ObjectiveMidwives are instrumental in improving maternal/newborn health outcomes. Since complications after childbirth are leading causes of maternal deaths, midwives’ knowledge of how to manage complications and care for the newborn is important. This study assessed midwives’ knowledge of immediate newborn care and management of postpartum complications. DesignA cross-sectional descriptive survey design was used. SettingFour hospitals that provide inpatient maternity services in Tamale, Ghana. Participants245 midwives who worked in the four hospitals. MeasurementsData were collected in December 2018 using an electronic survey questionnaire by the Johns Hopkins Program for International Education in Gynecology and Obstetrics, and analyzed using descriptive, bivariate, and multivariate statistics. FindingsAbout 98% of midwives were female. The mean age of midwives was 31.87 years. The percentage of midwives who responded correctly to questions on newborn care and management of postpartum complications ranged from 29.80% to 89.39%, and 32.17% to 91.43% respectively. Midwives were most knowledgeable about breastfeeding and immediate hemorrhage intervention, and least knowledgeable about cord care, thermal protection, newborn resuscitation, contraindications for vacuum extraction, treating metritis, and performing a cervical repair. Years of experience and age are predictive factors of midwives’ knowledge. Conclusion/ImplicationsThere remains the opportunity for continuing education on complication management. Additional training of midwives on newborn resuscitation is recommended.