Hematological Parameters In Patients Research Articles

Clinical significance of evaluation of some metabolic and hematological parameters in patients with sudden sensorineural hearing loss

BackgroundSudden sens orineural hearing loss (SSNHL) is a medical emergency, being mostly an idiopathic disease. Understanding the pathogenesis of SSNHL may help physicians for diagnosis and intervention.ObjectiveThe aim of the present study was to investigate some metabolic and hematological parameters in patients with SSNHL and related them to their clinical condition.Patients and methodsThe study was conducted on 50 patients with SSNHL and 20 age-matched and sex-matched controls. Both groups were subjected to audiological and laboratory evaluation of their fasting blood sugar (FBS), lipid profile, thyroid function test, neutrophil–lymphocyte ratio, and platelet–lymphocyte ratio. Moreover, the relation between these laboratory parameters and the severity of hearing loss was studied.ResultsBy comparing patients with parameters in both groups, FBS, triglycerides (TG), neutrophil–lymphocyte ratio, and platelet–lymphocyte ratio were found to be significantly increased in the patient group. Moreover, increased FBS, TG, and free thyroxine appeared to be related to the severity of the hearing loss.ConclusionHyperglycemia, hypertriglyceridemia, and hyper-inflammatory state can be considered as risk factors in the pathogenesis of SSNHL. Moreover, increased serum levels of FBS, TG, and free thyroxine are closely associated with the severity of the disease.

Study of Hematological Parameters in Patients with Scorpion Envenomation Presented to the Poison Control Center of Ain Shams University Hospitals

Study of Hematological Parameters in Patients with Scorpion Envenomation Presented to the Poison Control Center of Ain Shams University Hospitals

Clinical and Hematological profile of Paediatric Patients with Cleft Lip and Palate in a Tertiary Care Hospital of Haryana, India

Introduction: Cleft lip and/ or cleft palate are the most common visible craniofacial anomalies. These patients often have feeding difficulties and recurrent infections leading to an altered immune system which can be assessed by the variations in hematological parameters. We intended to assess the clinical profile and the hematological parameters in patients with cleft lip and palate. Methods: This is a three-year cross-sectional study conducted at SGT Medical College, Gurugram, Haryana, India from January 2017 to December 2019 involving assessment of patients with cleft lip and palate who visited the paediatric unit for complete evaluation before surgery. Syndromic children or those with associated deformities were excluded .A total of 115 patients were enrolled in the study and the following information was recorded: Age, Gender and type of cleft (Cleft lip and alveolus, cleft lip, alveolus and palate, and isolated cleft palate). Hematological parameters including hemoglobin, total leukocyte count, differential leukocyte count, absolute eosinophil count, and red cell indices were evaluated and compared amongst the anatomical subtypes. Results: A total of 115 patients were included in the study, of which 66 (57.4%) were males and 49 (42.6%) were females. 57 (49.6%) had a cleft lip, alveolus, and palate, 36 (31.3%) had a cleft lip and alveolus and 22 (19.1%) had cleft palate only. Anaemia was present in 71.1% of cases. 83.4% cases of cleft lip and alveolus while81.8% of isolated cleft palate were anaemic. Microcytic hypochromic anaemia was present in 63.4% of cases while 36.6% had normocytic normochromic anaemia. The total leukocyte count was elevated in 60 children (52.2%) which was highest in cleft lip and alveolus (66%). Absolute neutrophil count was significantly high in the lip and alveolus groups.(13.9%) Absolute lymphocyte count was highest in lip and alveolus (30.56%). Absolute monocyte count and the absolute eosinophil count was low in the majority of cases. Conclusions: A large number of children with cleft lip and/ or palate are not exclusively breastfed due to anatomical deficits. They need supplemental iron to meet the demands. A standard policy to provide auxillary iron by health care professionals should be made at the first visit to the health centre because nutritional anaemia negatively affects the physical and cognitive development of a child. It also unnecessarily prolongs the date for optimum and safe surgery.

POLİSİTEMİA VERA OLGULARINDA JAK2 V617F MUTASYON SIKLIĞI VE LABORATUVAR BULGULARI İLE İLİŞKİSİ

Amaç
 Polisitemia vera (PV) miyeloid hücrelerin klonal proliferasyonu
 ile karakterize klonal bir hastalıktır. Janus
 tirozin kinaz 2 (JAK2) geni V617F mutasyonunun hastalığın
 moleküler patogenezinin temelini oluşturduğu
 gösterilmiştir. Bu çalışmada PV’lı hastalarda JAK2
 V617F mutasyon sıklığı ve hematolojik parametreler
 ile arasındaki ilişkinin incelenmesi amaçlanmıştır.
 Gereç ve Yöntem
 Bu retrospektif kohort çalışmasına BCR-ABL negatif
 PV tanılı 18’i kadın, 60'ı erkek olmak üzere toplam 78
 hasta dahil edildi. Hastalara ait poliklinik dosyaları incelenerek
 demografik özellikler, laboratuvar bulguları
 ve JAK2 V617F mutasyon analiz sonuçları kaydedildi.
 JAK2 V617F mutasyon analizleri Real-Time PCR
 yöntemi ile yapıldı.
 Bulgular
 Çalışmaya dahil edilen 78 PV hastasının 21’inde
 (%26,9) JAK2 V617F mutasyonu saptandı. Mutasyon
 varlığı ve cinsiyet arasında fark saptanmadı (p>0.05).
 Mutasyon pozitifliğine göre yapılan gruplandırmada
 JAK2 V617F mutasyonu taşıyan hastalarda yaş, RBC,
 RDW ve PLT seviyeleri açısından anlamlı derecede
 yüksek saptanırken (sırasıyla, p=0,000; p=0,030;
 p=0,028; p=0,029), serum demir düzeyi açısından
 anlamlı derecede düşük saptandı (p=0,036) . WBC,
 HB ve HCT seviyeleri her iki grupta benzerdi (p>0,05).
 Sonuç
 Mutasyonun prognostik değerini ve klinik ve laboratuvar
 değişkenleriyle ilişkisini göstermek için daha kapsamlı
 prospektif çalışmalara ihtiyaç vardır.

Relationship between Fasting Blood Sugar and Some Haematological Parameters in Diabetic Patients Attending Nigerian Navy Reference Hospital Calabar, Cross River State, Nigeria

Background of Study: Diabetes mellitus is a clinical syndrome characterized by hyperglycemia due to absolute or relative deficiency of insulin. Lack of insulin, whether absolute or relative, affects the metabolism of carbohydrate, protein, fat, water and electrolytes (Sacks, 2013). Gestational Diabetes develops usually in the second or third trimester, as a result of hormones secreted by the placenta, which inhibit the action of insulin. A survey in Cross River State (CRS) gave a prevalence of Diabetes Mellitus (DM) at 6.5% in the age group 20 and above. This translates to an estimated 97,500 Diabetics within the population of 3 million.
 Aim of Study: This study evaluated fasting blood sugar and some haematological parameters in patients with diabetes mellitus visiting Nigeria Navy Reference Hospital Calabar, Cross River State, Nigeria.
 Materials and Methods: This cross sectional study evaluated a total of one hundred (100) subjects (males and females) comprising of diabetic and non-diabetic (controls) subjects using glucose oxidase peroxidase method, and sysmex KX-21N haematology CBC auto analyzer. Patients were aged between 20-55 years of age.
 Results: It showed that diabetes patients exhibited significant (p<0.05) decrease in the following parameters compared with the control group:Lymphocyte, Eosinophil and Platelets count. The Total White Blood Cells, Neutrophil, Monocyte, Basophil and FBS did not vary between the diabetes patients and the control group and only platelet established significant relationship in terms of age compared with other parameters. Based on the findings of the study, it can be concluded that there is a statistically significant increases (P<0.05) in platelet in the males compared with the females. Also, diabetic patients showed no significant in PCV and Hb value than the control subject.
 Conclusion: It is important that haematological profile should be included as a routine screening investigation to diagnose diabetic patient and treat accordingly. Full blood count as one of the routine laboratory tests is required in the management of diabetic patients.

A RETROSPECTIVE OBSERVATIONAL STUDY OF COMPARISON OF HEMATOLOGICAL PARAMETERS ALONG WITH THE EFFECT OF CHEMOTHERAPY AND RADIOTHERAPY IN DIFFERENT STAGES OF BREAST CANCER

Breast cancer is one of the top leading causes of death and most common malignancies among women all over the world. Chemotherapy and radiotherapy are the predominant treatment measures of cancer along with surgery. The current study aims to compare the hematological parameters in patients undergoing chemotherapy and radiotherapy in different stages of breast cancer. A decline in hematological parameters is most commonly seen trend in patients undergoing these treatments, which adversely influences the outcome of cancers. The study also evaluates the prevalence of thrombocytopenia, neutropenia and anemia in patients who received radiotherapy, chemotherapy and concurrent therapy. A total of 103 female breast cancer cases were collected in which 23 patients received radiotherapy, 44 patients received chemotherapy and 36 patients received concurrent therapy. The hematological parameters were found to be declined at different stages of cancer. The patients also showed decline in blood counts at each treatment, but all the parameters were declined in patients undergone concurrent therapy. Thus, this study helps to evaluate the requirement of complete blood count investigation before and during the therapy in order to assist the dosage adjustment and dietary modifications to minimize the risk of therapy related fatigue and infections and thus improving the efficacy of treatment outcome and health related quality of life of patients.

Efficacy of Avapritinib in Patients with Advanced Systemic Mastocytosis: Hematologic and Bone Marrow Responses from the Phase 2 Open-Label, Single-Arm, Pathfinder Study

Efficacy of Avapritinib in Patients with Advanced Systemic Mastocytosis: Hematologic and Bone Marrow Responses from the Phase 2 Open-Label, Single-Arm, Pathfinder Study

Accuracy of Signs, Symptoms, and Hematologic Parameters for the Diagnosis of Infectious Mononucleosis: A Systematic Review and Meta-Analysis.

The accuracy of individual symptoms, signs, and several easily obtainable hematologic parameters for diagnosing infectious mononucleosis (IM) still needs to be confirmed. Improving the diagnosis of IM based on the clinical findings could prompt physicians to identify better which patients need a diagnostic test for IM. This study performed a systematic review to determine the accuracy of symptoms, signs, and hematologic parameters in patients with suspected IM that used heterophile antibody test or viral capsid antigen tests as the reference standard. The PubMed database was searched for all relevant articles. Two reviewers reviewed all studies in parallel and assessed the quality of the selected studies using the quality assessment of diagnostic accuracy studies 2 (QUADAS-2) criteria. The pooled measures of diagnostic performance were calculated by bivariate meta-analysis for each clinical finding, which included sensitivity, specificity, likelihood ratios, the diagnostic odds ratios, and the area under the receiver operating characteristic curve. Seventeen studies were included in our final analysis. The prevalence of IM ranged from 2.1% to 80% among prospective cohort studies. The presence of splenomegaly (positive likelihood ratio [LR+], 2.39; 95% confidence interval [CI], 1.11-5.51), palatal petechiae (LR+, 1.32-11.40), posterior cervical lymphadenopathy (LR+, 3.16; 95% CI, 1.45-5.20), and axillary or inguinal cervical lymphadenopathy (LR+, 3.05; 95 CI, 1.85-4.70) were moderately useful for ruling in IM. The most helpful hematologic parameters for ruling in IM include lymphocytes greater than 4 × 109/L and greater than 40% to 50%, or atypical lymphocytes greater than 40%. A combination of lymphocytes greater than 50% and atypical lymphocytes greater than 10% (LR+, 50.40; 95% CI, 8.43-162) was also found to be helpful to rule in disease. Most of the clinical findings have limited diagnostic value in ruling out the disease when absent. Although most symptoms and signs were unhelpful, the likelihood of IM is appreciably increased by several examination findings. Hematologic parameters were more accurate than symptoms and signs. Since most clinical findings have limited diagnostic value in ruling out the disease, physicians should not rely on the absence of any individual symptom or clinical sign for ruling out IM.

Role of Favipiravir on the Hematologic parameters in patients with COVID-19 infection

Objective: Favipiravir is a novel, orally bioavailable, purine nucleoside analogue drug. Recent studies showed that it was related to faster viral clearance time and a significant improvement rate in chest imaging in patients with COVID-19. While the mechanism of action of Favipiravir is well characterized, there is insufficient data about its effects on haematological inflammatory parameters during COVID 19 infection.
 Material and Methods: This observational study included 92 patients with COVID-19 (50 of them were female) with mild to moderate disease who taken Favipiravir in the Pandemic Center at Giresun University School of Medicine from April 2020 to October 2020. Patients with severe COVID-19 infection were excluded from the study.
 Results: After the five days of Favipiravir administration, compared to before the treatment, it was observed that the neutrophil counts of the patients (before the treatment mean 5.97 109/L (5.1 - 6.84) and after treatment 4.82 109/L (4.29 - 5.35) p=0,039) and Neutrophil/lymphocyte ratio (NLR) markedly decreased (before the treatment mean 6.88 (5.33 - 8.42) and after treatment 4.67 (3.23 - 6.10) p=0,002), while the lymphocyte count increased and these alternations were statistically significant. Platelet count and MCV levels were slightly increased after the treatment also statistically significant (p<0.001, p=0.001). Although there was a significant decrease in CRP levels, no significant change was observed in other inflammatory markers (Ferritin, Sedimentation, Fibrinogen, D-Dimer, and Troponin). The overall mortality rate was 4%, with no deaths in ICU. 
 Conclusion: In our study; in addition to previous knowledge from recent studies; increasing in the platelet count and decreasing in CRP and MPV levels are remarkable findings. These data may guide in the follow-up of Favipiravir treatment and in determining the prognosis.

Some features of hematological parameters and production of cytokines regulating inflammation in allergic rhinitis

BACKGROUND: Allergic rhinitis is a common IgE-mediated disease. Multiple mechanisms are involved in the regulation of IgE synthesis, and cytokines produced by immune cells play an important role in this process. In addition, the study of the features of immunological reactivity in seasonal allergic rhinitis is of interest both for getting new data about the pathogenesis of the disease and optimization of the treatment.
 AIMS: This study aimed to determine the cytokine status and hematological parameters in patients with seasonal allergic rhinitis outside the exacerbation period.
 MATERIALS AND METHODS: This study included 43 adult patients with seasonal allergic rhinitis (remission stage) and compared them with 47 healthy individuals. Patients with perennial symptoms and/or sensitization to perennial allergens were excluded. Complete blood cell count and serum interleukin (IL)-4, IL-5, IL-6, IL-8, IL-10, IL-18, monocyte chemoattractant protein-1 (MCP-1), total immunoglobulin (Ig) E, and eosinophil cationic protein levels were measured.
 RESULTS: The remission stage in patients with seasonal allergic rhinitis is characterized by higher serum levels of total IgE and IL-8 compared with the healthy group. The normal serum total IgE level of patients with seasonal allergic rhinitis in remission is associated with activation of the monocytemacrophage link (increased serum levels of MCP-1, IL-6, IL-8, and absolute and relative numbers of monocytes). Increased serum total IgE level is associated with the predominant signs of the Th2 phenotype of the immune response (increased serum levels of IL-4 and IL-5).
 CONCLUSIONS: The immune reactivity of patients with natural remission of seasonal allergic rhinitis is characterized by Th2 phenotype features if the serum level of IgE is increased and features of activation of monocytemacrophage system if the level of IgE is normal.

Prediction of three-month readmission based on haematological parameters in patients with severe COPD exacerbation.

Approximately one-third of patients hospitalised for an exacerbation of chronic obstructive pulmonary disease (COPD) are readmitted to the hospital within 90 days. It is of interest to identify biomarkers that predict relapse in order to prevent readmission in these patients. In our prospective study of patients admitted for COPD exacerbation, we aimed to analyse whether routine haematological parameters can help predict the three-month readmission risk. 106 patients were included, of whom 23 were female (22%). The age (mean ± SD) was 73 ± 10 years, and the forced expiratory volume in 1 second (FEV1) was 44 ± 15%. The haematological parameters were obtained from the first blood test result during admission. The variables were as follows: red cell distribution width, mean platelet volume (MPV), platelet (PLT) count, neutrophil to lymphocyte ratio, PLT to lymphocyte ratio, MPV to PLT ratio, and eosinophil count. Patients were differentiated into two groups for each haematological parameter according to median value, and the percentage of readmissions in each of the groups was recorded. Twenty-five patients (24%) were readmitted to hospital within three months of discharge. Only the difference in low-MPV and high-MPV patients was significant (37% vs 10%, p = 0.001). The predictive capacity for three-month readmission measured by the area under the curve (AUC) did not show clinically applicable values; the best result was for MPV (AUC 0.64). In the remaining values, the AUC was between 0.52 and 0.55. Routine haematological parameters proposed as prognostic biomarkers in COPD obtained at the moment of hospital admission were not useful for predicting three-month readmission.

Evaluation of Hematological Parameters in Predicting Short-Term Mortality for COVID 19 Patients with Gastrointestinal Symptoms: A Case-Control Study

Introduction: Due to local and systemic pathological mechanisms, the laboratory parameters -especially hematological parameters of patients with gastrointestinal symptoms may differ from those without. We aimed to investigate the difference between the hematological parameters of COVID 19 patients with gastrointestinal symptoms and those without. 
 Material and methods: Our study was designed as a retrospective case-control study. The case group consisted of COVID 19 patients with confirmed gastrointestinal symptoms. The control group consisted of COVID 19 patients without gastrointestinal symptoms. The hematological parameters of the patients were compared statistically.
 Results: One hundred and thirty patients were included in the case group, and 130 patients were included in control group. There was no statistical difference between the groups in terms of white blood cell count, neutrophil count, lymphocyte count, platelet count, hemoglobin, hematocrit, mean platelet volume, mean corpuscular volume, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio (p values: 0.642, 0.987, 0.132, 0.835, 0.306, 0.430, 0.057, 0.735, 0.321, 0.031, respectively)
 Conclusion: There is no significant difference between the COVID 19 patients with gastrointestinal symptoms and those without in the terms of the hematological parameters.

Assessment of inflammation with hematological parameters in patients with migraine and tension-type headache: a prospective study from a tertiary care center.

Aim: To investigate the role of inflammatory markers in patients with an acute headache attack. Materials & methods: This prospective controlled observational study comprised 150 subjects (migraine with aura [MA]n=51, migraine without aura [MO] n=51, tension-type headachen=48, healthy controls n=80). White blood cells (WBCs), neutrophil, lymphocyteand platelet counts, mean platelet volume, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratiowere documented. Results: MA and MO constituted 14.2% of the admissions to the emergency department due to headaches. In addition, MA and MO had higher WBCand MO showed higher neutrophil count during the attacks than healthy control (p<0.05). Conclusion: Although inflammatory parameters, including WBC and neutrophil counts, were high in headache patients, neutrophil-to-lymphocyte ratio did not show a significant rise. Clinical trial registration: NCT04891848.

Assessment of haematological parameters in patients with OSMF

Background: Oral submucous fibrosis (OSMF) is an insidious disease affecting any part of the oral cavity and predominantly occurs among Indians. The present study was conducted to assess haematological parameters in patients with OSMF. Materials &amp; Methods: 46 patients of OSMF of both genders and 46 healthy control were selected. Five millilitres of fasting venous blood were obtained to calculate haemoglobin level using and Sahli's method and the ferrone system was used for serum iron levels measurement. The chemiluminescent microparticle intrinsic factor test was used to quantify vitamin B12 in human serum. Results: Group I had 26 males and 20 females and group II had 23 males and 23 females. The mean PCV (%) was 44.3 and 36.2, MCV (fl) was 87.4 and 70.2, MCH (g/dl) was 27.6 and 25.1, MCHC (g/dl) was 32.9 and 28.3, Hb (gm%) was 13.5 and 10.1, iron (mg/dl) was 120.4 and 46.8 and vitamin B12 (pg/Ml) was 426.2 and 226.8 in group II and group I respectively. The difference was significant (P&lt; 0.05). Conclusion: All haematological factors was greatly reduced in OSMF patients.

Evolution of Hematological Parameters in Patients Undergoing Orthognathic Surgery With a View to Hospital Discharge: A Prospective Study.

The length of hospital stays of patients undergoing orthognathic surgery depends on related local and systemic factors. Hematological changes resulting from orthognathic surgery, followed up in the postoperative period until hospital discharge, have neither yet been established for specific cases, nor for normal situations. This study aimed to describe the hemodynamic parameters of patients undergoing orthognathic surgery, considering a prediction of hospital discharge. A prospective analytical study was carried out on a sample of convenience for this purpose. The erythrogram, leukogram, and platelet count were assessed 24 and 72 hours after surgery and compared with preoperative values. Intraoperative volume loss was also assessed. Inferential statistical analyses were performed as analysis of variance or Friedman test, paired Wilcoxon test, Mann-Whitney test, and 2-tailed Spearman correlation. The red blood cell count (mean ± standard deviation [median]); (4.60 ± 0.24 [4.56]), hemoglobin (12.82 ± 1.03 [12.75]), hematocrit (39.51 ± 3.47 [39.60]), and red cell distribution with (32.60 ± 0.88 [33.05]) were higher preoperatively (P < 0.001). Mean corpuscular volume (83.87 ± 5.63 [83.10]), mean corpuscular hemoglobin (27.50 ± 1.47 [28.00]), leukocytes (6262.00 ± 1448.36 [6380.00]). The volume loss varied between 463.87 and 752.13 mL (608.00 ± 144.13 [630.00]). The results of the hematological evaluations corroborate the expectation of standard discharge from the hospital, with reflected changes resulting from volume loss and intense postoperative inflammatory response, even under the anti-inflammatory pharmacological effect.

Dynamics of hematological parameters in patients with asymptomatic and mild course of COVID19 infection

We studied changes in the parameters of the general (clinical) blood test in dynamics in outpatient patients with an asymptomatic course and a mild degree of severity of COVID-19. The study involved 67 patients. 30 men and 37 women were examined, their average age was 35 years. All the interviewed patients did not take specific antiviral drugs. Clinical manifestations were evaluated at the time of the survey on the 1st and 7th day from the day of receiving a positive PCR result. The parameters of the general (clinical) blood test were determined by flow cytometry in the CBC + 5Diff mode on a Unicel® DxH 800 hematological analyzer (Beckman Coulter, USA) in dynamics on the 1st and 7th days of observation. The features of clinical manifestations in patients with an asymptomatic course and mild severity coincided with the data of other authors. Hematological changes were mainly characterized by changes in the number of white blood cells and their subpopulations. On the 7th day of observation, there was a significant tendency to increase the number of white blood cells, lymphocytes, eosinophils, neutrophils and platelets within the reference intervals.

Comparison of Selected Immune and Hematological Parameters and Their Impact on Survival in Patients with HPV-Related and HPV-Unrelated Oropharyngeal Cancer.

Simple SummaryThis is a research article on oropharyngeal cancer (OPC). The aim of the study was to assess and compare basic immune parameters and ratios in patients with Human Papilloma Virus (HPV)+ and HPV− OPC, before and after radiotherapy (RT) or chemoradiotherapy (CRT), and to investigate their impact on overall survival (OS) and disease-free survival (DFS). The higher neutrophil-lymphocyte ratio (NLR) and systemic immune inflammation (SII) are significant adverse prognostic factors for HPV+ OPC patients, because they are significantly associated with both inferior OS and DFS in this group, whereas the higher platelet cells (PLT) count is significant adverse prognostic factor for HPV− OPC patients, because it is significantly associated with inferior OS and DFS in this group. This study confirmed that determination of HPV etiology as well as analysis of various hematological and immune parameters should be a standard management in OPC patients in order to properly treat them for improved prognosis.Several immune and hematological parameters are associated with survival in patients with oropharyngeal cancer (OPC). The aim of the study was to analyze selected immune and hematological parameters of patients with HPV-related (HPV+) and HPV-unrelated (HPV−) OPC, before and after radiotherapy/chemoradiotherapy (RT/CRT) and to assess the impact of these parameters on survival. One hundred twenty seven patients with HPV+ and HPV− OPC, treated with RT alone or concurrent chemoradiotherapy (CRT), were included. Patients were divided according to HPV status. Confirmation of HPV etiology was obtained from FFPE (Formalin-Fixed, Paraffin-Embedded) tissue samples and/or extracellular circulating HPV DNA was determined. The pre-treatment and post-treatment laboratory blood parameters were compared in both groups. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), and systemic immune inflammation (SII) index were calculated. The impact of these parameters on overall (OS) and disease-free (DFS) survival was analyzed. In HPV+ patients, a high pre-treatment white blood cells (WBC) count (>8.33 /mm3), NLR (>2.13), SII (>448.60) significantly correlated with reduced OS, whereas high NLR (>2.29), SII (>462.58) significantly correlated with reduced DFS. A higher pre-treatment NLR and SII were significant poor prognostic factors for both OS and DFS in the HPV+ group. These associations were not apparent in HPV− patients. There are different pre-treatment and post-treatment immune and hematological prognostic factors for OS and DFS in HPV+ and HPV− patients. The immune ratios could be considered valuable biomarkers for risk stratification and differentiation for HPV− and HPV+ OPC patients.

Features of Hematological and Hemostasiological Parameters in Coronavirus Infection COVID-19 and Community-Acquired Pneumonia

Against the background of priority attention paid to the COVID-19 pandemic, there are also cases of community-acquired pneumonia of a different genesis. Identification of the features of lung lesions in such diseases is relevant during the spread of seasonal respiratory infections. The comparative study of the dynamics of hematological and hemostasiological parameters of blood in patients with pneumonia of various origins is of interest in terms of searching for predictors of the prognosis of the diseases development.Aim. To compare the features of clinical symptoms, hematological and hemostasiological parameters in patients with pneumonia caused by COVID-19 and in patients with community-acquired pneumonia.Materials and methods. During cross-sectional study two groups were formed: group 1 consisted of 92 patients diagnosed with moderate community-acquired pneumonia caused by COVID-19 infection; group 2 included 40 patients diagnosed with moderate community-acquired bilateral polysegmental pneumonia.Results. It was found that patients with COVID-19 had an older age (69 vs 39.3 years), a lower body temperature at admission (37.5 vs 38.85 °C), a lower percentage of reduced oxygen saturation (less than 89 % in 5.4 % of cases vs 10 % of cases). In most cases, the average values of some hematological parameters in patients with COVID-19 did not go beyond the reference range. Leukopenia (below 4 × 109 cells/l) and lymphopenia (below 1.1 × 109 cells/l) were observed in 26 % and 38 % of cases respectively; thrombocytopenia (less than 100 × 109 cells/l) – in 12.2 % of cases; hyperfibrinogenemia (more than 4 g/l) – in 65.3 % of cases. A direct correlation was found between platelet levels and leukocytes (R = 0.53; p &lt; 0.001) and lymphocytes (R = 0.29; p = 0.06). Compared with the patients of the group 2,on average, patients with COVID-19 had significantly lower levels of leukocytes and lymphocytes (2.5 times each; p &lt; 0.001) and an increased level of fibrinogen (by 45 %; p &lt; 0.001).Conclusion. In patients with pneumonia caused by COVID-19, we revealed the particular features of clinical symptoms, hematological and hemostasiological blood parameters compared to community-acquired nonspecific pneumonia.

A study of hematological parameters in patients with COVID-19 infection at a tertiary care centre

Background: The corona virus disease 2019 is caused by the virus SARS-CoV-2 and is declared as a global pandemic by World Health Organization. Alterations in various hematological parameters have been recently documented in the world literature in SARS-Cov-2 infection. However, still there is paucity of hematological data in these patients. Hence this study is an attempt to evaluate the pattern of the hematological parameters in COVID-19 patients in the Indian population in our region. The objective of the study is to see the pattern of alteration in hematological parameters with emphasis on total leukocyte count, absolute lymphocyte count and platelet count in COVID 19 positive patients.Materials and Methods: This is an observational study in 50 patients with laboratory-confirmed COVID-19 status admitted to G.K. General Hospital &amp; Gujarat Adani Institute of Medical Sciences, Bhuj, from 1st April 2020 to 30th June 2020. Statistical analysis of the data was carried out, and relevant findings were presented.Results: Among the 50 patients, there were 35 (70%) males and 15 (30%) females with an age range from 6 months to 82 years with twenty-five patients above 50 years. There was lymphopenia in 18 patients (36%), leukopenia in 2 patients (4%) and thrombocytopenia in 8 (16%) patients.Conclusions: Majority of the patients were elderly, and there was a male predominance. There was moderate to severe lymphopenia and mild thrombocytopenia.

Evaluating hematological parameters in women with endometriosis

In the present study, we aimed to evaluate the relationship between the level of hematological parameters and the presence and stage of endometriosis. We included medical records of patients diagnosed with endometriosis (endometriosis group) and patients diagnosed with benign non-endometriotic ovarian masses (control group), who were eligible based on inclusion and exclusion criteria and compared the preoperative level of hematological parameters between the two groups. According to our findings, neutrophil and WBC counts, mean platelet volume, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were significantly higher, and the haemoglobin concentration, platelet count, and absolute lymphocyte count were lower in women diagnosed with endometriosis compared to the control group. There was no significant difference in hematological parameters of patients with endometriosis stages III and IV. Finally, we found that the preoperative level of hematological parameters lacked sufficient power for the diagnosis of endometriosis. Also, our results indicate that endometriosis is associated with an inflammatory processes. IMPACT STATEMENT What is already known on this subject? Inflammatory factors are believed to be involved in the pathogenesis of endometriosis; however, there are inconsistent reports on the association between blood inflammatory markers and endometriosis. What do the results of this study add? The results of this study indicate that endometriosis is associated with inflammatory processes that lead to changes in hematological parameters; however, preoperative measurement of these parameters has not sufficient power for the diagnosis of endometriosis. What are the implications of these findings for clinical practice and/or further research? The preoperative level of hematological parameters lacks sufficient power for the diagnosis of endometriosis, but they may help doctors make a diagnosis in the clinical setting as auxiliary findings.