This study aims to investigate the impact of climate change on heat-related mortality in Southeast Asia in the future. The ensemble mean from five General Circulation Models (GCMs) including the Flexible Global Ocean-Atmosphere-Land System Model: Grid-Point Version 3 (FGOALS-g3), Max Planck Institute Earth System Model Version 1.2 (MPI-ESM1-2-LR), EC-Earth3, The Meteorological Research Institute Earth System Model Version 2.0 (MRI-ESM2-0), and Geophysical Fluid Dynamics Laboratory Earth System Model Version 4 (GFDL-ESM4) was used to project severe temperatures and heat indices in Southeast Asia under the Coupled Model Intercomparison Projects Phase 6 (CMIP6). This data was used to correlate with mortality data from the Global Burden of Disease database to quantify heat-related mortality in the region. The ensemble mean results show a reasonable level of accuracy in capturing temperature patterns in the Southeast Asian region with an R2 of 0.96, root mean square error (RMSE) of 0.84 and a standard deviation of residual (SDR) of 0.02. When compared to the baseline (1990–2019), temperature extreme indices are rising across all climatic scenarios, with a substantial increase in the SSP3–7.0 and SSP5–8.5 scenarios, ranging from 10% to 50% over the regions, with the heat index predicted to peak in the middle of the century. The two low-emission scenarios, SSP1-2.6 and SSP2-4.5, on the other hand, anticipate more moderate increases, indicating a potentially less severe impact on the region. As a result, under high-emission scenarios, there is expected to be a significant increase in heat-related mortality across Southeast Asia. The expected impact is estimated to affect between 200 and 300 people per 100,000 people from 2030 to 2079, accordingly. Our results highlight the critical need to address health-related impacts of climate change in this region.
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