Graphene Oxide Field Effect Research Articles

Reduced graphene oxide field-effect transistor for label-free femtomolar protein detection

We report reduced graphene oxide field effect transistor (R-GO FET) biosensor for label-free ultrasensitive detection of a prostate cancer biomarker, prostate specific antigen/α1-antichymotrypsin (PSA-ACT) complex. The R-GO channel in the device was formed by reduction of graphene oxide nanosheets networked by a self-assembly process. Immunoreaction of PSA-ACT complexes with PSA monoclonal antibodies on the R-GO channel surface caused a linear response in the shift of the gate voltage, Vg,min, where the minimum conductivity occurs. The R-GO FET can detect protein-protein interactions down to femtomolar level with a dynamic range over 6-orders of magnitude in the Vg,min shift as a sensitivity parameter. High association constants of 3.2nM−1 and 4.2nM−1 were obtained for the pH 6.2 and pH 7.4 analyte solutions, respectively. The R-GO FET biosensor showed a high specificity to other cancer biomarker in the phosphate buffered saline solutions as well as in the human serum.

PH Sensing Characteristics and Biosensing Application of Solution-Gated Reduced Graphene Oxide Field-Effect Transistors

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Reduced Graphene Oxide Field Effect Transistor for Multi-Stimuli Responsiveness

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Dual n-type doped reduced graphene oxide field effect transistors controlled by semiconductor nanocrystals

Here, we demonstrate a rapid and simple method for doping a reduced graphene oxide (rGO) field effect transistor (FET) with nanocrystals to produce dual n-type behavior with light and bias voltage. This convenient method promises industrial level doping of graphene transistors.

Real‐Time DNA Detection Using Reduced Graphene Oxide Field Effect Transistors

DNA sensing: Single strands of DNA are covalently attached to nanometer-thick layers of reduced graphene oxide, forming an FET device capable of sensitive, label-free detection of complementary DNA hybridization.

High yield fabrication of chemically reduced graphene oxide field effect transistors bydielectrophoresis

We demonstrate high yield fabrication of field effect transistors (FET) using chemicallyreduced graphene oxide (RGO) sheets. The RGO sheets suspended in water were assembledbetween prefabricated gold source and drain electrodes using ac dielectrophoresis. With theapplication of a backgate voltage, 60% of the devices showed p-type FET behavior, whilethe remaining 40% showed ambipolar behavior. After mild thermal annealing at200 °C, all ambipolar RGO FET remained ambipolar with increased hole andelectron mobility, while 60% of the p-type RGO devices were transformed toambipolar. The maximum hole and electron mobilities of the devices were 4.0 and1.5 cm2 V − 1 s − 1 respectively. High yield assembly of chemically derived RGO FET will have significantimpact in scaled up fabrication of graphene based nanoelectronic devices.

Characteristics of MF membranes

Since brain natriuretic peptide (BNP) has become internationally recognized biomarkers in the diagnosis and prognosis of heart failure (HF), it is highly desirable to search for a novel sensing tool for detecting the patient's BNP level at the early stage. Here we report a platinum nanoparticles (PtNPs)-decorated reduced graphene oxide (rGO) field effect transistor (FET) biosensor coupled with a microfilter system for label-free and highly sensitive detection of BNP in whole blood. The PtNPs-decorated rGO FET sensor was obtained by drop-casting rGO onto the pre-fabricated FET chip and subsequently assembling PtNPs on the graphene surface. After anti-BNP was bound to the PtNPs surface, BNP was successfully detected by the anti-BNP immobilized FET biosensor. It was found that the developed FET biosensor was able to achieve a low detection limitation of 100 fM. Moreover, BNP was successfully detected in human whole blood sample treated by a custom-made microfilter, suggesting the sensor's capability of working in a complex sample matrix. The developed FET biosensor provides a new sensing platform for protein detection, showing its potential applications in clinic sample.