This study aims to develop efficient management strategies and assess the spatiotemporal dynamics of land use and land cover (LULC) on surface runoff modeling response dynamics for the long-term sustainability of watersheds. The soil and water assessment tool (SWAT) model was used to evaluate the LULC dynamics on GRSR in the Mae Wong Watershed (MWW) of Thailand. Using Landsat images, three different LULC maps (2011, 2021, and 2031) were created using the cellular automata markov chain (CA-Markov) model, and TerrSet 2020 geospatial monitoring and modeling software. In the overall MWW, the forestland has undergone deforestation and decreased by 2.10% of the total area and 2.72% of the total area has been transformed into agricultural lands due to human activity and population growth. The soil, LULC, weather, and the digital elevation model (DEM) were all used in the SWAT simulation procedure. To understand the groundwater recharge and surface runoff (GRSR) responses of each hydrologic response units (HRUs), the SWAT model was calibrated and verified using streamflow and the sequential uncertainty fitting (SUFI-2) technique from the SWAT calibration and uncertainty program (SWAT-CUP). The results indicate that there is a good agreement for both the calibration and validation phases of all LULC simulations. The study indicated that groundwater recharge has decreased over the last two decades while surface runoff has increased due to the forest area being converted to agricultural land. Thus, the study can support maximizing water management and strategies for systematically attaining sustainability.