A state-constrained guidance and control law is vital to the flight safety of an aerial interceptor against a maneuvering target. Taking the flight angle limitations, manipulation saturation, and terminal constraints into consideration, a novel integrated guidance and control (IGC) schema with a self-adjusting prescribed performance is proposed. To avoid the feasibility condition via the conventional barrier Lyapunov function-based method, a new state-dependent nonlinear mapping function is designed, based on which the state-constrained IGC system is converted into a constrained-free model. A novel prescribed performance with a self-tuning mechanism is proposed to guarantee satisfied transit and steady guidance performances. The backstepping technique combined with super-twisting integral sliding modes and newly defined predefined-time disturbance observers is implemented to generate state-constrained virtual command signals. All the signals in the closed-loop system are strictly proven to be bounded by Lyapunov stability theory. The simulation results show the effectiveness of the proposed IGC schema.