Link for citation: Balobanenko A.A., Vasilyev D.I., Dutova E.M., Kuzevanov K.I. Analysis of changes in groundwater levels in quaternary deposits in the south-eastern part of the Irtysh-Ob artesian basin. Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering, 2023, vol. 334, no. 7, рр. 202-213. In Rus. Relevance. The tasks of studying the level regime of groundwater are very closely related to the need to predict their resources under the influence of both natural and artificial factors in order to develop scientific foundations for the rational use of water resources and effective management of the groundwater regime in the study area. Purpose: to study changes in the level regime of groundwater for domestic and drinking purposes in Quaternary deposits in the south of the West Siberian artesian basin based on the results of long-term regime observations. Objects: groundwater of the Irtysh-Ob artesian basin of the II order, the southeastern part of the West Siberian artesian basin of the I order, most actively involved in the sphere of anthropogenic activity. The study area is confined to a province with stable seasonal freezing of the aeration zone, where the main groundwater recharge is carried out in the spring due to snowmelt. Methods. The methodology for conducting observations of groundwater levels was determined by the regulations of the former USSR Ministry of Geology, and then the Ministry of Natural Resources of the Russian Federation, this paper presents a statistical processing of time series of observations of groundwater levels and a comparison of the results obtained with the data on the water regime of surface watercourses and climatic characteristics of the study areas. Results. The leading influence of climatic conditions on the main regularities of the natural hydrodynamic regime of groundwater was revealed. A different degree of intensity of the influence of external factors is shown, expressed by the amplitude of the groundwater level, depending on the type of groundwater regime and the degree of moistening of the territory. Natural factors have the least effect on groundwater as they move away from draining ones and with increasing depth.