Great Impact Research Articles

Study of Salvation based on 1 Peter 3:18-22 among Batak Toba Christians, North Sumatra

Salvation is a very broad subject and very important to understand properly in the Bible. Salvation in Jesus Christ can be responded to by believing in Christ and His work. The understanding of salvation is now understood in universalism, and not a few people or groups have also turned to syncretism. The emergence of many teachers, pastors, and theologians had a great impact on providing different understandings among Christians. Each tribe has a belief in their ancestors, which later becomes a culture or custom. Initially, every Batak culture or custom was inseparable from magical elements. Any rituals or traditional ceremonies performed by certain groups or people are believed to keep them away from danger so that they are fine. But in reality, not a few of them experience the opposite. The initial motivation for getting blessings and safety turns out to be the tribulation or wretchedness that befalls their lives. The purpose of this research is to find out the magnitude of the confirmation of salvation in Jesus Christ. The most dominant dimension determines the confirmation of salvation, and the most dominant background category determines the confirmation of salvation based on 1 Peter 3:18-22 among Batak Toba Christians in Sumatra North. The method used is a quantitative approach using explanatory and confirmatory surveys. Research Results: Confirmation level about salvation based on 1 Peter 3:18-22 is in the high category. The most dominant dimension determining Confirmation about salvation is Preaching the Gospel by Jesus Christ (D3). The dominant background category determining confirmation of safety is age.

Innovative post-traumatic ectropion repair – A case report

Eyelid ectropion is the outward turning of the eyelid away from the globe of the eye. Trauma is one of the acquired causes of ectropion. The scar can pull the eyelid and lead to cicatricial ectropion. It causes dryness of the eye, watering, exposure to keratitis, and a great psychological impact on the patient. Correction is needed to protect the eye and improve esthetic appearance. Many treatment modalities, such as regional flaps and transconjunctival flaps, were described earlier which are complex. We present an innovative approach to post-traumatic ectropion repair with simple scar revision and threads.

The Influence of Diffuse-Field Equalization on the Perception of Spatial Aliasing Introduced by Spherical Microphone Arrays

When a sound field is sampled by a finite number of microphones, the upper-frequency range of the recorded content is affected by spatial aliasing. The frequency beyond which aliasing-induced artifacts occur is related to the distance between a microphone and its nearest neighbors. In this study, ambisonics signals of order N = 7 were encoded from simulated recordings made by virtual spherical microphone arrays of varying characteristics (radius, sampling scheme, and sampling grid order). A diffuse-field equalization, the role of which is to lessen the aliasing-induced spectral coloration, was also considered in the tested conditions. These aliased stimuli were then compared with unaliased stimuli of order N = 7. Results showed that the diffuse-field equalization had a great impact on the perceived differences. A perceptual threshold was calculated in order to determine whether aliasing artifacts are likely to be audible based on the amount of aliasing-induced encoding error.

Comprehensive evaluation and guidance of structural variation detection tools in chicken whole genome sequence data

BackgroundStructural variations (SVs) are widespread across genome and have a great impact on evolution, disease, and phenotypic diversity. Despite the development of numerous bioinformatic tools, commonly referred to as SV callers, tailored for detecting SVs using whole genome sequence (WGS) data and employing diverse algorithms, their performance necessitates rigorous evaluation with real data and validated SVs. Moreover, a considerable proportion of these tools have been primarily designed and optimized using human genome data. Consequently, their applicability and performance in Avian species, characterized by smaller genomes and distinct genomic architectures, remain inadequately assessed.ResultsWe performed a comprehensive assessment of the performance of ten widely used SV callers using population-level real genomic data with the validated five common types of SVs. The performance of SV callers varies with the types and sizes of SVs. As compared with other tools, GRIDSS, Lumpy, Wham, and Manta present better detection accuracy. Pindel can detect more small SVs than others. CNVnator and CNVkit can detect more medium and large copy number variations. Given the poor consistency among different SV callers, the combination calling strategy is not recommended. All tools show poor ability in the detection of insertions (especially with size > 150 bp). At least 50× read depth is required to detect more than 80% of the SVs for most tools.ConclusionsThis study highlights the importance and necessity of using real sequencing data, rather than simulated data only, with validated SVs for SV caller evaluation. Some practical guidance and suggestions are provided for SV detection in future researches.

Obituary: A life devoted to bee protection: the legacy of Pieter Oomen

Dr. Pieter Oomen, born in 1946, a prominent and inspirational scientist in many areas of the biosafety of pesticides, most notably ecotoxicology, regulatory, risk assessment and bioassays, passed away peacefully on 19th of January 2024. His efforts have had a great and long-lasting impact on bee risk assessment and have improved bee protection. While we will miss a very warm and brilliant person; his many contributions to science and our ability to detect and mitigate risks to the environment remain.

Stimulating ambulance specialist nurse students' ethical reflections by high-fidelity simulation.

Introduction: Ethical competence in professional practice can be considered essential among nurses and nurses in ambulance care encounter ethical dilemmas frequently. To enhance ethical competence among students in the ambulance specialist nursing program, high-fidelity simulation scenarios including ethical dilemmas were introduced as a learning activity. Research aim: The research aim was to investigate the usefulness of high-fidelity simulation in ambulance specialist nurse education to teach ethical reasoning when caring for children. Research design: This study was conducted as a qualitative interview study, complemented with observations and using field notes and qualitative interviews for data collection. Data was analysed using deductive qualitative content analysis based on a care ethical model. Participants and research context: Participants (n = 35) were recruited from an ambulance nurse educational program at a Swedish university. Data was collected after the students took part in two high-fidelity simulations involving children in an ambulance care setting. Ethical considerations: The study has been vetted and approved by the ethical council at the University of Borås, Sweden. The study follows the Helsinki Declaration's advice on ethical principles. Results: The results showed that most of the students expressed some form of ethical reasoning during the simulation sessions, which were elaborated and reflected upon during the debriefing part of the sessions. The simulation design seemed to have a great impact on the outcome of the student's ethical reasoning, where increased immersion led to deeper emotional engagement among the students which increased awareness of their personal preconceptions. Conclusions: This study aimed to investigate whether high-fidelity simulations could be useful to stimulate ethical reflections and contribute to increased ethical competence among students. In conclusion, a well-designed high-fidelity simulation can be useful as an educational tool to learn and enhance ethical competence among specialist ambulance nursing students.

Moving on from clinical animal-derived surfactants to peptide-based synthetic pulmonary surfactant.

Research on lung surfactant has exerted a great impact on newborn respiratory care and significantly improved survival and outcome of preterm infants with respiratory distress syndrome (RDS) due to surfactant deficiency because of lung immaturity. Current clinical, animal-derived, surfactants are among the most widely tested compounds in neonatology However, limited availability, high production costs, and ethical concerns about using animal-derived products constitute important limitations in their universal application. Synthetic lung surfactant offers a promising alternative to animal-derived surfactant by providing improved consistency, quality and purity, availability and scalability, ease of production and lower costs, acceptance, and safety for the treatment of neonatal RDS and other lung conditions. Third-generation synthetic surfactants built around surfactant protein B (SP-B) and C (SP-C) peptide mimics stand at the forefront of innovation in neonatal pulmonary medicine, while nasal continuous positive airway pressure (nCPAP) has become the standard non-invasive respiratory support for preterm infants. nCPAP can prevent the risk of chronic lung disease (bronchopulmonary dysplasia) and reduce lung injury by avoiding intubation and mechanical ventilation, is a relatively simple technique and can be initiated safely and effectively in the delivery room. Combining nCPAP with noninvasive, preferably aerosol, delivery of synthetic lung surfactant promises to improve respiratory outcomes for preterm infants, especially in low-and-middle income countries.

Health assessment method of front landing gear hydraulic retraction and extension system based on GRNN

With the continuous development of civil aircraft health management technology, the status monitoring data of important aircraft systems and components are constantly enriched. The health status of the front landing gear hydraulic retraction system has a great impact on the take-off and landing of the aircraft. Although the system has multi-dimensional monitoring parameters, it is difficult to effectively use the system monitoring data to accurately evaluate its health status. Aiming at the health assessment problem of the front landing gear hydraulic retraction system, this paper builds a simulation model of the system through AMESim software modeling, and studies the influence of the performance changes of hydraulic component parameters on the front landing gear retraction performance. The performance data of the front landing gear retraction actuator at different levels of failure are used as the original data, and the characterization parameters such as retraction time and maximum flow rate are extracted. A health index construction method based on generalized regression neural network (GRNN) is proposed, which can more effectively evaluate the health status of the system. Its effectiveness and accuracy are proved by method comparison.

Research on Temperature Change Law and Non-Uniform Distribution Characteristics of Electromagnetic Control Roll Based on Rotating Heat Flow

The uniform temperature distribution on the surface of the electromagnetic control roll (ECR) has a great impact on the quality of the strip; therefore, temperature control is essential. In order to study this issue, a two-dimensional volume of fluid (VOF) model was established using the simulation software FLUENT (2024 R1) to analyze the radial cooling capacity and surface temperature uniformity of the ECR under different process parameters, and an experimental validation was carried out at the same time. The error between the experiment and the model was less than 5% of the maximum temperature, proving the model is accurate. The results of the analysis show that the use of a controlled temperature mode has an effect on the cooling capacity and the speed has no effect on the cooling capacity. The temperature difference between the two sides of the ECR is too large, which will make the uniformity of the ECR surface temperature worse. While too high or too low, a roll speed and coolant injection speed will increase the non-uniformity of the ECR surface temperature; when the roll speed is 12 rad/s or coolant injection speed is 5 m/s, the ECR surface temperature distribution uniformity is the best. Properly adjusted process parameters can improve the cooling performance and ECR surface temperature uniformity.

Movable VOC Removal System

In this study, we develop a mobile VOCs gas removal system that can remove volatile organic compound (VOCs) emissions from petrochemical facilities, metal painting factories, and surroundings of life, and can efficiently cope with situations occurring in the field. Regular repairs to petrochemical plants and semiconductor plants are carried out for a month every four to five years, and work such as replacing old pipes and repairing aging facilities, cleaning, removing residual gas, checking pipe connections and valves, and improving processes are carried out while the plant is shut down. During regular maintenance, a large-scale accident occurs in which gas remaining in the facility leaks or explodes due to rising pressure, and even after internal gas discharge and purge work is performed, it is scattered by the characteristics of raw materials remaining inside the pipe and reactor and discharged into the atmosphere. Therefore, there is always a possibility of causing safety accidents, and such accidents have a great socioeconomic impact as they are directly connected to the safety of workers as well as the safety of local residents. This system is designed to be adaptable according to the size of a number of outlets, and it is proposed to minimize the impact of VOCs harmful gases on the surroundings by developing it as a mobile type. The efficiency of collecting scattered VOCs gas is more than 90%, and the integrated operating system is demonstrated for 50 CMM class movable VOCs adsorption device, 5 CMM class treatment gas recirculation type non-flame waste heat recovery adsorbent regeneration treatment device, and two or more business sites.

The Long Tail of Conflicts in Innovation Projects: Conflicts and Their Impact on Strategic Renewal

Conflicts in projects are often resolved at the project level; however, if handled properly, resolving conflicts creates learning opportunities of great impact for the wider organization. In this article, we investigate the relationship between conflicts, their resolution, and the effect on the strategic renewal of the organization. We draw on a three-year case study at Bang & Olufsen to develop a process model that shows that conflict resolution can have a positive “long tail” that can lead to strategic renewal.

Neutrophil extracellular traps as an important part of the pathogenesis of chronic rhinosinusitis without polyps

Background. Chronic sinusitis occurs in the Russian Federation in 16.4±10.89% of the population and has a great impact on the quality of life of patients. The inflammatory process underlying this pathology is often resistant to conservative treatment and causes surgical intervention. The study of the role of neutrophil extracellular traps as an important part of the immune response, as well as the capabilities of drugs capable of influencing the processes of netosis, is an important and relevant area of modern research. Aim. Studying the role of NETs in the pathogenesis of CRS without polyps, assessing the effect of azoximer bromide on the metabolism of NETs in patients with CRS. Materials and methods. The study included 82 patients diagnosed with chronic rhinosinusitis (average age 37±12 years), and 40 healthy volunteers (average age 34±10 years). Patients with CRS were treated with surgery and a course of azoximer bromide, the severity of the disease did not differ in patients. Nasal secretions and venous blood were analyzed in all study participants with the determination of surrogate markers of neutrophil extracellular traps – myeloperoxidase complexes with DNA and the detection of double-stranded DNA (Quant Pico Green dsDNA kit). In patients who received azoximer bromide, the material was taken twice – before the start of treatment and 10 days after the course of treatment. Results. In patients with CRS, the amount of NETs in nasal secretions and venous blood is higher compared to the control group (p0.05). The use of azoximer bromide in CRS outside of exacerbation reduces the activity of NETosis processes with intranasal use of the drug not only in the area of inflammation (reduction of NET in nasal secretions); p0.05, but also at the general level (decrease NETs in venous blood); p0.05. Conclusion. An increase in the amount of NETs in nasal flushes and venous blood in patients with CRS without exacerbation compared with the control group may indicate a likely pathological role of NETosis processes, and an increase in the amount of NETs in the blood of patients with CRS without exacerbation compared with the control group indicates the systemic effect of a local inflammatory process in the mucous membrane of the nasal cavity and paranasal sinuses.

Secondary students’ beliefs about English L2 speaking fluency

Research findings on beliefs in second language acquisition (SLA) suggest that beliefs can have a great impact on language learners’ approach to learning, the manner in which they complete language learning tasks, and their ability to complete those tasks and achieve their goals (Griffiths &Soruç 2020). This study explores secondary students’ beliefs about English L2 speaking fluency, their own performance on argumentative dialogues, and possible changes in these beliefs over an eight-month period. Speaking fluency is a multifaceted construct and it is a widely used term in both everyday and research contexts (Tavakoli& Wright 2020). These factors might result in the coexistence of multiple conceptualisations of fluency in a given context. This study argues that this coexistence might also entail inconsistent and even contradictory beliefs about speaking fluency and the components that need to be developed to achieve it. Moreover, these beliefs might change over time. The participants were twelve secondary students in an English bilingual programme (16-year-olds: 11 females and 1 male) who audio-recorded their English L2 argumentative dialogues throughout a school year (10-13 discussions over the eight months). They completed reflective journals in Hungarian, in which they answered questions on how they felt during the dialogues, what areas they felt good and bad at, and what and how they wanted to develop in the future. In addition, they completed a qualitative questionnaire at the beginning and end of the research which focused on their conceptualisation of speaking fluency, the factors they considered important, and their language learning habits and background. The findings showed that the participants had diverse and sometimes contradictory beliefs about speaking fluency and the components that are important to develop, and that these beliefs also changed over time for some participants. / Keywords: beliefs about speaking fluency, introspective methods, reflective journals, experience sampling

Exploration of the Extended World of the 13 Characters in Weiliaozi

In addition to the Establishing the first unified empire in East Asia XiHuang (始皇) and HanFei (韩非) active political and military activities, WeiLiao (尉缭) had a great impact on the unification of the six countries of Qin in the late Zhanguo Period with his political purpose and concept of "XingDe (刑德)". This weiliao's military and political rule and its theory were the metric development that later brought about the legalization of territory and system and the perfection of Qin (秦) 18's legal system, which was the driving force for the development of science, technology and civilization. If can grasp the background of the pivotal figures and events in the history of the times and their causes, and rediscover the literature and artifacts with regional characteristics as a scene of a long history, the regions and their boundaries that can be seen in the whole map of the 21st century are not only the territorial boundaries divided and staged. As an integrated media of the behavior product of the human community, its epistemological objects, whether paper or digital, have a great impact on the globalization (the whole area) of the global village.

Rice husk biochar is more effective in blocking the cadmium and lead accumulation in two Brassica vegetables grown on a contaminated field than sugarcane bagasse biochar.

Heavy metal-contaminated soil has a great impact on yield reduction of vegetable crops and soil microbial community destruction. Biochar-derived waste biomass is one of the most commonly applied soil conditioners in heavy metal-contaminated soil. Different heavy metal-contaminated soil added with suitable biochars represent an intriguing way of the safe production of crops. This study investigated the effects of two types of biochar [rice husk biochar (RHB) and sugarcane bagasse biochar (SBB)] on Cd and Pb accumulation in Shanghaiqing (SHQ, a variety of Brassica campestris L.) and Fengyou 737 (FY, a variety of Brassica napus), as well as on the soil microbial community, through a field experiment. RHB and SBB were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and Brunauer-Emmet-Teller method. The results showed that RHB and SBB displayed the higher pH, cation exchange capacity and pore properties, and the addition of RHB and SBB enhanced soil pH and rhizosphere microorganisms promoting vegetables yield. RHB treatments were more effective than SBB in reducing upward transfer of Cd and Pb, blocking the accumulation of Cd and Pb in the edible parts of SHQ and FY, and decreasing soil Cd and Pb bioavailability. Additionally, RHB and SBB changed the composition of the rhizosphere soil microbial community. The application of biochar promoted the growth of ecologically beneficial bacteria (Nitrospira, Opitutus, and Gemmatimonas) and fungi (Mortierella and Holtermanniella), whereas reducing the enrichment of plant pathogenic fungi (Alternaria, Stagonosporopsis, Lectera, and Periconia) in rhizosphere soil. Our findings demonstrated that the application of RHB significantly reduces Cd and Pb accumulation in the edible parts by decreasing the soil Cd and Pb bioavailability and altering the rhizosphere microbial community composition in two Brassica vegetables grown on Cd/Pb-contaminated soils. Thus, the application of two biochar, especially RHB is a feasible strategy for the safe production of vegetable crops in Cd/Pb co-contaminated soils.

Educational Diplomacy of Islamic Republic of Iran as the Soft Power Strategy in the Middle East

Nowadays, many countries are trying to increase their soft power authority using the university communication facilities. Educational exchanges and the creation of university branches in different parts of the world, especially in countries where there are common cultural fields, give these countries the opportunity to interact with elites and students expand their influence. The university sector, as the most important and effective branch in creating the future of a country, will have a great impact on understanding and cultural alignment between nations.In this regard, one of the important regions that have a lot of common cultural identity with the Islamic Republic of Iran is the Middle East region. This article aims to answer the question of how the Islamic Republic of Iran can use its academic capabilities as the educational diplomacy in order to promote its position as soft power in the Middle East. Accordingly, Iran can use the cultural capacities, the Persian language, the common background of civilization and the capability of its higher education, especially in the field of university exchanges to empower its soft power authority in the region.

Bioinformatic Characterization of the Functional and Structural Effect of Single Nucleotide Mutations in Patients with High-Grade Glioma.

Background: Gliomas are neoplasms of the central nervous system that originate in glial cells. The genetic characteristics of this type of neoplasm are the loss of function of tumor suppressor genes such as TP53 and somatic mutations in genes such as IDH1/2. Additionally, in clinical cases, de novo single nucleotide polymorphisms (SNP) are reported, of which their pathogenicity and their effects on the function and stability of the protein are known. Methodology: Non-synonymous SNPs were analyzed for their structural and functional effect on proteins using a set of bioinformatics tools such as SIFT, PolyPhen-2, PhD-SNP, I-Mutant 3.0, MUpro, and mutation3D. A structural comparison between normal and mutated residues for disease-associated coding SNPs was performed using TM-aling and the SWISS MODEL. Results: A total of 13 SNPs were obtained for the TP53 gene, 1 SNP for IDH1, and 1 for IDH2, which would be functionally detrimental and associated with disease. Additionally, these changes compromise the structure and function of the protein; the A161S SNP for TP53 that has not been reported in any databases was classified as detrimental. Conclusions: All non-synonymous SNPs reported for TP53 were in the region of the deoxyribonucleic acid (DNA) binding domain and had a great impact on the function and stability of the protein. In addition, the two polymorphisms detected in IDH1 and IDH2 genes compromise the structure and activity of the protein. Both genes are related to the development of high-grade gliomas. All the data obtained in this study must be validated through experimental approaches.

Ancient Mythology in “La Princesse Maleine” by Maurice Maeterlinck: Intertextual Analysis

The article is devoted to the reconstitution of the mythological worldview of the well-known European Symbolist writer Maurice Maeterlinck based on his famous drama ‘Princess Maleine’ that made a great impact on the development of the ‘new drama’ in the end of the 19th century. This analysis is performed in the context of the study of the symbolist semiotic system in French-speaking tradition. The lingua-poetic and mythopoeic intertextual analysis done, we have found that the mythological model in the play is functioning with a large system of mythological structures and semantic patterns. The locus of ‘Princess Maleine’ is marked as Hades World and its inhabitants are connoting the mythical concept BAD LUCK. Only two actors, the protagonists Maleine and Hjalmar are connoted not only by the morbid semantics but also as the correlates of the astral world. Their death in Hades makes possible the eschatological catastrophe leading to the neutralization of the killers whereas the infernal semantics is neutralized and the cosmos tends to the restoring of harmony symbolized by the coming of the new day and of the new year. Besides, the protagonists are considered to be the sacred sacrifice to change the semantics of the mythological concept BAD LUCK to the harmonized GOOD LUCK. Three mythological models are reconstructed: LIFE with positive connotation, LIFE with negative connotation and DEATH with positive connotation. The projection of the play is modeled by the movement from the positively and negatively connoted concept LIFE to the positively connoted concept DEATH that is a distinctive sign of Symbolist conception of ‘tragic optimism’ developed by Maeterlinck.

Long-term alien marsh grass in China brings high carbon uptake capacity but cannot sustain high-temperature weather

Coastal wetlands, crucial in the global carbon cycle, face increasing challenges brought by extreme climate events, particularly high temperatures above plant tolerance thresholds. These conditions often exert great impact on plant, thereby potentially reducing overall ecosystem productivity. However, it has been observed that alien species, typically exhibiting higher productivity compared to native plant. Would plant invasion offset the loss of productivity caused by high-temperature events at ecosystem scale? In this study, we utilized data from 2020 to 2023 in China's Yangtze Estuary to investigate the responses of Spartina alterniflora (alien) and Phragmites australis (native) to high-temperature stress. Our results demonstrate that though the alien vegetation exhibits higher productivity before high temperature events, it experiences significant declines during high temperatures. In average, net ecosystem productivity (NEP) and gross primary productivity (GPP) of alien plant drops by 21.03% overall, with a notable 29.59% reduction during Neap tide. In contrast, native vegetation maintains a more stable productivity profile under the same conditions. Spring tide alleviate the negative impact of high temperatures on the alien vegetation, exhibiting a distinct environmental buffering effect. Photosynthetic photon flux density emerged as a crucial factor driving productivity, yet its effectiveness was moderated by aerodynamic conductance for heat transfer (Ga_h). Through the application of the Michaelis-Menten model, we confirmed that both species maintain similar maximum light utilization efficiencies, yet native vegetation demonstrates greater resilience to thermal stress. Additionally, we observed a 33.82% overestimation in productivity by the vegetation photosynthesis model (VPM) under high temperatures, emphasizing the need to refine how Ga_h impacts are integrated, particularly when comparing the resilience of native and alien species. We emphasize necessity of incorporating canopy structure factors into ecological models and underscore the importance of maintaining tidal dynamics for coastal wetland management.

PERFIL EPIDEMIOLÓGICO DE PACIENTES SUBMETIDOS A PROCEDIMENTO CIRÚRGICO ELETIVO EM UM HOSPITAL DE SANTOS-SP PARA TRATAMENTO DE CÂNCER COLORRETAL

Introduction:Colorectal cancer (CRC), a disease that affects segments of the large intestine, is one of the most common neoplasms and has a great impact on morbidity and mortality worldwide.Objective: To analyze the profile of patients with colorectal cancer (CRC), which is a malignant neoplasm that affects the large intestine and/or rectum. The study patients were admitted to elective hospital treatment at the hospital in a coastal city in Brazil (Santos - SP) from 2021 to 2023. Methods: Cross-sectional study with a quantitative approach, based on the analyzes analyzed in the medical records. Results: The patients in the present study with colon and rectal cancer surgically treated during the period had a mean age of 63.3 ± years, 50% female and 50% male. study. The average length of stay was 6.5 ± days, of these patients, those who stayed in the ICU had an average time of 3.52 ± days. Conclusion: From this study, it was possible to outline the epidemiological profile of the evaluated patients, with this data consistent with that available in the current literature. Furthermore, it was possible to determine the most common histological type and analyze the duration of immediate postoperative hospitalization in both the ward and the intensive care unit. In this way, strategies for improvement, ranging from the surgical approach to these patients to intra-hospital postoperative care, can be established.