On panleikopenia, mostly non-vaccinated animals are sick before the age of 2 years, but most of the cats suffer from 1.5 to 6 months. It is established that for panleukopenia of cats typical sea- sonal flow. More often this disease is registered in the spring-summer-autumn period, but peak occurs in the summer. During the pathoanatomical study, the most distinct changes were recorded in the small intestine and lymphoid organs, due to the reproduction of the pathogen of infection. In all the dead animals, there were changes in the thymus. In most cases, the thymus is atrophied, a sharp decrease in the number and mag- nitude of the particles, a lack of division into cortical and brain substances. The spleen is slightly enlarged. Microscopically, there was a decrease in the number of lymphoid nodes, the absence of reactive centers in them, and the rarity of cellular elements. Lymph nodes are enlarged, hyperemic. Noticed swelling of the stroma, expansion of sinuses, dilution of cellular elements, proliferation of reticular cells. Specific signs for parvovirus infection of cats should be considered as well-defined inflammatory hyperemia of the serous membranes and thickening of the wall of the empty and iliac gut as a result of hemorrhagic jejuno-ileitis. Non-specific, but permanent clinical and morphological features of the disease are diarrhea and dehydration. In the external examination of the dead bodies of animals, there were dehydration and cachexia, loss of skin elasticity, dimness of the wool, dryness of the mucous membranes, subcutaneous tissue and skeletal muscles, and the inclination of the eyeballs into orbit. The death of animals for panleukopenia occurs as a result of hemorrhagic enteritis, and the direct cause of death is a reflex respiratory arrest as a result of pulmonary edema against the background of venous congestion in a small circle of blood circulation. Keywords: cats, panleukopenia, pathoanatomical section, macroscopic changes, diarrhea, dehydra- tion, hemorrhagic enteritis, posthumous diagnosis