crystalline lens during vitrectomy. Kessel et al. in Denmark discuss early results from preoperative scoring of cataract patients. Mazeikaite et al. in Lithuania and USA report elevated levels of antiphospholipid antibodies in patients with pseudoexfoliation syndrome. Alberti and la Cour in Denmark compare treatment of macular holes with vitrectomy and ocriplasmin. More macular holes are closed after vitrectomy but visual acuity outcomes are similar. Cennamo et al. in Italy recommend transpupillary thermotherapy for choroidal haemangioma. I hope you find This Issue of ACTA informative and interesting.