Research Group Research Articles

Organizing planning knowledge for automated vehicles and intelligent transportation systems

AbstractIntelligent Transportation Systems (ITS) are crucial for developing fully automated vehicles. While significant progress has been made with advanced driver assistance systems and automation technology, challenges remain, such as improving traffic information, enhancing planning and control systems, and developing better decision‐making capabilities. Despite these hurdles, the potential benefits of ITS are so many that its challenges have attracted substantial industrial investment and research groups interested in the automated driving field. In this work, a methodology based on state space search for planning knowledge integration is proposed. The main goal of the proposal is to provide a planning system with the necessary information to perform properly any task related to lateral and longitudinal control, path following, trajectory generation, arbitration and behavior execution by localizing the vehicle with respect to a high‐level road plan. To this end, this research compares cutting‐edge methods for rapidly finding the K nearest neighbor in relatively high dimensional road plans constructed from the traffic information stored in a high definition map. During the experimentation phase, promising real‐time results have been obtained for fast KNN algorithms, leading to a robust tree index‐based methodology for decision making in self‐driving vehicles combining path planning, trajectory tracking, trajectory creation, knowledge aggregation and precise vehicle control.

Arterial stiffness as a novel tool for the early prediction of preeclampsia: a perspective.

Preeclampsia is a leading complication of pregnancy that lacks accurate tools for its early prediction. Improved risk stratification tools early in pregnancy would enable more efficient allocation of limited healthcare resources while ensuring that pregnant women destined to develop preeclampsia receive appropriate care. This brief perspective highlights the current state of first-trimester preeclampsia prediction. We focus on arterial stiffness, an important hemodynamic indicator of vascular health that has shown promising results for improved early prediction of preeclampsia by our and independent research groups. Further, we outline the promise, applicability, and feasibility of integrating arterial stiffness assessments into clinical practice.

Charting the Research Status for Bamboo Resources and Bamboo as a Sustainable Plastic Alternative: A Bibliometric Review

With the increasing pollution caused by plastic products, people’s awareness of environmental protection has gradually increased. Based on the advantages of China’s bamboo resources and bamboo industry, the International Network for Bamboo and Rattan launched the ‘Utilizing bamboo as a sustainable alternative to plastic’ initiative in November 2022 to accelerate the implementation of the United Nations 2030 Agenda for Sustainable Development. This initiative provides a nature-based solution for global sustainable development, which will have a profound impact on promoting global green development, industrial science and technology, social services, cultural exchanges, and other fields. It has a huge market capacity and application potential. This study aims to understand the research status, hotspots, development trends, and prospects of this initiative. WoS and China National Knowledge Infrastructure (CNKI) were searched for the relevant literature on ‘utilizing bamboo as a sustainable alternative to plastic bamboo as plastic’ and ‘bamboo resources’ from the establishment of the database to 2024. Bibliometric methods and VOSviewer were used to analyze 1855 literatures with the above two keywords published in the Web of Science core set database from 2000 to 2024. A visual analysis was performed on the number of publications, national research institutions, researchers, number of citations, and research topics of the literature. For example, China, the United States, and India ranked in the top three in terms of the number of articles published, with 1103, 267, and 167, respectively. China had the highest number of citations, reaching 26,607. At the same time, the literature with ‘bamboo’ as the keyword in CNKI was analyzed to understand the species of bamboo currently studied. A literature investigation was carried out around the resource cultivation of the bamboo industry in our country, and it was found that the research on ‘use bamboo as plastic’ and ‘bamboo resources’ had been valued by scholars at home and abroad, and had formed a relatively stable research group. Using scientific and technological innovation to improve the product quality of ‘bamboo instead of plastic’, expanding its application scope and market demand, and realizeing the sustainable industry development of ‘bamboo instead of plastic’ is the current research hotspot and the future development direction.

How to Promote Climate Change Education: Based on the Study of the “Climate Change Education” Research Group

How to Promote Climate Change Education: Based on the Study of the “Climate Change Education” Research Group

Research on the connection performance and micro-hydration mechanism of super-performance grouting material for prefabricated component connections

Abstract The performance of grouting material determines the connection reliability of prefabricated components and the overall safety of the structure. In order to realize the rapid connection of prefabricated components, improve the construction efficiency and improve the quality of component connection. The research group has developed a grouting material with fast early strength improvement and high late strength. The formation mechanism was analyzed by scanning electron microscopy. The reliability of grouting material was verified by uniaxial tensile test of sleeve grouting connector. The results show that : CH, AFt and C-S-H are formed inside the grouting material, and the cementing system is dense inside. The skeleton formed by AFt inhibits the shrinkage of the system, which can provide support for the later compressive and flexural strength. Uniaxial tensile test results and theoretical analysis. The external reinforcement of the sleeve is broken, and the bonding performance between the grouting material and the reinforcement inside the sleeve is reliable. The internal bond stress is far less than the failure stress of the connector, which is about 50 % of the failure stress.

Development and in vitro characterization of new carnosine-loaded liposomal formulations.

Carnosine is an endogenous dipeptide characterized by a multimodal mechanism of action. However, its clinical potential is limited by serum and cytosolic carnosinases, which significantly reduce its bioavailability. Based on that, different research groups have worked on the development of new strategies able not only to prevent its rapid metabolization but also to improve its distribution and specific targeting. In the present study, the development and in vitro characterization of new liposomal formulations loaded with carnosine are described. Nanoliposomes, produced through Thin-Layer Hydration followed by Extrusion method, were first investigated for their physicochemical stability. Photon correlation spectroscopy and electrophoretic light scattering, assessing the stability of the formulations, showed a strong homogeneity-oriented tendency for up to two months. Particle size, polydispersity index, and zeta potential were determined through dynamic light scattering and electrophoretic light scattering, demonstrating an almost neutral charge of the formulation and an effective encapsulation of carnosine. The morphology assessment performed via scanning electron microscopy showed good conformity and polydispersity. Differential scanning calorimetry measurements suggest the ability of carnosine to stabilize the large unilamellar vesicles. Lastly, the newly developed carnosine-loaded liposomal formulations also showed a good safety profile in human microglia.

Cognitive function characteristics and influencing factors in patients with depressive disorders: a 5-year follow-up report based on the epidemiological survey of mental disorders in Shandong Province, China.

Cognitive impairment represents a notable feature of depressive disorders. Comprehending its characteristics and influencing factors is vital for patient rehabilitation. This study is based on the 2015 Shandong Province epidemiological survey of mental disorders, from which 871 individuals meeting DSM-IV criteria for depressive disorders were selected as the research group. Using 1:1:1 matching by sex, age, and residence, we randomly selected 825 individuals with no DSM-IV diagnosis but positive on GHQ-12 and additional risk assessments as the elevated risk control group, and 825 with negative screenings as the minimal risk control group. In 2020, a follow-up survey was conducted, resulting in a final analysis of 1,855 cases. The survey included demographic data, various clinical information, and a series of screening and questionnaire assessments. The current depressive group scored lower on the MoCA than the non-depressive group (t=8.86, P<0.01). The research group scored lower on the MoCA than the elevated and minimal risk group (F=11.98, P<0.01). The depression-unremitted group scored lower than the depression-remitted group (t=6.44, P<0.01). The Analysis indicated that males, with better life quality, poor early psychological status and, and longer education were associated with higher MoCA scores. Conversely, older age, rural residency, employment, current depression, and poor marital were associated with lower MoCA scores. Individuals with depression commonly suffer cognitive impairment, which tends to partially improve as depression remits. Individual cognitive function is influenced by early psychological health, depressive status, quality of life, age, sex, educational level, residence, occupational, and marital status.

From Fringe to the Mainstream: How ETD MS Brought O-GlcNAc to the Masses

O-GlcNAcylation was identified in the 1980s by Torres and Hart (1) and modifies thousands of cellular proteins, yet the regulatory role of O-GlcNAc is still poorly understood compared to the abundance of mechanistic information known for other cycling post-translational modifications like phosphorylation. Many challenges are associated with studying O-GlcNAcylation and are tied to the technical hurdles with analysis by mass spectrometry. Over the years, many research groups have developed important methods to study O-GlcNAcylation revealing its role in the cell, and this perspective aims to review the challenges and innovations around O-GlcNAc research and chronicle the work by Donald F. Hunt and his laboratory, particularly in development of ETD and its application to this field of research.

Breaking the Loop: A Meta‐Analysis on the Bidirectional Effects of Materialism on Social Well‐Being Outlining Future Research Directions

ABSTRACTThis meta‐analysis examines correlational and experimental research linking materialism—broadly understood as an excessive focus on acquiring wealth and possessions that convey status—and social well‐being—characterised by healthy interpersonal relationships and a sense of social support and integration. We identified 55 reports containing 72 independent studies and 123 effect sizes (N = 44,376). Meta‐analytic calculations yielded a pooled effect of r = −0.18, suggesting that the effects of materialism on social well‐being (e.g., loneliness or relationship satisfaction) may be greater than the effects of materialism on individual well‐being (e.g., self‐esteem or life satisfaction). Moderation analyses revealed that the effects are bi‐directional, consistent across genders and cultures and significantly stronger in children and adolescents. These findings emphasise the universal and reciprocal link between materialism and social well‐being and highlight the particular vulnerability of younger populations. Based on the results, we propose suggestions for further research to address the existing gaps and strengthen the current evidence, and recommend a sample size of 240 participants for correlational studies and 50 participants per group for experimental research. This work calls for targeted interventions and policies to tackle the adverse social effects of materialism, particularly among young populations.

Lead Slowing-Down Neutron Spectrometry II: Cross-Section Data for &lt;sup&gt;243&lt;/sup&gt;Cm(&lt;i&gt;n&lt;/i&gt;, &lt;i&gt;f&lt;/i&gt;), &lt;sup&gt;244&lt;/sup&gt;Cm(&lt;i&gt;n&lt;/i&gt;, &lt;i&gt;f&lt;/i&gt;), &lt;sup&gt;245&lt;/sup&gt;Cm(&lt;i&gt;n&lt;/i&gt;, &lt;i&gt;f&lt;/i&gt;), &lt;sup&gt;246&lt;/sup&gt;Cm(&lt;i&gt;n&lt;/i&gt;, &lt;i&gt;f&lt;/i&gt;), &lt;sup&gt;247&lt;/sup&gt;Cm(&lt;i&gt;n&lt;/i&gt;, &lt;i&gt;f&lt;/i&gt;), &lt;sup&gt;248&lt;/sup&gt;Cm(&lt;i&gt;n&lt;/i&gt;, &lt;i&gt;f&lt;/i&gt;) at Energies up to 100 keV

The possibilities of lead slowing-down neutron spectrometry have been demonstrated. We present a review of the results of a series of works on measuring the fission cross-sections of curium isotopes 243Cm, 244Cm, 245Cm, 246Cm, 247Cm, 248Cm by neutrons with energies below 100 keV, performed by a joint group of researchers of INR RAS and SSC RF IPPE on the SVZ-100 neutron spectrometer. This third-generation spectrometer has a high luminosity, which made it possible to study neutron-nuclear processes in microgram samples of radioactive nuclides, which is not available in experiments using time-of-flight spectrometry. The results of work at the INR RAS–SSC RF IPPE are reflected in international nuclear databases, complement the known experimental data and in some cases indicate the need to adjust the recommended values.

EXPERIENCE OF CLINICAL AND RADIOGRAPHIC CORRELATION IN PATIENTS WITH PAIN SYNDROME OF TMJ DYSFUNCTION IN ATRICULATION-OCCLUSIVE DISORDERS

This article examines the imaging anatomy of the temporomandibular joint (TMJ), describes the technique of calculating the gaps between the fossa and the head, their comparison based on TMJ computed tomography (CT) data, and their comparison with clinical signs of TMJ dysfunction. The aim was to determine CT diagnostic criteria for persistent functional displacement of the lower jaw in patients with TMJ functional disorders in occlusal-articulation disorders at the stage of orthopedic treatment planning. Research materials and methods. A clinical and radiological examination of 150 patients with functional disorders of the masticatory apparatus and occlusal disorders, who were included in the experimental group, and 30 practically healthy persons – the control group, was carried out. The results. The presence of a pain syndrome was primarily determined - 60 patients (40.00%) complained of pain in the TMJ area, masticatory muscles or headache, and in 19 (31.67%) of them, complaints of pain bothered more than half year TMJ pain was found in 30 (20.00%) patients, in masticatory muscles in 43 (28.67%), headache in 47 (31.33%). Hypertonus of the masticatory muscles was established - 94 - 62.67% with their hypertrophy - 46 - 30.67%, both unilateral and bilateral, which were observed simultaneously with the parafunction of the masticatory muscles (34 - 22.67%). Palpatory functional stable displacement of the lower jaw was determined in 135 (90.00%) patients of the research group, in 57 (42.22%) of them significant pain syndrome was present in 46 (80.70%). At the same time, deviation or deflexion was established in 74 (49.33%) patients of the experimental group, restriction of mouth opening in 52 (32.67%) patients; crunching and clicking in the TMJ - 112- 74.67%. The presence of bilateral posterior displacement of the heads of the lower jaw was established in 103 (68.67%) patients with TMJ dysfunction, of which 42 (40.77%) came to the doctor with complaints of orofacial pain, and in 22 (14.67%) significant displacement, 17 (77.27%) of them had a pain syndrome; unilateral posterior displacement of the heads of the lower jaw in 32 (21.33%) patients with TMJ dysfunction, 16 (50.00%) of them have a pain syndrome, and 11 of them have a significant displacement; in 16 (10.67%) one-sided posterior displacement with simultaneous anterior displacement in the contralateral joint was established with a subjective assessment of the absence of pain syndrome. Presence of a significant displacement in at least one joint was established in 72 (48.00%) patients with TMJ dysfunction, 63 (87.50%) of them had a pain syndrome. Conclusions. CT enables a comprehensive assessment of bone structures and their connection in the TMJ and is a valuable tool for planning orthopedic treatment and evaluating its effectiveness in dynamics.

Back to the future - 20 years of progress and developments in photonic microscopy and biological imaging.

In 2023, the ImaBio consortium (imabio-cnrs.fr), an interdisciplinary life microscopy research group at the Centre National de la Recherche Scientifique, celebrated its 20th anniversary. ImaBio contributes to the biological imaging community through organization of MiFoBio conferences, which are interdisciplinary conferences featuring lectures and hands-on workshops that attract specialists from around the world. MiFoBio conferences provide the community with an opportunity to reflect on the evolution of the field, and the 2023 event offered retrospective talks discussing the past 20 years of topics in microscopy, including imaging of multicellular assemblies, image analysis, quantification of molecular motions and interactions within cells, advancements in fluorescent labels, and laser technology for multiphoton and label-free imaging of thick biological samples. In this Perspective, we compile summaries of these presentations overviewing 20 years of advancements in a specific area of microscopy, each of which concludes with a brief look towards the future. The full presentations are available on the ImaBio YouTube channel (youtube.com/@gdrimabio5724).

Free sugars in the Canadian diet: a research summary and future directions for food policy.

Until recently, most dietary guidelines and related food policies in Canada focused on total sugars, but recent evidence suggests that free sugars are of greater public health concern. Starting in 2017, our research group received federal funding to fill critical gaps related to free sugars and health. In this commentary, we describe our work related to tracking free sugars in the Canadian food supply and simulating the diet and health impacts of product reformulation. We then summarize how our work has influenced policymaking in Canada with examples of our knowledge translation efforts, and provide a future research and policy agenda based on our findings. Overall, there is significant room for Canadian food policies to target free sugars reductions in food and diets to address overconsumption of this nutrient of public health concern.

Value of narcotrend anesthesia depth monitoring in predicting POCD in gastrointestinal tumor anesthesia block patients

BackgroundThe purpose of this research was to evaluate the efficacy of Narcotrend (NT) monitoring on cognitive dysfunction in patients undergoing anesthesia blockade for gastrointestinal tumors and its effect on cerebral oxygen metabolism and inflammatory response.MethodsPatients preparing to undergo resection of gastrointestinal tumor resection were included and randomly divided into a control group (depth of anesthesia assessed by physician experience) and a research group (depth of anesthesia monitored by NT). HR and MAP were monitored at the preoperatively (T0), 12 h postoperative (T1), 24 h postoperative (T2), and 48 h postoperative (T3) stages. MMSE score was recorded to assess changes in cognitive function. Intracerebral oxygenation indicators (CjvO2, CERO2, and rSO2) were assessed by a blood gas analyzer. ELISA assay was conducted to explore the serum inflammatory indexes (CRP, IL-1β, and TNF-α) and neurological function indicators (NSE and MBP).ResultsMAP was higher in the research group than in the control group at T1 and T2 (P < 0.05). MMSE scores at T1, T2, and T3 stages were higher in the research group than in the control (P < 0.05). The incidence of POCD was also lower in the research group compared with the control (P < 0.05). CjvO2, CERO2, and rSO2 were significantly higher (P < 0.05) and were positively correlated with the MMSE scores. Postoperative serum inflammatory indexes were significantly elevated in both groups, but more significantly in the control group (P < 0.05). Both neurological function indicators were usually reduced after surgery, but the reduction was more significant in the research group (P < 0.05).ConclusionNT monitoring of anesthetic depth has a less physical impact on patients with gastrointestinal tumor anesthetic block, reduces the degree of postoperative POCD, and has significant clinical value.

A test method for assessing chronic oral toxicity of a pesticide to solitary nesting orchard bees, Osmia spp. (Hymenoptera: Megachilidae).

Orchard bees of the genus Osmia Panzerare important pollinators of fruit trees in various regions of the world, with some species commercially available in the United States and Europe. In addition to their pollination services, Osmia lignaria, Osmia cornifrons, Osmia bicornis, and Osmia cornuta have been identified as potential model species for solitary bees in pesticide risk assessment and have been used for the development of new methods to test acute lethal effects via contact and oral routes of exposure. Our goal was to expand the available methodology to characterize the toxicity of pesticides for these solitary bees through a chronic oral test for adult bees. Chronic oral toxicity of pesticides to orchard bees has been reported, but methods differ among research groups. In our study, O. lignaria, O. cornifrons, O. bicornis, and O. cornuta female bees had access to sucrose solution ad libitum in separate, species-specific 10-day tests. Mean body mass, mean daily consumption, and survival differed among the studied bee species. The dose-response test design was validated with dimethoate, a reference toxic compound, and chronic toxicity endpoints were estimated for the 4 Osmia species. The median lethal daily doses normalized by weight for O. lignaria, O. bicornis, O. cornuta, and O. cornifrons were within the same order of magnitude at 0.23, 0.26, 0.49, and 0.61 µg dimethoate/g bee/day, respectively. The methodology described here was aligned as much as possible with the available honey bee and bumble bee standard methods to facilitate the comparison of chronic toxicity profiles among bee species.

Recommendations for the creation of benchmark datasets for reproducible artificial intelligence in radiology

Various healthcare domains have witnessed successful preliminary implementation of artificial intelligence (AI) solutions, including radiology, though limited generalizability hinders their widespread adoption. Currently, most research groups and industry have limited access to the data needed for external validation studies. The creation and accessibility of benchmark datasets to validate such solutions represents a critical step towards generalizability, for which an array of aspects ranging from preprocessing to regulatory issues and biostatistical principles come into play. In this article, the authors provide recommendations for the creation of benchmark datasets in radiology, explain current limitations in this realm, and explore potential new approaches.Clinical relevance statementBenchmark datasets, facilitating validation of AI software performance can contribute to the adoption of AI in clinical practice.Key PointsBenchmark datasets are essential for the validation of AI software performance.Factors like image quality and representativeness of cases should be considered.Benchmark datasets can help adoption by increasing the trustworthiness and robustness of AI.Graphical

On Lubrication Regime Changes during Forward Extrusion, Forging, and Drawing

The tribological phenomena concerning the lubrication regime change (LRC) during bulk metal forming are comprehensively studied. A multi-step cold forward extrusion process shows the evolution of LRC and reveals the shortcomings of the traditional Coulomb friction law. The previous works of the specific author’s research group on friction are reviewed, focusing on the LRC during bulk metal forming. Various LRC phenomena from various examples are revealed. It has been found that the drawing and forward extrusion processes are vulnerable to LRC because of significant sliding motion at the material–die interface, and that when the strain hardening of the material is slight, the influence of friction increases, and as a result, the influence of LRC increases excessively. The new findings also include the impact of LRC on the macroscopic phenomena of the process and the reason for the sharp increase in friction coefficient via LRC, which is validated by the work of Wilson. This paper aims to make engineers and researchers think much of the tribology with lubricant in bulk metal forming with a focus on the dependence of tribological phenomena on the state of the lubricants and the irrationality of traditional friction law, especially in the forging of materials with a low strain hardening capability.

Development of Thermosensitive Hydrogel Mouthwash Loaded with Zingiber zerumbet Extract for Enhanced Oral Thrush Treatment

BackgroundOral thrush, caused by Candida albicans, is currently treated under guidelines by using topical antifungal pharmaceutical formulations such as lozenges and liquid gargles. Using these drugs may cause irritation and adverse reactions. Moreover, there is a short exposure time to reach the lesion, which may result in low effectiveness of the treatment. Therefore, the research group aimed to develop mouthwash solutions that can form gel at oral temperature containing Zingiber zerumbet rhizome extracts, which work as an active substance inhibiting fungi. MethodsThe development process began with the extraction of substances from Zingiber zerumbet rhizome using hexane and the analysis of the active substance by HPLC. Antifungal and anti-inflammatory activities of the extracts were evaluated. Hydrogel mouthwash was prepared by varying the type and concentration of polymer, solvent, and mucoadhesive agent. The optimized formulation was then evaluated for its properties. ResultsZingiber zerumbet rhizome extracts, containing 16.29±0.39 % zerumbone, demonstrated both antifungal and anti-inflammatory activities against Candida albicans. The extract also had anti-inflammatory activity when tested by the proteinase inhibitory test, with a percentage inhibition of 86.15±10.96 %. Two thermosensitive hydrogels, poloxamer P407 and P188, were applied and compared as gel-forming agents. It was found that the optimized formulation is composed of 15 % (w/w) poloxamer P407, 0.05 % (w/w) carbopol as a mucoadhesive agent, and 5 % (v/v) ethanol. Transition time and transition temperature of the optimized thermosensitive hydrogel formula were 27.76±1.25 s and 36±1.00 °C, respectively. The viscosity at shear rate 1 S-1 and 25 °C of the optimized formulation was 0.13±0.06 Pa.s, which is suitable for pouring out of the bottle and gargling. ConclusionThis study demonstrates a novel approach to developing thermosensitive hydrogel mouthwash formulations, leveraging Zingiber zerumbet rhizome extracts for enhanced therapeutic efficacy against oral candidiasis. These formulations offer prolonged contact time with affected areas, potentially improving treatment outcome.

Sustaining Ethical ePortfolio Practices: Insights from AAEEBL’s Task Force Year 4

This paper recognises the importance of digital ethics when using ePortfolios and provides information about the development of a comprehensive resource from the Association for Authentic, Experiential and Evidence-based Learning (AAEEBL) Digital Ethics in ePortfolios Task Force’s four-year work. With the public release of ChatGPT addressing ethical challenges in education is critical. Over three years, the global Task Force diligently drafted, refined, and published a suite of digital ethics principles, strategies, scenarios, and resources, which is available as open source. In the fourth year (July 2022-June 2023), the Task Force formed three sub-groups to manage the growing number of objectives. The Development group explored intersections between principles and generative artificial intelligence (GenAI), while evaluating data responsibility. The Outreach group disseminated the work through engaging workshops and publications, which also allowed the wider community feedback opportunities to further enhance the resources. Furthermore, the Research group undertook the ePortfolio Mapping Project to shed light on labour dynamics within ePortfolio practice across North America. The survey instrument was then adapted for data collection in Australia, and New Zealand. The paper highlights the significant achievements of these collective efforts, shares preliminary research findings, and offers valuable insights. It aims to promote ethical ePortfolio usage to enhance teaching, learning and assessment. Practitioner Notes Recognising potential ethical challenges in digital learning is critical. ePortfolios enable integrated learning experiences to meet a range of pedagogical objectives, including the tracking of learning processes as well as end artefacts. Learning how to apply ethical decision-making in using ePortfolios is essential. Comprehensive resources have been developed to assist educators, students, professional staff, and other digital pedagogy stakeholders. Research is underway into current ePortfolio practices which will inform future thinking, advocacy, and awareness.

DEVELOPMENT OF A COMPETENCY MATRIX IN A FRAMEWORK FOR THE PRACTICE OF RATIONAL MEDICINE USE IN THE TREATMENT OF SYSTEMIC ARTERIAL HYPERTENSION

Background: The use of medicines plays an important therapeutic role in the care of hypertension. Nonetheless, the inadequacies related to pharmacotherapy are still a major challenge to health, and the lack of systematisation of the competencies to be acquired during the training of health professionals undermines practices involving rational medicine use in the treatment of hypertension. This study was intended to develop and validate a competency matrix that can be used in the education and training of health professionals, contributing to the practice of rational medicine use (RMU) in the treatment of systemic arterial hypertension (SAH). Methods: This is applied research containing an integrative review and exploratory research with the presence of a systematic search, following guidelines proposed by the Cochrane Database of Systematic Reviews and the PRISMA group, and the building of the competency matrix was carried out through a focus group with researchers who work in the area registered in two research groups certified by an agency linked to the Brazilian Ministry of Education. The matrix was validated using the Delphi method by expert judges selected using Fehring’s technique and scoring criteria. Results: The panel of experts reached a consensus on the relevance of four intrinsic dimensions containing seven competencies and 31 knowledge, skills and attitudes of the RMU in SAH and three extrinsic dimensions that encompassed nine competencies and 22 knowledge, skills and attitudes of the RMU in SAH, with a frequency of agreement greater than 80%.