Comparison of efficacy between focal laser photocoagulation and photodynamic therapy in CSCR

Abstract

AbstractPurpose To evaluate and compare clinical outcomes for patients with acute central serous chorioretinopathy (CSCR) undergoing either focal laser photocoagulation (LPK), photodynamic therapy (PDT) or just observation.Methods In a retrospective, comparative case series study 73 patients (73 eyes) with acute central serous chorioretinopathy of at least 3 months’ duration were recruited. Out of 73 patients 51 were treated with LPK, 10 with half dose PDT and 12 patients have been in the observation group. Patients follow‐ups were conducted every one to two months until complete subretinal fluid resorbtion on OCT was achieved. The main outcome measures were change in BCVA by Snellen and subretinal fluid (SRF) assessed by OCT (Zeiss Stratus OCT).Results The mean age of the patients was 47.76±8.43 years (range 24‐65). 55 of 73 patients were male, 16 were female. The mean BCVA (by Snellen) at baseline was 0.81±0.23 in LPK group, 0.69±0.24 in PDT group and 0.88±0.15 in the non‐treated group. At the last visit, comparing BCVA between LPK and PDT, LPK and non‐treated group and PDT and non‐treated group – there was no statistically significant differences between these groups, p<0.289, p<0.089 and p<0.894 respectively. Comparing the central retinal thickness outcomes by OCT, there was also no statistically significant difference between these groups: LPK and PDT (p<0.387), LPK and non‐treated group (p<0.371), and PDT and non‐treated group (p<0.246).Conclusion Our study did not comfirm that any of the used therapy options is superior to another. At the final visit after treatment no statistically significant difference in anatomical and functional recovery was noted between the two modalities of treatment and observation.