Currently, the research on wind-induced response of membrane structures focuses on the normal wind field, and there is little research on typhoon with greater disaster. In this paper, the wind-induced response of saddle membrane structures under typhoon is studied by numerical simulation. Firstly, the wind field information of typhoon is simulated according to the Weather Research and Forecasting model, and the information is used as the inlet boundary condition of Computational Fluid Dynamics. The vibration modal analysis is carried out, considering the influence of wind field intensity, wind direction angle, rise-span ratio, and pretension on the displacement of the membrane. The results show that the probability density curve of wind-induced response has a certain skewness. The saddle membrane structure has the largest vibration amplitude of the membrane at 0° wind direction angle, and the most unfavorable wind pressure value of the membrane is negative. In reducing the displacement of the membrane, the effect of reducing the wind-induced vibration response by increasing the rise-span ratio of the structure is better than that of the pretension. This paper reveals that the law of wind-induced response can provide a theoretical basis for the design of membrane structures against typhoons.