Granites play a crucial role in the Earth's thermal regime and its evolution. Radiogenic heat production (RHP) by the decay of radioactive elements (U, Th, K) in granites is a significant parameter in estimating the thermal structure of the lithosphere. RHP variability of granites with their emplacement ages could provide insights for thermal modeling in different geological epochs. An aggregated RHP from 2877 globally-distributed granitic samples of continental crust are analyzed for this study; these sample cover the entire geological history. The average bulk RHP in all types of granitic rocks of all ages is 2.92 ± 1.86 μW/m3. The RHP tends to increase gradually with progressively younger geologic emplacement age, based on a statistical analysis of the data. However, the youngest granites do not necessarily have the highest RHP. The mean RHP in 181 representative Cenozoic Himalayan leucogranites— which are the youngest granites found on Earth, is as low as 1.84 μW/m3. This is probably related to the initial conditions of magma formation, magmatic source material, and differentiation processes in the Himalayan–Tibetan plateau. By correcting the decay factor, variations of the RHP in the emplaced granitic rocks are obtained, indicating the changing levels of heat production and different thermal regimes on Earth in various geological epochs. The highest RHP in granitic rocks emplaced in the Archean and Early Proterozoic corresponds to two global-scale collisional events during supercontinent cycles, at 2.7 and 1.9 Ga respectively. RHPs of granites can be an important indicator in the study of Earth's thermal regime and its evolution.