Graphene-coated Surface Plasmon Resonance Research Articles

Detection of Leptospirosis Bacteria in Rodent Urine by Surface Plasmon Resonance Sensor Using Graphene

In this paper, a graphene-coated surface plasmon resonance sensor is designed for the examination of Rodent urine which is responsible for Leptospirosis bacteria. Rodent urine is considered as sensing medium. Graphene surface is activated by phosphate-buffered saline solution for better attachment of Leptospirosis bacteria on its surface. Oliguria and Polyuria are the Rodent urine with high and low concentrations of Leptospirosis bacteria, respectively. The transfer matrix method is used for the formulation of reflection intensity of p-polarized light. The reflectance curves for angular interrogation are plotted and the results are obtained in terms of sensitivity, detection accuracy, and quality factor. The significantly high sensitivity and detection accuracy for Oliguria distinguishes it from Polyuria having lower sensitivity.

A novel graphene coated surface plasmon resonance biosensor with tungsten disulfide (WS2) for sensing DNA hybridization

In this paper, we propose a rigorous configuration of graphene coated surface plasmon resonance (SPR) sensor with Tungsten Disulfide (WS2) for sensing DNA hybridization. The present configuration is consisted of prism (SF10 glass), Gold (Au), WS2- graphene and sensing medium. We perform the performance parameters of the proposed sensor in terms of sensitivity, detection accuracy and quality factor. Here we report a dramatic enhancement of the overall performance. Addition of graphene layers increase the sensitivity but decrease the other performance parameters. To increase the all performance parameters we add WS2 between metal and graphene layer. Furthermore in this paper, the thickness effect of Gold (Au) is also analyzed. Numerical analysis shows that the variation of SPR angle for mismatched DNA strands is quiet negligible whereas that for complementary DNA strands is considerably countable. Therefore, the proposed biosensor opens a new window towards detection for biomolecular interactions.

Numerical analysis of graphene coated surface plasmon resonance biosensors for biomedical applications

This paper describes the effect of adding graphene layers in prism and planar waveguide based surface plasmon resonance biosensors using angular interrogation mode. The proposed sensors are designed based on graphene material as biomolecular recognition elements (BRE) and the sharp SPR curve of gold (Au). Our calculations show that the proposed graphene in prism and planar waveguide based SPR biosensors have 1+0.40L and 1+0.45L; (where L is the number of graphene layers) times more sensitivity than the conventional SPR biosensor respectively. The enhanced sensitivity is due to increased SPR angle change about 40L% and 45L% by adding graphene layer and using the optical property of graphene. We also investigate the performance of proposed biosensors in terms of sensitivity using graphene sublayers. The compact size, prism and planar waveguide based design, and very high sensitive- these characteristics are expected to make these biosensors preferred choice for biomedical applications, as compared to other contemporary biosensors.

Sensitivity analysis of graphene coated surface plasmon resonance biosensors for biosensing applications

This paper describes the effect of adding graphene layers in prism and planar waveguide based surface plasmon resonance biosensors using angular interrogation mode. The proposed sensors are designed based on graphene material as biomolecular recognition elements (BRE) and the sharp SPR curve of gold (Au)·Our calculations show that the proposed graphene in prism and planar waveguide based SPR biosensors have 1+0.40L and 1+0.45L; (where L is the number of graphene layers) times more sensitivity than the conventional SPR biosensor respectively. The enhanced sensitivity is due to increased SPR angle change about 40L% and 45L% by adding graphene layer and using the optical property of graphene. We also investigate the performance of proposed biosensors in terms of sensitivity using graphene sublayers.

Sensitivity enhancement of graphene coated surface plasmon resonance biosensor

In this paper, a highly sensitive surface plasmon resonance biosensor is presented using angular interrogation. Due to low sensitivity of conventional biosensor, graphene/two-dimensional transition metal are used in surface plasmon resonance biosensor to improve the sensitivity. Here, we propose a seven layer model of biosensor which shows by incorporating silicon layer in addition of transition metal dichalcogenides MoS2 and graphene, the sensitivity of the proposed SPR biosensor can be greatly enhanced than the conventional gold film SPR sensors. It is observed that the highest sensitivity can be obtained by optimizing the structure with 8 nm thickness of silicon layer, one layer of MoS2 and one layer of graphene. The highest sensitivity of our proposed sensor is 210°/RIU.

Carbohydrate–Lectin Interaction on Graphene-Coated Surface Plasmon Resonance (SPR) Interfaces

The paper describes the detection of carbohydrate- lectin interaction on graphene-on-metal surface plasmon res- onance (SPR) interfaces. Graphene-coated gold-based SPR interfaces were formed through the transfer of large-area graphene grown by chemical vapor deposition (CVD) on polycrystallineCufoils.Themethodallowed successfultrans- fer of single- and double-layered graphene sheets onto the SPR interfaces in a reproducible manner. Functionalization of the graphene interface with mannose was achieved by simple immersion into a mannose aqueous solution (100 mM), resulting in noncovalent interactions between the aromatic ring structure of graphene and mannose. The utility of the carbohydrate-modified graphene-on-gold interface for the se- lective and sensitive detection of carbohydrate-lectin interac- tions was demonstrated using model lectins from Lens culinaris (LC )a ndTriticum vulgaris (TV). While LC lectin binds specifically to mannopyranoside units, TV lectin has an affinity for N-acetyl glucosamine and sialic acid residues.