Research Group Research Articles

Guideline for RSA and CT-RSA implant migration measurements: an update of standardizations and recommendations.

Opening remarks: These guidelines are the result of discussions within a diverse group of RSA researchers. They were approved in December 2023 by the board and selected members of the International Radiostereometry Society to update the guidelines by Valstar et al. [1]. By adhering to these guidelines, RSA studies will become more transparent and consistent in execution, presentation, reporting, and interpretation. Both authors and reviewers of scientific papers using RSA may use these guidelines, summarized in the Checklist, as a reference. Deviations from these guidelines should have the underlying rationale stated.

Using social networks to study the political culture of modern China

The article systematizes the main approaches adopted by a group of researchers from MGIMO University, HSE University and the Institute of China and Modern Asia of the Russian Academy of Sciences, united within the framework of the ”Moscow Project for the Study of Chinese Political Culture”, to investigate the political culture of modern China through the monitoring of social networks. The authors analyze the existing ideas about political culture in the Chinese academic discourse, identify problems in studying the political views of Chinese citizens by traditional sociological methods (surveys, questionnaires). They further explain the relevance of using social network analysis in modern studies of Chinese society, and also describe the methodology they developed for studying social networks using sentiment analysis. The article lays the theoretical and methodological basis for further research on modern Chinese society based on an array of data from Chinese social networks.

Strategies to Design Chemocatalytic Racemization of Tertiary Alcohols: State of the Art & Utilization for Dynamic Kinetic Resolution.

The synthesis of enantiomerically pure tertiary alcohols is an important issue in organic synthesis of a range of pharmaceuticals including molecules such as the anti-HIV drug Efavirenz. A conceptually elegant approach to such enantiomers is the dynamic kinetic resolution of racemic tertiary alcohols, which, however, requires efficient racemization strategies. The racemization of tertiary alcohols is particularly challenging due to various side reactions that can occur because of their high tendency for elimination reactions. In the last few years, several complementary catalytic concepts for racemization of tertiary alcohols have been developed, characterized by efficient racemization and suppression of unwanted side-reactions. Besides resins bearing sulfonic acid moieties and a combination of boronic acid and oxalic acid as heterogeneous and homogeneous Brønsted-acids, respectively, immobilized oxovanadium and piperidine turned out to be useful catalysts. The latter two catalysts, which have already been applied to different types of substrates, also have proven good compatibility with lipase, thus leading to the first two examples of chemoenzymatic dynamic kinetic resolution of tertiary alcohols. In this review, the difficulties in racemizing tertiary alcohols are specifically described, and the recently developed complementary concepts to overcome these hurdles are summarized.

Alterations in oxidative phosphorylation complexes in arrhythmogenic cardiomyopathy using desmosomal KO cell model

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Instituto de Salud Carlos III (Fondo Investigación Sanitaria FIS) Introduction Arrhythmogenic cardiomyopathy (ACM) is an inherited disease that predominantly affects the right ventricle characterized by progressive cardiomyocyte loss and the replacement of the myocardium by fibro-fatty tissue, which can lead to sudden cardiac death (1). The main genetic causes of ACM are variants in desmosomal genes (PKP2, DSP, DSG2, DSC2 and JUP), representing up to 50% of patients (2). We lack sufficient understanding at molecular level of the pathophysiological mechanisms that may trigger ACM and determine its progression. Recent studies have proposed a deficit in transcripts encoding for proteins from the electron transport chain, which may be a potential ACM molecular signature in samples from patients with ACM carrying mutations in PKP2 (3). Purpose Our study aims to deepen into the knowledge of this proposed mechanism in PKP2 deficiency using edited cell model and elucidating whether these mechanisms are also triggered in DSG2 and DSC2 deficiency, being a potential common ACM pathomechanism, or they are gene specific. Methods HL-1 edited cell lines for desmosomal genes previously generated by CRISPR/Cas9 (PKP2-KO, DSC2-KO and DSG2-KO) in our research group were used to perform our analysis (4). Expression profiling was performed by RNA-seq analysis. To experimentally validate the RNA-seq analysis results, we performed western blot assays using total protein lysate to test protein levels of the five oxidative phosphorylation (OXPHOS) complexes for the PKP2-KO, DSC2-KO and DSG2-KO groups. To test if these differences have an impact at functional level, XFp cell Mito Stress Test (Agilent Technologies) was performed. Results RNA-seq analysis results showed numerous downregulated pathways related to aerobic respiration, the electron transport chain, oxidative phosphorylation and ATP synthesis in all three desmosomal KO lines. Our experimental results showed a significant reduction of the OXPHOS complexes of the mitochondrial respiration chain at protein level in all PKP2-KO, DSC2-KO and DSG2-KO (Fig. 1). At functional level, our preliminary results of Mito Stress Test suggest differences in basal and maximal respiration, ATP production, non-mitochondrial oxygen consumption and spare respiratory capacity between experimental groups. Conclusions Our results support previously published studies describing oxidative phosphorylation as a pathomechanism for PKP2 deficiency and also suggest that these mechanisms may be a common feature for desmosomal mutations in ACM.Total expression of OXPHOS complexes

Learning goals and level of individualism among undergraduate students

ABSTRACT Academic achievements are an important foundation for social mobility. Therefore, it is important to understand disparities between majority and minority groups in terms of such achievements. The present study was conducted in Israel, where previous research found differences between students from the Jewish majority and students from the Arab minority. Previous findings indicated that such gaps between groups were associated with learning goals and factors that the students indicated as reasons for choosing to study. The present research examined the relationships between these disparities and cultural differences found between the groups in previous research in individualism and collectivism. The sample consisted of 168 students (84 Arabic-speakers and 84 of Hebrew-speakers). Their levels of individualism and collectivism and their learning goals were measured when they began studying and their grades were collected later. In addition, parents’ education and some cognitive abilities were examined to establish that these variables did not explain the differences between groups. The findings indicate a significant difference between groups in final grades and in the interaction between level of individualism, learning goals, and final grades.

DESIGN SCENARIOS AND ECOTOPIAS. NOTES FOR THE DEVELOPMENT OF A SOCIO-ENVIRONMENTAL DESIGN LABORATORY

This paper presents the conceptual underpinnings organized by a group of designers and design researchers for the creation of the Ecotopias Socioenvironmental Design Laboratory at PUC-Rio University. It begins by discussing the anthropogenic crisis, which the planet is currently facing, and the consequent design crisis. It also presents the field of design for sustainability, its transversality and eco-logic possibilities. It situates the process of constructing scenarios in this field as a methodological option for opening the imaginative and anticipatory potential of art and design to confront the planetary environmental crises and regenerate ecologies of the mind, social relations, and the environment. It describes the methodological steps of the scenario-building process derived from the project Sustainable Everyday, and, finally, it distinguishes the concepts of utopia and ecotopia.

Loss of pitx2c causes early alterations in atrial calcium handling in zebrafish

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Ministry of Science, Innovation and Universities, Spain (PID2019-111456RB-100); Consejería de Educación, Cultura y Deportes, Junta de Comunidades de Castilla-La Mancha (SBPLY/19/180501/000223, co-funded by EU FEDER-ERDF) and grants for research groups from University of Castilla-La Mancha (2019-GRIN-27019, 2020-GRIN-29186 and 2022-GRIN-34301, co-funded by EU FEDER-ERDF) Introduction Atrial fibrillation (AF) is the most common cardiac arrhythmia in humans. Genome-wide association studies revealed that AF is related to sequence variants in chromosomic regions in close proximity to the transcription factor PITX2, involved in cardiac development and asymmetry, and in morphogenesis of pacemaker regions such as the sinoatrial region and the atrioventricular canal, which receive significant input from the autonomic nervous system. AF patients showed reduced PITX2 mRNA levels. PITX2-/- atrial tissue showed lower expression of CACNA1C accompanied by lower L-type Ca2+ current density. A recent study revealed AF-like phenotypes, including fibrosis, structural and metabolic alterations, arrhythmia, and cardiac conduction defects in adult pitx2c -/- zebrafish. Nevertheless, Ca2+ handling alterations remain unexplored in this zebrafish model. Purpose In this study we investigated cardiac Ca2+ handling in pitx2c deficient zebrafish. Methods We used the transgenic zebrafish line Tg(myl7:Twitch-4) expressing a fluorescent Ca2+ indicator in the heart. We outcrossed pitx2c+/- fish with Tg(myl7:Twitch-4) pitx2c+/- and studied Ca2+ dynamics and cardiac function by videomicroscopy in the beating hearts of 5 days post fertilization (dpf) larvae. Larvae were treated with 100 µM carbachol to assess differential response to parasympathetic stimulation in pitx2c deficient larvae. Results We observed sinoatrial pauses in 40 % of pitx2c+/- larvae accompanied by an increase in heart rate variability. In addition, pitx2c+/- and pitx2c-/- larvae at 5 dpf showed differential response to carbachol, a cholinergic agonist, compared to their wild-type siblings. Moreover, carbachol significantly decreased heart rate in pitx2c+/- and pitx2c-/- 5dpf larvae compared to siblings. Furthermore, we also observed a reduction of the amplitude of Ca2+ transients due to a decrease in the systolic Ca2+ levels in the atrium of pitx2c+/- larvae. The rise time of the atrial Ca2+ transient was prolonged, with a decrease in the rise slope. These data suggest a lower Ca2+ entry in the atrium. Interestingly, pitx2c+/- and wild-type larvae showed similar ventricular Ca2+ handling and contractility. Conclusion These results suggest that loss of pitx2c induce early Ca2+ alterations in the atrium as well as sinoatrial dysfunction in zebrafish during embryogenesis. Furthermore, pitx2c deficiency in zebrafish larvae possibly alters autonomic innervation leading to differentiated cardiac response to carbachol.

Clinical Research Primer for Medical Students: Overview & Illustrative Experiences

Background The ability to participate in clinical scholarship is a foundational component of modern evidence-based medical practice, empowering improvement across essentially every aspect of clinical care. In tandem, the need for comprehensive exposure to clinical research has been identified as a critical component of medical student training and preparation for residency that is underserved by traditional undergraduate medical education (UME) models. The goal of the current work was to provide guidelines and recommendations to assist novice medical students in taking ownership of their research education. Methods The Clinical Research Primer was composed from pooled research documents compiled by the study authors and our institutional neurosurgery student research group. The Primer was then structured as the natural evolution of a research project from its inception through the submission process. Results We divided the foundational components of the Clinical Research Primer into seven domains, each representing a landmark in the development of a peer-reviewed study, and a set of skills critical for junior scholars to develop. These vital components included the following: Pitching & designing clinical studies, developing a research workflow, navigating the Institutional Review Board (IRB), data collection & analysis, manuscript writing & editing, submission mechanics, and tracking research projects for career development. Conclusion We anticipate that the tools included in the Clinical Research Primer will increase student research productivity and preparedness for residency. Although our recommendations are informed by our experiences within neurosurgery, they have been written in a manner that should generalize to almost any field of clinical study.

An Equity-Based Research Agenda to Promote Social Inclusion and Belonging for People With IDD.

Having a sense of social inclusion and belonging, typically characterized by our personal relationships and community participation, is the central essence of life for most people, yet it remains elusive for many people with intellectual and developmental disabilities (IDD). This article summarizes the work of a diverse group of researchers and advocates to propose 6 big-picture, equity-based goals to drive future research in the field: (1) understanding the role of intersectionality, (2) understanding intimate relationships, (3) promoting formation of communities of care to support social inclusion, (4) understanding life course trajectories of social inclusion, (5) understanding social inclusion in virtual spaces, and (6) understanding how to promote social inclusion in the entire research process.

TDP-43 Is Associated with Subiculum and Cornu Ammonis 1 Hippocampal Subfield Atrophy in Primary Age-Related Tauopathy.

TAR DNA binding protein 43 (TDP-43) has been shown to be associated with whole hippocampal atrophy in primary age-related tauopathy (PART). It is currently unknown which subregions of the hippocampus are contributing to TDP-43 associated whole hippocampal atrophy in PART. To identify which specific hippocampal subfield regions are contributing to TDP-43-associated whole hippocampal atrophy in PART. A total of 115 autopsied cases from the Mayo Clinic Alzheimer Disease Research Center, Neurodegenerative Research Group, and the Mayo Clinic Study of Aging were analyzed. All cases underwent antemortem brain volumetric MRI, neuropathological assessment of the distribution of Aβ (Thal phase), and neurofibrillary tangle (Braak stage) to diagnose PART, as well as assessment of TDP-43 presence/absence in the amygdala, hippocampus and beyond. Hippocampal subfield segmentation was performed using FreeSurfer version 7.4.1. Statistical analyses using logistic regression were performed to assess for associations between TDP-43 and hippocampal subfield volumes, accounting for potential confounders. TDP-43 positive patients (n = 37, 32%), of which 15/15 were type-α, had significantly smaller whole hippocampal volumes, and smaller volumes of the body and tail of the hippocampus compared to TDP-43 negative patients. Subfield analyses revealed an association between TDP-43 and the molecular layer of hippocampal body and the body of cornu ammonis 1 (CA1), subiculum, and presubiculum regions. There was no association between TDP-43 stage and subfield volumes. Whole hippocampal volume loss linked to TDP-43 in PART is mainly due to volume loss occurring in the molecular layer, CA1, subiculum and presubiculum of the hippocampal body.

Transparent wood-based materials: A new step toward sustainability and circularity

Wood is a natural composite material mainly consisting of three components, i.e., cellulose, hemicellulose, and lignin. It exhibits a complex hierarchical structure characterized by open channels, aligned in the growth direction, having specific porosity at micro-, meso-, and macro-scale, and an extended opacity, due to adsorption phenomena because of the presence of lignin and scattering, as different refractive indexes characterize its components. Even if during the historical ages some of its applications have been replaced by other materials, wood still covers a large part of common uses, which range from biomass for energy recovery to material for the building sector, or from artifacts to household/furniture manufacturing. Despite its real invention dating to 1992, only about ten years ago two independent research groups, one from the University of Maryland (USA) and the other from the Royal Institute of Technology (Sweden) rediscovered and started to thoroughly investigate the so-called transparent wood (TW). TW can be derived from almost any wood biomass through specific chemical treatments focused on lignin. These aim to completely remove this component from wood or to eliminate the chromophore groups present in the pristine material, hence obtaining, after direct densification or after infiltration with a suitable polymer resin, a new material with very high transparency, toughness, and lightness. These characteristics can further be combined with other specific features (such as environmental protection, flame retardancy, photoluminescence, and energy storage ability, among others), which open the way toward the development of new, up-to-date, advanced, and sustainable materials for both structural and functional purposes, fulfilling the current concepts of circular economy and sustainability. The present review is aimed at providing the reader with an overview of the characteristics of transparent wood, describing the latest applications and, finally, discussing some challenging issues and perspectives for possible developments in the forthcoming years.

Pretos que voam – An Afrocentric Collective Project to Promote the Access of Peripheral Black People to Airline Crew Jobs in Brazil

Summary This case analyses the “Pretos que Voam” (Blacks who Fly) project, which aids the training of socially vulnerable black people to become flight attendants in Brazil. Since 2020, this project has been carried out by the collective Quilombo Aéreo, which brings together black crew members to aid the elimination of racism in aviation. One of the goals of this collective is to increase the representation of black people in the airline industry. Quilombo Aéreo ( 2022 ) conducted a survey of air crew members, using online forms based on self-identification, and found that black people do not reach 5% of active airline crews. The project is supported by crowdfunding and social partnerships like Fundação Tide Setúbal, Fundo Baobá for racial equity Rede de Mulheres Negras, Odabá Associação de Afroempreendedorismo, Movimento Negro Unificado and others. This made it possible to provide a complete course to become a flight attendant, a basic English course, air crew licences and a passport, and mentorship. In 2021, in Porto Alegre (RS), ten black people graduated in the first class – four women among them have already been hired by airlines. In 2022, the project raised funds to provide the first Afro-focused flight school in a distance learning model in Brazil. In 2023, they are working to start the operation of the school and crowdfunded a campaign for the second class of Pretos que Voam. Facing several forms of racism in Brazilian society and its airline industry, the project also dialogues with other forms of violence common in the sector, such as sexism and machismo . The case study examines concrete actions to transform the pain of its pioneers into fuel for structural changes, having as a framework the Afro culture and, as a scenario, a relevant mode of tourism transportation such as air travel. Information This case study originated from research into empowerment and intersectionalities between racism and sexism through the Quilombo Aéreo (see Further Reading). Here we focus specifically on the Pretos que Voam project, one of the actions developed by the collective. All authors are members of the research group Gritus – Gender, Race and Intersectionalities in Tourism , where this study was developed. Information © The Authors 2024

Comparative observation of the effectiveness and safety of remimazolam besylate versus dexmedetomidine in gastrointestinal surgery in obese patients.

Surgery for obese patients carries a higher risk of anesthesia complications compared with surgery for nonobese patients. Thus, a safe and effective anesthesia strategy is necessary to improve the medical experience of such patients and ensure their safety. To compared the effectiveness and safety of remimazolam besylate versus dexmedetomidine (DEX) in gastrointestinal surgery in obese patients. The study cohort included 60 obese patients undergoing gastrointestinal surgery between July 2021 and April 2023, comprising 30 patients who received DEX intervention (control group) and 30 patients who received remimazolam besylate intervention (research group). Heart rate (HR), respiratory rate (RR), mean arterial pressure (MAP), blood oxygen saturation (SpO2), safety (nausea and vomiting, bradycardia, hypotension, and apnea), anesthesia and examination indices [induction time, anesthesia recovery time, and postanesthesia care unit (PACU) discharge time], sedation effect (Ramsay Sedation Scale), and postoperative pain visual analog scale were comparatively analyzed before anesthesia (T0), during anesthesia (T1), and after anesthesia (T2). At T1, the research group showed significantly smaller changes in HR, RR, MAP, and SpO2 than the control group, with a significantly lower adverse reaction rate and shorter induction, anesthesia recovery, and PACU discharge times. Additionally, the intra- and postoperative Ramsay Sedation Scale scores were statistically higher in the research group than in the control group. Remimazolam besylate was significantly more effective than DEX in gastrointestinal surgery in obese patients and had a higher safety profile and value in clinical promotion.

Reversal of lipopolysaccharide-induced cardiomyocyte apoptosis via α7nAChR by dexmedetomidine.

This study aims to analyze the reversal of lipopolysaccharide (LPS)-induced cardiomyocyte apoptosis via α7nAChR by dexmedetomidine (Dex), so as to provide references for clinical treatment of myocardial disorders in the future. First, the research team divided cardiomyocytes (H9C2) were divided into a control group (normal culture), an LPS group (LPS-induced injury model), and an experimentalgroup (pretreated with Dex before LPS induction). Subsequently, lactate dehydrogenase (LDH) and cell activity were detected, and the research team found that the LDH content of the control, experimental and LPS groups were in ascending order (P<0.05). The cell viability decreased and apoptosis increased in the LPS group, with cells mainly concentrating in the G2-M phase; the viability increased and apoptosis decreased in the experimental group, with blocked G1-G0 phase (P<0.05).This demonstrates that Dex can reverse LPS-induced apoptosis in cardiomyocytes. Subsequently, the research group also detected the expression of α7nAChR and NF-κB/AKT pathway, and it was seen that the expression of α7nAChR in the LPS group was higher than that in the control group, with activated NF-κB/AKT pathway; the α7nAChR expression in the experimental group was further elevated, but the NF-κB/AKT pathway was inhibited (P<0.05). The effects of Dex on cardiomyocytes were seen to be related to the α7nAChR and NF-κB/AKT pathways.

Effect of high-flux hemodialysis plus compound-α Ketoacid tablets under humanistic care on calcium-phosphorus metabolism in uremia patients.

Uremia (UR) is a terminal renal failure manifestation with a very high risk of death, high-flux hemodialysis (HFHD) is currently the most common treatment for UR in clinical practice. In this study, we analysed the therapeutic efficacy of HFHD plus Compound-α Ketoacid Tablets for UR under humanistic care. Firstly, we randomised 100 patients with UR into a research group (RG) for HFHD plus Compound-α Ketoacid Tablets therapy and a control group (CG) for HFHD treatment, with both therapies implemented under humanistic care. By way of comparison, we found that the study group had significantly better renal function after treatment and they had a lower inflammatory response. Also, the study group showed lower calcium and phosphorus metabolism and better immune function. Based on these results, we believe that HFHD + Compound-α Ketoacid Tablets under humanistic care have high clinical value.

AlgoRitmo Literacies In Gaming: Leveraging Chicanx Praxis To Reimagine AI Systems

ABSTRACTThis article reports on findings from a social design‐based study conducted with an intergenerational group of youth, educators and researchers participating in the Learning to Transform (LiTT) Gaming Lab. We advance the notion of AlgoRitmo Literacies, to highlight the ingenuity of youth and educators as they used a tool called Character AI to author lore emerging within a virtual city called LiTT City. We conceptualize AlgoRitmo—a play on the word algorithm—as part inquiry and reflection (the algo or “something” of AI tools), and part action and future‐oriented (ritmo as in movement). Inspired by cosmogonies influenced by Coyolxauhqui, the fragmented Aztec moon goddess, this paper illustrates how young people reconfigure AI artifacts, reshape relationships with AI‐governed non‐playable characters, and repurpose AI tools to envision alternative futures and identities. In identifying AlgoRitmo Literacies, we provide examples of how ChicanX communities subvert ideologies embedded in AI through creative and ingenious interventions in video games and the construction of cyborg Chicanx subjectivities. This paper offers implications for how educators across content areas can leverage gaming, and AI tools, toward consequential literacy development.

Saved by the Moon: Imaginaries of Earthly Afterlife in Space

Today, emergent space technology engages in visions of future off-world colonizing, while conservation technology is employed in ensuring the continuation of life on earth. In this article, we combine social science of outer space literature with biodiversity conservation work to analyze how utopian visions of off-world futures and dystopian visions of earth entangle in technoscientific future-making practices. Our case is the Lunar Ark, which is a proposed technoscientific project for a conservation base to be assembled inside the moon’s lava tubes comprising samples of the earth’s ecosystems. We investigate two interwoven imaginaries involving an imaginary of the Lunar Ark as a “reseeding of earth” and secondly, an imaginary in which the Lunar Ark becomes a platform for “escaping earth.” Based on scientific papers, web material, news articles, an interview with the head of the research group, and ethnographic observations, we conclude that the Lunar Ark engages with a speculative bioeconomy, wherein earth is imagined as an unstable and unfit protector of life. In contrast, the Lunar Ark emerges as a pan-humanitarian and maternal-like technoscientific environment.

A comprehensive characterization of Hermetia illucens derived chitosan produced through homogeneous deacetylation

The increasing demand for chitin and chitosan is driving research to explore alternative sources to crustaceans. Insects, particularly bioconverters as Hermetia illucens, are promising substitutes as they process food industry waste into valuable molecules, including chitin. Chitosan can be produced by chitin deacetylation: hot deacetylation to obtain a heterogeneous chitosan, the commonly produced, and cold deacetylation to obtain a homogeneous chitosan, not widely available. The two different treatments lead to a different arrangement of the amine and acetyl groups in the chitosan structure, affecting its molecular weight, deacetylation degree, and biological activity. This is the first report on the production and chemical-physical and biological characterization of homogenous chitosan derived from H. illucens larvae, pupal exuviae, and adults. This work, in addition to the report on heterogeneous chitosan by our research group, completes the overview of H. illucens chitosan. The yield values obtained for homogeneous chitosan from pupal exuviae (3 and 7 %) are in the range of insect (2–8 %) and crustaceans (4–15 %) chitosan. The evaluation of the antioxidant activity and antimicrobial properties against Gram-negative (Escherichia coli) and Gram-positive (Micrococcus flavus) bacteria confirmed the great versatility of H. illucens chitosan for biomedical and industrial applications and its suitability as an alternative source to crustaceans.

Mechanisms of Change in Exposure Therapy for Anxiety and Related Disorders: A Research Agenda

Anxiety and related disorders are a significant public-health burden with rising prevalence in the wake of the COVID-19 pandemic. As demand for effective anxiety treatment increases, so too does the need for strategies to bolster treatment outcomes. Research on the mechanisms of exposure therapy, the frontline behavioral treatment, will be critically important for optimizing clinical outcomes. We outline an initial agenda for future research on the mechanisms of change of exposure therapy, developed in collaboration with a large international team of researchers through the Exposure Therapy Consortium. Key questions and recommendations for future research focus on four priority areas: conceptualization, measurement, study design/analysis, and individual/contextual differences. Rising to the challenge of addressing these questions will require coordinated action and availability of centralized tools that can be used across trials, settings, and research groups.

Research on Madrasas in International Publications: Bibliometric Analysis with Vosviewer

The large number of studies on madrasas on Scopus means that madrasas can be used as an option for researchers in conducting research. This research aims to look at the grouping and novelty of keywords using Vosviewer. This research used 323 documents that had been sorted according to keywords. From the results of the analysis, there are fourteen research groups based on keywords in madrasa research in the Scopus database, namely improving educational practices in madrasas, developing madrasa education in rural areas, preserving architectural heritage in madrasas, improving the Arabic language curriculum in Aliyah madrasas, Islamic pedagogy and practice. memorization, heritage preservation and restoration techniques, Islamic boarding school management, integration of character in online learning during the pandemic, madrasas and maktab religious education and national training, teacher performance and academic achievement, development of religious character, leadership in moral education, environmental learning in Muslim communities, as well as the study of Islamic history. Meanwhile, the novelty of keywords such as mausoleum, Islamic boarding schools, learners, character building, online learning, emotional intelligence, critical thinking skills, and learning outcomes indicates the novelty of the keywords so that these keywords can be used as research recommendations in research on madrasas in the Scopus database.