Since proclaiming independence in 1960, Senegal has faced economic and demographic imbalances across its regions. To address these disparities, the government launched decentralization policies in three major phases, aiming to stimulate socio-economic growth at the local level. This study examines the impact of these policies on urban–rural development using socio-economic data between 2000 and 2020, and a multiple linear regression model in the entirety of Senegal. The findings reveal significant correlations between rural population growth, access to electricity, fertilizer availability, and per capita cultivated land, all positively associated with agricultural productivity. Additionally, rapid urbanization (47.3%) and weak land tenure (88.6%) adversely affect ecological systems and contribute to the proliferation of slums. A notable lack of health facilities per capita highlights a severe gap in healthcare accessibility. The study suggests increasing agricultural income, creating jobs, and promoting policies that support rural collective entrepreneurship as critical steps. It also recommends adopting a “one ecological zone, one economic activity” strategy to reduce economic disparities and encourage sustainable development in rural Senegal.