<h3>Objectives</h3> To evaluate the awareness of patients using bisphosphonates (BFs) regarding their risks and benefits. <h3>Study Design</h3> A cross-sectional study was performed. Sixty-five patients seen at a dental school clinic and at a rheumatology ambulatory of a teaching hospital, all users of BFs, were included in the study. Each participant completed a self-administered questionnaire, which consists of 13 questions, including sociodemographic and general information on BF. Data were analyzed using descriptive statistics, and a chi-square test was used to assess the correlation between the variables, considering a 5% significance level. <h3>Results</h3> Fifty-nine patients were unaware of or had not heard of BF group drugs (90.2%) and only 3 knew their indications (4.6%). Only 6 patients said they knew about the oral complications caused by BFs (9.2%). Sixty-three patients said they had not been referred to the dentist before starting BF treatment (96.9%). Patients using BFs do not have satisfactory knowledge regarding the risks and benefits of BFs. <h3>Conclusions</h3> Our results emphasize the importance of public policies, whether individual or collective, to increase knowledge about BFs to avoid medication-related osteonecrosis of the jaw.