Gray Hair Research Articles

The Effect of Covid-19 on the Hair Diseases Observed in Health Care Providers: Analysis of 513 Participants.

The Covid-19 pandemic has been shown to have major acute and chronic impacts on the skin. Various studies reported that there has been an increase in the number of patients referred to outpatient dermatology clinics with the complaint of variable hair diseases during the era of Covid-19. Hair seems to be substantially affected by both the infection itself and anxiety/stress provoked by the pandemic. Therefore, understanding the impact of Covid-19 on the clinical course of variable hair diseases has become a major concern in dermatology practice. To examine the frequency and types of various hair diseases, both new-onset and ingravescent, observed in healthcare providers. A web-based questionnaire related to the hair diseases seen in healthcare providers both prior to the Covid-19 pandemic and after the start of the pandemic was created. The type of both new-onset and pre-existing hair diseases and ongoing hair diseases observed during Covid-19 were investigated. A total number of 513 participants were included in the study. One hundred seventy cases were diagnosed with Covid-19. During the Covid-19 pandemic, 228 reported having at least one hair disease; the most common one being telogen effluvium, followed by hair greying and seborrheic dermatitis. There was a statistically significant relationship between the presence of a new-onset hair disease during the pandemic and being diagnosed with Covid-19 (p=0.004). Our study shows that Covid-19 infection has a significant impact on the emergence of new-onset hair diseases.

A rare case report: Werner syndrome

Abstract Introduction Werner syndrome (WS), also known as adult progeria, is a rare autosomal recessive syndrome caused by pathogenic loss of function of the WRN gene on chromosome 8p12. WS is characterized by signs of premature aging in young adults, including short stature, graying of hair, bilateral cataracts, and scleroderma-like skin changes. A thin, high-pitched voice is characteristic of patients. In addition, diabetes mellitus, cardiovascular disease and osteoporosis can also be seen at an increased rate. Patients have an increased thyroid neoplasms, malignant melanoma and meningioma. There is no specific or effective treatment for this rare syndrome. In this case, we aimed to present our patient with this rare syndrome. Clinical case A 28-year-old male patient was admitted for diabetes regulation and foot ulcers. In the patient's history, it was learned that he did not gain weight and did not gain sufficient height since the age of 14. He had been receiving insulin therapy for uncontrolled diabetes for about 10 years. He had cataract surgery at the age of 18. In our evaluation, there were scleroderma-like skin changes on the distal parts of both lower extremities. The patient's hair turned gray. His voice was high-pitched. Two of his siblings looked like him. One sibling who looked like him died at the age of 34. In the laboratory tests; FPG:306 mg/dL and HbA1C:11. The patient had hypergonadotropic hypogonadism. Rheumatological disease examination was normal. No pathological features were observed in lower extremity doppler examinations. Werner syndrome was considered in the patient who did not have sufficient height growth during adolescence, graying of the hair, a history of cataracts, scleroderma-like skin changes, and an elderly appearance. Malignancy scans of the patient were found to be normal. Genetic counseling was given to the patient and his family. The patient was taken to outpatient follow-up. Conclusion Werner syndrome is a rare disease. It is important to recognize patients in the early period, to prevent disease-related complications, especially in terms of the risk of malignancy development.

Tell me more – telomere biology and understanding telomere defects

Telomeres are DNA-protein structures at the ends of chromosomes that maintain chromosome stability and protects them from damage during mitosis and prevents abnormal fusion with adjacent chromosomes. They are non-coding repeats of the (TTAGGG)n nucleotide sequence. Telomere length affects cell replication potential and cell senescence. There are numerous proteins and enzymes that protect and maintain telomere length. Telomere disorders are a heterogenous group of diseases caused by germline pathogenic variants in genes involved in telomere maintenance. The clinical features are variable but often include bone marrow failure, idiopathic pulmonary fibrosis (IPF), liver cirrhosis, premature greying of hair, and dysplastic nails. However, incomplete penetrance and variable expressivity influence the clinical phenotype in individuals, which results is underdiagnosis or late diagnosis for many patients. At birth, telomere length on average in white blood cells (WBCs) is estimated to be 10Kb and the rate of attrition ranges from 27–41 base pairs each year. There are many factors that affect telomere length but genetics plays a significant role. Also, telomere length can vary in different cells in the same individual based on variable local gene expression. Idiopathic pulmonary fibrosis (IPF) is the most common telomere defect and approximately 30% of patients with sporadic or familial IPF have genetic defects in telomere-related genes. This talk will cover fundamental concepts of telomeres and discuss short and long telomere defects and measurement of telomere length in the clinical laboratory.

Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress.

Hair graying is a common and visible sign of aging resulting from decreased or absence of melanogenesis. Although it has been established that gray hair greatly impacts people's mental health and social life, there is no effective countermeasure other than hair dyes. It has long been thought that reversal of gray hair on a large scale is rare. However, a recent study reported that individual gray hair darkening is a common phenomenon, suggesting the possibility of large-scale reversal of gray hair. In this article, we summarize the regulation mechanism of melanogenesis and review existing cases of hair repigmentation caused by several factors, including monoclonal antibodies drugs, tyrosine kinase inhibitors (TKIs), immunomodulators, other drugs, micro-injury, and tumors, and speculate on the mechanisms behind them. This review offers some insights for further research into the modulation of melanogenesis and presents a novel perspective on the development of clinical therapies, with emphasis on topical treatments.

Prevalence of Premature Hair Greying, its Associated Factors and Impact on Quality of Life in Medical Students from Rajasthan, India

Background: Considering the paramount significance of hair in life, greying hair at a young age can be extremely distressing. In addition, an incompletely understood aetiology and scarcity of treatment options make premature hair greying (PHG) noteworthy. Aims: We aimed to estimate the prevalence of PHG in medical college students from Rajasthan, India, and any sociodemographic and lifestyle correlates of PHG and to determine its effect on the quality of life (QOL). Patients and Methods: A cross-sectional study was conducted amongst 295 students of a medical college in western Rajasthan, India, under the age of 25 years. A scalp examination was done to count grey hair. All factors were investigated using structured, pre-validated questionnaires. Results: The prevalence of premature greying of hair was 41.4%. Sociodemographic factors such as older age, rural residence and positive family history were significantly associated with PHG. The number of meals, fruit consumption and irregularity of meals were the lifestyle factors associated with PHG. The QoL of 54.1% of students with grey hair was poor; males and rural residents were more affected. Conclusions: Premature greying of hair is a fairly prevalent condition in medical college students affecting their QoL. Factors such as family history, age, residence and eating habits may predispose students to PHG.

Werner syndrome or adult progeria

Werner syndrome, a premature aging disorder, is a rare cause of pseudoscleroderma and can present with a multitude of clinical features involving the skin, endocrine and cardiovascular systems. Although genetic, the disease has its onset in puberty and cutaneous features like graying of hair, atrophic sclerotic skin, recurrent ulcers, and dyspigmentation are the first to manifest. All these features usually mislead the clinician to make a diagnosis of systemic sclerosis. A similar case is being presented and the importance of differentiating these two disorders is being discussed.

Role of Certain Plant Ingredients on Hair Disorders.

For maintaining healthy, attractive appearance hair has the vital role. Hair problems are common and can diminish self-esteem and selfconfidence of a person. Many forms of hair problems, baldness, alopecia, hair fall, gray hair, dryness, and most common dandruff require clinical care by a health care professional. Hair is sensitive to changes in the environment, diet, and overall health. Identifying these changes and resorting to the wisdom of Ayurveda for their coping mechanisms can help maintain good hair health. Ayurveda formulations always have attracted considerable attention because of their good activity and comparatively lesser side effects with synthetic drugs. This review gives knowledge regarding the beneficial effects and recent progress of medicinal plants for the treatment of hair disorders.

A brief overview on the concept of Palityaw.s.r. premature hair greying

Introduction: The traditional Indian medical system of Ayurveda employs the term Khalitya (~Hair fall) to describe hair loss, while the premature greying of hair is denoted by the term Palitya (~ Hair greying). Khalitya and Palitya are classified as Paitik (~dosha regulating body temperature and metabolic activities) disorders, which originate from the Dosha (~the regulatory functional factors of the body formed by the synchronized interplay between the five basic elements within any living system) known as Pitta. According to Ayurvedic principles, consistent disruption of the Pittadosha (~dosha regulating body temperature and metabolic activities), which represents the body’s heat and metabolism, may result in premature greying of hair. As per Ayurveda principles, the consumption of substances that enhance Pitta can lead to an aggravation of Pittadosha (~dosha regulating body temperature and metabolic activities), which is believed to be a contributing factor in the manifestation of grey hair. Materials and methods: Palitya (~premature greying of hair) information is gathered from many Ayurvedic and modern medical textbooks, magazines, journals, and the internet. It is a review paper with data gathered from all relevant sources. Result: All of the aforementioned formulations were acquired as a result of premature greying of hair. Discussion & Conclusion: Ayurveda has been identified as a viable alternative therapeutic approach for the condition of premature greying that was natural and harmless.

Product standardization of classically mentioned Hair dye and its In-vitro experimental study

There are large number of Palityahara Lepas (application-based solution for canities) mentioned in Ayurveda, however till date no published research work has been conducted which can prove effectiveness of these formulations. In fact, there is no pure ayurvedic formulation present in the market. Therefore, this study has been taken to analyse the effectiveness of one of the classically mentioned Palityahar Lepa – “Ayorajadi Lepa”. Total 45 samples were prepared with different permutations and combinations in the- form of ingredients and in method of preparation. In the efficacy study, samples prepared with 5 μm pure electrolytic iron and black mud, gave the best efficacy of a brown shade. Fermented sugarcane juice in place of fresh Juice, gives even better shade. As the most effective out of the 45 prepared formulation, also gives a considerable brown shade after 10 applications and there are a lot of hassles associated with the applications therefore this formulation at this stage, cannot be considered as a successful solution for grey hair.

Iconography of Buddhism: The Tradition of Depicting the Old White Man

The Old White Man is a local deity revered by Buddhists in Russia. His image, based on textual traditions and Buddhist iconography, prompted the name — the Old White Man, now widely accepted. In the written sources he is also known as the “Conqueror and subduer of the [master spirits] of earth and water”. The early images appeared in Mongolia under the influence of the Chinese traditional pictures of Tú Dì, ancient deities associated with localities, while later they were influenced by traditional images of Shòuxing, the deity of longevity. At an early stage of the iconographic tradition, the Old White Man is depicted as a priest or a high official; his functions are rendered via the characters of his companions, the host spirits of mountains (sabdaks) that have the features of man and animal or animals, such as a pair of deer, chained leopard (wolf), as well as ritual objects, including a carved staff or a dragon head staff. At a later stage, there may be symbols associated with the giver of longevity and fertility (bald phallic head, cave, and peach). The text of the “Sutra of the Old White Man” includes the description of his appearance (a white-bearded, bare-headed old man in a white robe), attributes (a dragon head staff) and an allegorical landscape of a mountain and fruit trees. Neither early nor recent Mongolian and Buryat pictures fully correspond to the description. Much closer to it is the Kalmyk iconographic tradition. The Old White Man’s image of the Kalmyk nomads goes back to the ancient mythological idea of the deity as the keeper of domestic animals. Due to transformations in the religious sphere, the keeper of domestic animals becomes the Old White Man, the lord of all living beings and all earthly space. Traditionally, he is presented as a standing old man, bare-headed and his long gray hair gathered in the form of a triratna. He is dressed in a belted robe, with another swinging robe thrown on it. In his right hand, he holds a staff with a dragon’s head and a rosary in his left. There are no companions or animals. The symbolic landscape serves to enhance the grandiose figure of the old man. The details of the attire and the landscape refer to the former Chinese influence.

Captcha-Based Honey Net Model against Malicious Codes

The rate of passive and active attacks has been on the increase lately affecting both individuals and institutions. Even when internal control procedures are in place, malicious codes from intruders into the network have left so much to be desired. As a result, many Chief Information Security Officers have grown grey hair because of their inability to effectively handle attacks from various ends. Various attempts and technologies have been made in the time past with a measure of success. Intrusion Detection Software (IDS), Intrusion Prevention Software, firewall, honey pots and honey nets have been deployed and with great respite from losses arising from cyber-attacks. Cyber security is the duty of everyone and all must see it as such. As tiers of government and law enforcement agents are doing their best, everybody must be seen to play their parts. Fraudsters have also not seemed to be tired of seeking vulnerabilities to exploit. Then, cyber security experts should not let off their guards but make efforts to harden their security. A way of doing is to intelligently provide a solution that has the capability of detecting and proactively hardening security. This paper proposes a honey net model that is captcha-based and capable of extracting details from hackers with a view to building a robust defense against black hat attackers. This research was able to prevent the botnet with the use of captcha and also redirect suspected traffic to the honeynet which was then captured for the purpose of improving the security of the network. The result showed that any bandwidth greater than the set threshold was not allowed to go into the network but redirected to honeynet where details were logged. Also, with a threshold of 100 mbs, inbound traffic of higher bandwidth such as 110 mbs and 150 mbs was denied access thereby giving 100% detection rate.

Repigmentation of gray hair: A case report with a brief review of literature

Repigmentation of gray hair: A case report with a brief review of literature

Generation of Pmel-dependent conditional and inducible Cre-driver mouse line for melanocytic-targeted gene manipulation.

Conditional and inducible gene targeting using Cre/loxP-mediated recombination is a powerful reverse genetics approach used to study spatiotemporal gene functions in specified cell types. To enable temporal gene manipulation in the melanocyte lineage, we established a novel inducible Cre-driver mouse line by targeting an all-in-one tetracycline/doxycycline (Dox)-inducible Cre expression cassette into the Pmel locus (PmelP2A-TetON3G-TRE3G-iCre ), a gene locus preferentially expressed in pigment cells. By crossing these Cre-driver mice with a strong Cre-reporter mouse line, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze , we show the effectiveness of the PmelP2A-TetON3G-TRE3G-iCre mouse line in facilitating Dox-inducible Cre/loxP recombination in a wide variety of pigment cell lineages including hair follicle melanocytes and their stem cells. Furthermore, to demonstrate proof of concept, we ablated Notch signaling postnatally in the PmelP2A-TetON3G-TRE3G-iCre mice. In agreement with the previously reported phenotype, induced ablation of Notch signaling in the melanocyte lineage resulted in premature hair graying, demonstrating the utility of the PmelP2A-TetON3G-TRE3G-iCre allele. Therefore, the PmelP2A-TetON3G-TRE3G-iCre mouse line is suitable for assessing gene functions in melanocytes using an in vivo inducible reverse genetics approach. Furthermore, we unexpectedly identified previously unrecognized PMEL-expressing cells in non-pigmentary organs in the mice, suggesting unanticipated functions of PMEL other than melanosome formation.

Palitya w.s.r to Premature Graying of Hair -An Ayurvedic Overview

Premature graying of hair is referred to as "Palitya" in the Ayurvedic method and falls under the general category of "Shiroroga."Palitya mainly shows Dosha’s imbalance of our body. This premature graying of hair refers to the graying of hair in young age or before the age of 35 years. In Ayurveda this is known as “Palitya”. Grey Hair is caused by gradual reduction of melanin production overtime in your hair follicles. Melanin a pigment that gives colour and smoothness to your hair. Eventually the hair begins to lose its colour. Ayurveda says, the “Bhrajaka Pitta a pigment responsible for imparting natural colour to our skin as well as to hair also seated in superficial layer of skin (Avabhasini). Soft, lustrous, silky, black hair are the sign of long healthy life span as per said by Acharya Charaka. In the present era sedentary life style, imbalanced diet, tense, mental conditions and polluted hair, water and food have led to lot of complications which are difficult to remove. Therefore global interest these days is developing towards Ayurveda to face the Challenge be it preventive aspect or curative treatment method of pacification, management of disease in its initial stage or final stage. To gather all information related to Palitya at one place which is availed in different Ayurvedic texts and for elucidation of this knowledge in a proper manner the present study has been undertaken.

An empirical study on the client’s perspective in decision making with regard to lawyer selection for trial courts: Does grey hair matter?

An empirical study on the client’s perspective in decision making with regard to lawyer selection for trial courts: Does grey hair matter?

A Biologically Inspired Hair Aging Model

Hair rendering has been a focal point of attention in computer graphics for the last couple of decades. However, there have been few contributions to the modeling and rendering of the natural hair aging phenomenon. We present a new technique that simulates the process of hair graying and hair thinning on digital models due to aging. Given a 3D human head model with hair, we first compute a segmentation of the head using K-means since hair aging occurs at different rates in distinct head parts. Hair graying is simulated according to recent biological knowledge on aging factors for hairs, and hair thinning decreases hair diameters linearly with time. Our system is biologically inspired, supports facial hair, both genders and many ethnicities, and is compatible with different lengths of hair strands. Our real-time results resemble real-life hair aging, accomplished by simulating the stochastic nature of the process and the gradual decrease of melanin.

A Pilot Study on Evaluation of Formulated Herbal Hair Oil

Hair follicles are surrounded by the dermis, but the cells are part of the epidermis and are separated from the dermis by the basal lamina layer. The main aim of the study is to design and evaluation of versatile Herbal Hair Oil to prevent and control hair-related problems. The main objectives of the study are Provides hair conditioning, Prevention & control of hair fall, Reduce scalp irritation, Prevents premature greying of hair, Treats Dandruff, Relieves all types of headaches especially migraine & Hangover headaches gives a shiny and glossy appearance.

Tricoscopia en la alopecia areata: descripción de 10 casos

IntroductionAlopecia areata is a non-scarring alopecia of the autoimmune type characterized by an abrupt arrest of the follicular cycle, which can affect any hairy area. The diagnosis is clinical and trichoscopic, the latter with a fundamental role not only in diagnosing the disease, but also in determining its evolutionary stage, assessing signs of activity, remission, or chronicity, which makes it a fundamental tool in follow-up of our patients. Materials and methodsThe study includes 10 patients diagnosed with alopecia areata (AA) based on clinical history, physical examination, and trichoscopic findings. All trichoscopic images were obtained using a x10 magnification handheld dermatoscope (DermLite DL4) and an attached cell phone that increased magnification to x15 (Iphone 12, apple). They were reviewed retrospectively, the elements identified in each case were highlighted and a descriptive statistical analysis was performed. ResultsThe following elements were observed: black dots (80%), yellow dots (60%), exclamation mark hair (60%), broken hairs (60%), pigtail or circular hairs (40%), gray hairs (40%), repopulation straight hairs (30%), tapered hairs (10%), Pohl-Pinkus constrictions (10%), and white dots (10%). ConclusionsBlack dots, exclamation mark hairs, and yellow dots were the most frequent findings in our series. Blackheads, broken hairs, and exclamation point hairs were positively correlated with active disease.

Cerebrolysin induces hair repigmentation associated to MART-1/Melan-A reactivation

Hair graying, a prototypical sign of human aging, is a progressive loss of pigmentation from growing hair shafts caused by disease and as a side effect of medications. Cerebrolysin is a neuropeptide preparation that mimics the effect of endogenous neurotrophic factors. Cerebrolysin has been widely used in neurologic conditions, such as cerebral stroke, Alzheimer’s disease, and dementia, among others. Cerebrolysin treatment has achieved to regain or maintain the cognitive ability of affected patients; however, up to date, there are no reports about the reactivation of hair pigmentation. We describe a previously not described effect occurring on patients receiving Cerebrolysin treatment for neurologic diseases and whether this effect is associated in reactivation of melanocytes and melanin expression. Here, we report five patients (mean age, 70.6 years), who also had age-related hair graying and scalp hair repigmentation during Cerebrolysin treatment. Macroscopic analysis revealed hair repigmentation consisted in diffuse darkening of the scalp hair. Impregnation and immunostaining analysis were performed on scalp biopsies taken before and after Cerebrolysin treatment; the results showed greater melanin and melanocyte marker MART-1/Melan-A staining following Cerebrolysin treatment. We present, to our knowledge, the first report on hair repigmentation is a previously not described effect occurring following Cerebrolysin treatment.

The Role of Lipids in the Process of Hair Ageing

An obvious sign of ageing is the loss of hair colour due to a decrease or lack of melanin in hair fibres. An examination of the lipid levels and structure of grey hair determined using µ–FTIR revealed a high correlation between the characteristics of lipids located in the cuticle and the water dynamics of the fibres. Therefore, a deep study based on external and internal lipid extraction, an analysis using thin layer chromatography coupled to an automated flame ionisation detector, calorimetric analyses and the physico-chemical evaluation of the delipidated fibres were performed. Hairs were evaluated to identify changes in the organisation of these lipids using Fourier transform infrared spectroscopy and their effect on the water dynamics of the fibres. The primary differences observed for the lipid extracts from white hair compared to brown hair were the lower amount of the internal lipids extracted, which were primarily composed of free fatty acids (FFAs) and ceramides, with a higher content of lower phase transition peaks, indicating increased unsaturated compounds that promote higher fluidity of the lipid bilayers. The virgin white fibres exhibited lower levels of embedded water, with lower binding energies and higher water diffusion, indicating higher permeability. The IR study confirmed the low lipid levels and the greater disorder of white hair. These results may be of interest for cosmetic treatments to which patients with grey hair may be subjected.