Granulomatous Mycosis Fungoides Research Articles

The Crazy-paving Pattern in Granulomatous Mycosis Fungoides

The purpose of this report is to describe a further distinctive cause of crazy-paving pattern on thin-section computed tomography in a patient affected by pulmonary granulomatous mycosis fungoides. It was possible to reconcile the crazy-paving appearance on thin-section computed tomography scan with the histopathologic pattern termed acute fibrinous organizing pneumonia pattern.

Micosis fungoide granulomatosa unilesional

Abstract.—One of the multiple variants of mycosis fungoides is granulomatous mycosis fungoides, a rare form difficult to differenciate histologically from other conditions with granulomatous features.We report the case of a 68-year-old woman with an erythemato- edematous plaque, 5 × 5 cm in size, on the chin; it was unchanged during 12 years. Several biopsies showed the same features.

Granulomatous slack skin or granulomatous mycosis fungoides – a case report.

A 46-year-old man presented with circumscribed inflammatory poikilodermatic lesions of loose skin on the upper arm. Histologic examination disclosed a heavy lymphocytic infiltrate of the whole dermis and the upper part of the subcutaneous fat tissue with a predominant T-helper phenotype and about 10% of Mac 387-positive macrophages and some scattered multinucleated giant cells. Lymphocytic cells were aligned along the epidermal basement membrane and showed focal epidermotropism. In part these cells had multilobular nuclei. The diagnosis of granulomatous mycosis fungoides versus early granulomatous slack skin was made. The patient was treated with a combination of radiotherapy (total dose 36 Gy) and interferon-alpha as a maintenance treatment which resulted in complete remission and disease-free survival of 27 months up to now.

Mycosis fungoides: classic disease and variant presentations.

Mycosis fungoides is a peripheral non-Hodgkin's T-cell neoplastic process, representing the most common type of primary cutaneous malignant lymphoma. Neoplastic lesions classically show skin predilection and characteristic clinical and histologic features in patch, plaque, and tumor stages. In addition, several clinicopathologic variants of mycosis fungoides have been delineated, including poikiloderma atrophicans vasculare (parapsoriasis variegata), Sézary syndrome, granulomatous mycosis fungoides, hypopigmented mycosis fungoides, folliculocentric mycosis fungoides, syringotropic mycosis fungoides, and Woringer Kolopp disease. We will review the salient features of patch, plaque, and tumor stage mycosis fungoides in this article and follow with a discussion of these variant clinicopathologic presentations and of therapeutic modalities.

Granulomatous Mycosis Fungoides with Fatal Small Intestine Involvement: Case Report and Literature Review.

s From The 18Th Colloquium Of The International Society Of Dermatopathology (Isd) And The Austrian Society Of Dermatopathology

Tumour progression in a patient with granulomatous mycosis fungoides

We report a patient with granulomatous mycosis fungoides whose disease transformed into a high grade blast lymphoma with angiocentric features within 12 months of the initial diagnosis. This repudiates previous claims that granulomatous inflammation is protective in cutaneous T-cell lymphoma.

Granulomatous slack skin: A possible precursor of Hodgkin's disease

Granulomatous slack skin (GSS) is a rare lymphoproliferative disorder that is an unusual variant of cutaneous T-cell lymphoma (CTCL).l It is characterized by the progressive laxity of affected skin, with predilection for flexural areas.‘, 3 The disease has a marked male predominance, with age at onset typically ranging from adolescence to middle age! Although histologically similar to granulomatous mycosis fungoides (MF), GSS can be distinguished from MF by both clinical and histologic criteria? Approximately one third of the reported patients with GSS have subsequently had Hodgkin’s disease.4 We describe a patient with GSS in whom Hodgkin’s disease developed approximately 11 years after the initial appearance of his skin lesions.

Granulomatous Mycosis Fungoides

Granulomatous mycosis fungoides is a rare form of mycosis fungoides with controversial histogenesis. Early reports seemed to indicate a favorable prognosis for these patients. We report two cases of granulomatous mycosis fungoides, both of which had other unusual clinical features. The cases were studied with routine light microscopy, immunohistochemistry, electron microscopy, and gene probe studies. Despite some clinical and histopathologic similarities, the results of the immunohistochemical and molecular biologic studies were diverse. These results suggest that granulomatous mycosis fungoides does not define a single subset of cases, immunophenotypically or biologically.

Granulomatous variants of cutaneous T-cell lymphoma. The histopathology of granulomatous mycosis fungoides and granulomatous slack skin.

Granulomatous mycosis fungoides is an unusual histologic variant of mycosis fungoides, a condition that is ordinarily indolent. Granulomatous slack skin, like granulomatous mycosis fungoides, shows epidermotropism, granulomatous inflammation, a clonal T-helper cell population, and progression to systemic lymphoma in some cases. Unlike granulomatous mycosis fungoides, it is characterized clinically by bulky, pendulous skin folds. The similarities between the two conditions prompted us to compare the histologic features. We reviewed 24 biopsies from 10 patients with granulomatous mycosis fungoides. These showed several distinct histologic patterns, including three cases that mimicked granuloma annulare. We also reviewed biopsy specimens from four patients with granulomatous slack skin. These specimens had a more stereotypic appearance, with permeation of the entire dermis and subcutis by lymphocytes, marked epidermotropism, and a more even distribution of granulomas and giant cells within the infiltrate. Biopsies of fully developed lesions of granulomatous slack skin showed elastolysis involving the full thickness of the dermis--a feature not seen in any of our granulomatous mycosis fungoides cases. Biopsy specimens from granulomatous mycosis fungoides and granulomatous slack skin may be mistaken for nonneoplastic granulomatous dermatitides, but they can usually be distinguished from these by the presence of epidermotropism or atypical lymphocytes. Because several of our patients with granulomatous mycosis fungoides died after courses of unremarkable length, it seems unlikely that the presence of granulomas is invariably correlated with a more benign course than nongranulomatous mycosis fungoides.

Lymphomatoid Papulosis Associated With Plaque-Stage and Granulomatous Mycosis Fungoides

A 47-year-old black man had typical papulonodular lesions of lymphomatoid papulosis (LyP) with concurrent plaque-stage mycosis fungoides (MF). Both diagnoses were confirmed histologically. This supports the concept that LyP is part of the spectrum of cutaneous T-cell lymphoproliferative disorders. The patient also had a large nodule and a deeply infiltrated plaque, each of which exhibited a deep granulomatous reaction. These were interpreted as representing granulomatous MF. Clinically, there was an evolution from a predominance of LyP lesions to a predominance of MF plaques. Topical carmustine therapy resulted in a substantial decrease in the number and size of both LyP and MF lesions. Both lesion types involuted with hypopigmentation.

Lymphomatoid papulosis associated with plaque-stage and granulomatous mycosis fungoides

Lymphomatoid papulosis associated with plaque-stage and granulomatous mycosis fungoides

Granulomatous mycosis fungoides

This is a 14-year follow-up of a patient with granulomatous mycosis fungoides. The patient has had nodular lesions of mycosis fungoides for more than 30 years, an unusually long survival for the nodular form of the disease that is often quickly fatal. The role of the granulomatous inflammatory response in his survival is speculated upon.