Assessment of haematological parameters in patients with OSMF

Abstract

Background: Oral submucous fibrosis (OSMF) is an insidious disease affecting any part of the oral cavity and predominantly occurs among Indians. The present study was conducted to assess haematological parameters in patients with OSMF. Materials & Methods: 46 patients of OSMF of both genders and 46 healthy control were selected. Five millilitres of fasting venous blood were obtained to calculate haemoglobin level using and Sahli's method and the ferrone system was used for serum iron levels measurement. The chemiluminescent microparticle intrinsic factor test was used to quantify vitamin B12 in human serum. Results: Group I had 26 males and 20 females and group II had 23 males and 23 females. The mean PCV (%) was 44.3 and 36.2, MCV (fl) was 87.4 and 70.2, MCH (g/dl) was 27.6 and 25.1, MCHC (g/dl) was 32.9 and 28.3, Hb (gm%) was 13.5 and 10.1, iron (mg/dl) was 120.4 and 46.8 and vitamin B12 (pg/Ml) was 426.2 and 226.8 in group II and group I respectively. The difference was significant (P< 0.05). Conclusion: All haematological factors was greatly reduced in OSMF patients.