The cores of transformers and reactors are subjected to mechanical stresses during both manufacturing and operation, these stresses exert an influence on the magnetic properties of the cores. Additionally, there exists rotating magnetic flux within the cores during operation. Therefore, it is necessary to further consider the magnetic properties of grain-oriented silicon steel sheet in the direction perpendicular to the rolling direction. To delve deeply into the comprehensive magnetic properties of grain-oriented silicon steel sheet under mechanical stress, with a particular focus on both the rolling direction and the direction perpendicular to it, this paper presents the establishment of a comprehensive magnetic properties measurement platform for grain-oriented silicon steel sheet that possesses stress adjustment capabilities. Through meticulous measurements, the impacts of tensile and compressive stresses on the magnetic hysteresis loops, B-H curves, relative permeability, magnetostriction, and iron loss characteristics of grain-oriented silicon steel sheet in both the rolling direction and the perpendicular direction were obtained and analyzed. The measurement results and subsequent analysis indicate that tensile and compressive stresses exert an influence on the magnetization characteristics of grain-oriented silicon steel sheet. Moreover, the extent of this influence varies between the rolling direction and the direction perpendicular to rolling for both tensile and compressive stresses; In the rolling direction, compressive stress promotes the magnetostriction of the grain-oriented silicon steels, while tensile stress inhibits it. In the direction perpendicular to rolling, both tensile and compressive stresses inhibit the magnetostriction of the grain-oriented silicon steels, with tensile stress exerting a greater inhibitory effect; Tensile stress acts to reduce the iron loss of grain-oriented silicon steels, whereas compressive stress increases it, this pattern is consistently observed in both the rolling direction and the direction perpendicular to rolling.