Grafting Amino Research Articles

Preparation and oxidative desulfurization performances of modified SBA-15 supported polyacid metal oxolates

In this study, eight composite catalysts were prepared by loading (CTAB)3H3[PW9V3O40] (active components) onto amino-functionalized mesoporous titanium silicate Ti-SBA-15(supports). In order to study the effects of different Ti contents and different active components on the catalytic performances of the catalysts, 30 %(CTAB)3H3[PW9V3O40]/NH2–Ti-SBA-X (X = 0, 25, 50, 75, 100) and X%(CTAB)3H3[PW9V3O40]/NH2–Ti-SBA-50 (X = 20, 40, 50) were obtained and characterized. The oxidative desulfurization performances of the composite catalysts were explored. It was found that catalyst 40 %(CTAB)3H3[PW9V3O40]/NH2–Ti-SBA-50 exhibits the optimal oxidative desulfurization performance. This is because the incorporation of SBA-15 with an appropriate amount of Ti (n(Si)/n(Ti) = 50) can improve the acidity and stability of mesoporous silica. The successful substitution of CTAB (n(CTAB)/n(H6PW9V3O40) = 3) in the active component can reduce the mass transfer resistance and speed up the reaction rate. 3-Aminopropyltriethyl silane (APTES) acts as a silane coupling agent to graft amino groups onto mesoporous molecular sieve SBA-15, which can enhance the interaction between heteropolyacids and carriers. Under the synergistic effect of the active component and the support, the total removal rate of the optimal catalyst with a total concentration of 1000 ppm sulfur compounds in the simulated fuel was 94.44 %. After four cycles, the total desulfurization rate of the catalyst can reach 91.28 %.

Exploring surface silanols in mesoporous Na-LTA zeolite to enhance its catalytic activity in knoevenagel condensation by grafting amino groups

Mesoporous Na-LTA zeolite was synthesized using the surfactant templating method with the organosilane surfactant [3-(trimethoxysilyl)propyl] octadecyldimethylammonium chloride (TPOAC). The formation of mesopores not only improved the accessibility of the basic catalytic sites but also led to the formation of isolated external silanols. These silanols were used to anchor propylamine groups by reacting with 3-aminopropyltrimethoxysilane (APTMS). The incorporation of propylamine groups in the mesoporous Na-LTA improved its catalytic activity in the Knoevenagel condensation reaction by 40 % due to the presence of extra basic catalytic sites from amino groups. The combination of mesopore generation and functionalization is an efficient strategy for enhancing the performance of Na-LTA zeolite in this reaction.

Novel Sprayable Antioxidative Dressing Based on Fullerene and Curdlan for Accelerating Chronic Wound Healing.

The effective treatment of chronic wounds represents a critical global medical challenge demanding urgent attention. Persistent inflammation, driven by an excess of reactive oxygen radicals, sets in motion a detrimental cycle leading to chronic wounds and impeding the natural healing process. This study develops a sprayable wound dressing by covalently grafting amino fullerene to carboxymethylated curdlan (CMC-C). This novel dressing exhibits excellent biocompatibility, antioxidant, and reactive oxygen species scavenging properties. Furthermore, it demonstrates a targeted affinity for HEK-a cells, efficiently reducing the inflammatory response while promoting cell proliferation and migration in vitro. Moreover, the animal experiment investigations reveal that CMC-C significantly accelerates chronic wounds healing by regulating the inflammatory process, promoting collagen deposition, and improving vascularization. These results demonstrate the potential of the sprayable dressing (CMC-C) in curing the healing of chronic wounds through the modulation of the inflammatory microenvironment. Overall, the sprayable hydrogel dressing based on water-soluble derivative of fullerene and curdlan emerges as a potential approach for clinical applications in the treatment of chronic wounds.

Development of functionalized poly(lactide) films with chitosan via SI-SARA ATRP as scaffolds for neuronal cell growth

Polylactic acid (PLA), a polymer derived from renewable resources, is gaining increasing attention in the development of biomedical devices due to its cost-effectiveness, low immunogenicity, and biodegradability. However, its inherent hydrophobicity remains a problem, leading to poor cell adhesion features. On this basis, the aim of this work was to develop a method for functionalizing the surface of PLA films with a biopolymer, chitosan (CH), which was proved to be a material with intrinsic cell adhesive properties, but whose mechanical properties are insufficient to be used alone. The combination of the two polymers, PLA as a bulk scaffold and CH as a coating, could be a promising combination to develop a scaffold for cell growth. The modification of PLA films involved several steps: aminolysis followed by bromination to graft amino and then bromide groups, poly(glycidyl methacrylate) (PGMA) grafting by surface-initiated supplemental activator and reducing agent atom transfer radical polymerization (SI-SARA ATRP) and finally the CH grafting. To prove the effective adhesive properties, conjugated and non-conjugated films were tested in vitro as substrates for neuronal cell growth using differentiated neurons from human induced pluripotent stem cells. The results demonstrated enhanced cell growth in the presence of CH.

Nanostructures Originated from Grafting Amino Group Containing Biomolecules on Graphene Oxide

AbstractWith the aim of obtaining new composites from graphene oxide for a new biological application, it urged us to select some amine containing molecules namely purpald, mafenide acetate and fluvoxamine for grafting that was resulted to the formation of purpald‐grafted graphene oxide, mafenide‐grafted graphene oxide and fluvoxamine‐grafted graphene oxide, respectively. These novel nanocomposites were evaluated by X‐ray photoelectron spectroscopy, Transmission electron microscopy, Field emission scanning electron microscopy,Dynamic light scattering, Zeta potential, X‐ray diffraction, Thermogravimetric analysis, Raman, and Fourier‐transform infrared. The findings demonstrated that the grafting was done satisfactorily. X‐ray photoelectron spectroscopy analysis revealed that the peaks seen at 286.07, 285.79, and 285.49 eV corresponded to the formation of carbon‐nitrogen bonds between the amine groups of purpald, mafenide acetate, and fluvoxamine, respectively, and the functionalized oxygen groups present on the surface of graphene oxide. In this study, three nanocomposites were subjected to practical testing in close proximity to human breast cancer cells. After a period of 24 hours, it was shown that purpald‐grafted graphene oxide demonstrated more cellular toxicity compared to the other nanocomposites.

Microwave synthesis of amino-functionalized MCM-41 from coal gasification fine slag for efficient bidirectional adsorption of anionic and cationic dyes

Coal based solid waste has been recognized as a sustainable raw material for the preparation of high added value materials for wastewater treatment. In this paper, a preparation route was designed for the rapid, efficient, and low-cost preparation of MCM-41 zeolite using coal gasification fine slag as raw material. Functionalization modification of MCM-41 was carried out by grafting amino groups on its surface to improve its application performance. Moreover, the prepared functionalized material is used for bidirectional adsorption of anionic and cationic dyes. The experimental results indicate that MCM-41 zeolite with highly ordered pore structure was rapidly prepared using the advantages of fast heating and strong permeability of microwave synthesis method, with a specific surface area of up to 862.03 m2/g. Amine functionalized MCM-41 exhibits strong adsorption capacity for both cationic and anionic dyes, with maximum adsorption capacities for methylene blue and Congo red being 292.40 mg/g and 354.61 mg/g, respectively. The study of adsorption kinetics and adsorption mechanism indicate that the adsorption process is mainly controlled through chemical adsorption, including electrostatic attraction, hydrogen bonding, and π-π interactions. The results of this study will provide useful references for the use of coal based solid waste to prepare functional materials for the treatment of organic wastewater.

Glutamic-acid grafted hyaluronic acid inhibits inflammatory factors via fibroblast and skin model tests.

Excessive inflammation may cause tissue damage and disrupt the function of the skin barrier. Hyaluronic acid (HA), an endogenous component, was found to regulate multiple inflammatory factors for skin health. This work aims to further enhance its efficacy by grafting amino acid onto its molecule. Glutamic acid (Glu) was selected as the ligand to react with low-molecular-weight HA. Fibroblast tests and a 3D skin model were used to investigate the anti-inflammation efficacy of HA-Glu. For IL-1α, IL-6 and TNF-α, the grafted compound presents stronger inhibition ability versus native HA. Moreover, HA-Glu could promote the repair of damaged skin by improving the compactness of the stratum corneum and increasing the thickness of the living cell layer. The application of HA-Glu compound in skin care formulas would be effective to alleviate inflammation-induced skin symptoms and skin aging.

A moist-electric generator based on oxidized and aminated regenerated cellulose

Moist-electric generation has been more focused in recent years, which is an emerging sustainable energy harvesting technology. Moist-electric generator (MEG) is a prospective energy harvesting device that collects energy only from humidity. While the existed researches focused on the ionic wood, cellulose nanofibril and cellulose acetate, this work pays attention to the oxidized regenerated cellulose (ORC) and aminated regenerated cellulose (ARC) prepared by urea/NaOH/water system from pulp, which has excellent hydrophilicity and abundant active sites attributing to the abundant functional groups and three-dimension porous structure. Its asymmetric active electrode and asymmetric ORC and ARC structure cause a humidity gradient between the two electrodes as exposed in a humidity environment, which produce potential difference under the ion concentration gradient for the directional transport of protons derived from the ionization effect, thus generating an electric current in external circuit. Of which, 12-ORC-MEG can generate an open-circuit voltage of 1.07 V at 85%RH humidity. 5-ARC-MEG can produce the output voltage as high as 4.20 V for the brought more isoelectric points by grafting amino, which is about 4 times than that of 12-ORC-MEG. The MEG as a sensor and generator can generate a certain output voltage in contact with sweaty fingers or intermittent fog. Just one 5-ARC-MEG can power micro-electronic devices, such as LED lamp and watch. This work develops a simple, inexpensive, and green MEG with renewable cellulose material that can generate sustainable moist-electric conversion from ambient humidity. It has great potential in green energy and opens up new possibilities for portable electronic products.

Competitive recovery of copper ions using ethyl acetoacetate modified chitosan/organo-functionalized alginate hydrogel beads: kinetics and isothermal sorption studies

Surface functionalization of chitosan using some chelating ligands not only improves sorption capacity but also induces selectivity into the biopolymer. The current study is based on the facile synthesis of ethyl acetoacetate modified chitosan and surface-functionalized alginate composite beads (EAA-MCSA). Chemical modification of sodium alginate was carried out to graft amino thiocarbamate moiety (-OCSNHNH2) to entrench selectivity and specificity across the linear chains of preliminary polysaccharide. Biosorbent (EAA-MCSA) was thoroughly characterized by FT-IR and SEM analysis and employed in the form of composite hydrogel beads for competitive Cu(II) recovery. Newly grafted aminothiocarbamate (-OCSNHNH2) and 1,3-dicarbonyl moieties (-COCH2CO-) are supposed to act as potential chelating sites for enhanced Cu(II) sorption. Kinetic data could be well depicted using pseudo-second order rate law (R2 = 0.99, qexp≈qe,th = 85.25 mg/g, k2 = 0.45–1.17 ×10−2 g/mg.min−1) and sorption data was found in close agreement with Langmuir adsorption isotherm (R2 = 0.99, qm= 390.21 mg/g at 298 K and pH = 6.0, KL= 0.44–0.49 ×10−2 L/mg). The ΔG° values (−20.75, −21.10, −21.30 and −21.50 kJ/mol) and positive ΔH° (−7.63 kJ/mol) designated the sorption process as spontaneous and exothermic, respectively. Hence, EAA-MCSA could be a better sorbent for adsorptive remediation of Cu(II) from dilute effluents.

Methylthiazole Schiff base functionalized SBA-15 for high-performance Pb(Ⅱ) capture and separation

Selective recovery of Pb(II) from effluent reduces its toxic impact on environment and benefits for saving non-renewable lead resources. To capture and separate Pb(II), a kind of methylthiazole Schiff base modified mesoporous silica, denoted as MTCI-SBA-15, was fabricated via grafting amino groups onto SBA-15 which was followed by Schiff condensation with 4-methylthiazole-5-carboxaldehyde. A variety of characteristic methods monitored the evolution of the modified adsorbent. Pb(II) uptake to MTCI-SBA-15 was studied in batch mode concerning pH, contact time, initial concentration, temperature, coexisting metallic ions, etc. Kinetic analyses revealed that the pseudo-second-order model was suitable for describing adsorption process. The adsorption isotherms were well represented by the Langmuir model. The thermodynamic study confirmed that the sorption was spontaneous and endothermic. The maximal load ability of MTCI-SBA-15 (283 mg g−1) for Pb(II) outperformed that of most modified mesoporous silica adsorbents. Moreover, Pb(II) removal efficiency higher than 99% can be reached with a low initial concentration (<50 mg L−1). Testing on the effects of competing ions suggested that MTCI-SBA-15 exhibited a desirable selectivity for Pb(II). Further, MTCI-SBA-15 was recyclable, retaining 93.1% of the adsorption capacity after five successive cycles. Mechanisms investigation indicated that the imine N atom on the Schiff base and the S atom on the 4-methylthiazole ring played a synergistic role during the adsorption process for Pb(II). The MTCI-SBA-15 showed excellent application potential for Pb(II) capture and separation.

A Continuous-Flow Microreactor for Knoevenagel Condensation of Ethyl Cyanoacetate with Benzaldehyde: The Effect of Grafted Amino Groups on Catalytic Activity.

Ethyl α-cyanocinnamate was synthesized in the Knoevenagel condensation of benzaldehyde and ethyl cyanoacetate in flow monolithic microreactor of 0.63 cm3 volume. The catalytically active core was made of silica monolith modified with various amine group precursors. Structural properties of the support, surface density of NHx groups, and catalytic activity were investigated. It was found that the poly- or di-amine groups attached to the silica surface appeared to be more effective than the aminopropyl groups. Microreactors grafted with diamine functional groups, accompanied by hydrophobic methyl groups, showed the highest activity and stability. It was proved that the decisive role on the activity of catalysts was exerted by the presence of primary amines in diamine chain. The reaction conditions were optimized and it was found that almost full substrate conversion could be achieved in 6 min at 50 °C in the microreactor with low concentration of diamine groups equal to 0.33 mmol g-1 .

Grafting amino groups to enhance the adsorption of antimonate by MIL-100(Fe) for from natural water: Performance and mechanism

MIL-100(Fe) was modified by amino groups (MIL-100(Fe)-NH2) to enhance the removal of antimonate (Sb(V)) with low concentration (50−200 μg/L) from natural water through batch adsorption experiments. With the initial Sb(V) concentration up to 200 μg/L, the residual Sb(V) concentration after treated by MIL-100(Fe)-NH2 was only 3.52 ± 0.131 μg/L, lower than the drinking water standards (5 μg/L) in China, while that was much higher (94.2 ± 3.52 μg/L) after pristine MIL-100(Fe) treatment. Based on results of XPS analysis, and adsorption kinetics and isotherms, we concluded that Sb(V) substituted the terminal −OH groups of MIL-100(Fe) to form inner-sphere complexes by coordination reactions with Fe nodes and be adsorbed by hydrogen bonding as well. The grafted amino groups (−NH2) adsorbed Sb(V) by hydrogen bonding and facilitated the coordination reactions between Sb(V) and Fe nodes. The higher KL value (0.0116 ± 0.00,118 L/μg) obtained by fitting with the Langmuir isotherm model, while that of unmodified MIL-100(Fe) was 4.74 × 10−4 ± 5.85 × 10−5 L/μg, also confirmed that the −NH2 groups greatly enhanced the affinity between MIL-100(Fe) and Sb(V). Furthermore, MIL-100(Fe)-NH2 still worked nicely in a wide pH range (2 − 12), with varied ionic strength (0.05 µmol/L−1.5 mol/L), coexisting ions (CO32−, NO3−, SO42−, Cl−, H2PO4−), and even in the real water bodies. Additionally, MIL-100(Fe)-NH2 exhibited good reusability and low Fe leaching (99.92 μg/L). We hope MIL-100(Fe)-NH2 become a candidate for effective removal of Sb(V), even other heavy metals from natural waterbodies.

Enhanced biocompatibility and osteogenic ability on amino-modified polyetheretherketone

Polyetheretherketone (PEEK) is a potential implant material for dental application due to its excellent mechanical properties and low elasticity modulus. However, its biological inertia results in weak osseointegration between implants and bone tissue, which limited its clinical application. In this study, amino groups were covalently grafted on the PEEK surface using a simple facile self-assembly method to address its poor osteogenic ability. The surface characterization, cell adhesion, proliferation and osteogenic differentiation of MC3T3-E1 cells on bare PEEK and amino-modified PEEK (PEEK-APTES) were studied. After grafting amino groups onto the PEEK, the surface morphology changed, the contact angle decreased significantly. The PEEK-APTES showed boosted cell adhesion, proliferation, alkaline phosphate (ALP) activity, extracellular matrix (ECM) mineralization, and expression of osteogenic genes in MC3T3-E1 cells. These findings suggested that amino modification significantly improved the biocompatibility and osteogenic ability of PEEK in vitro.

Enhanced and efficient removal of heavy metals by amino-decorated membranes in coordination with multi-function

A multi-functional MA/GMA@PVDF membrane with abundant amino groups was first prepared by grafting the intermediate with an epoxy group from glycidyl methacrylate (GMA) into a defluorinated polyvinylidene fluoride (PVDF) and subsequently conducting an ammonifying process with melamine. The highest pure water flux of the selected 0.2 %-MA/GMA@PVDF was up to 562 L/(m2·h), with a high flux recovery ratio of 97.7 %, indicating excellent antifouling performance. Cu(II) concentration in the treatment volume of 47.44 L/m2 met the discharge limitation of 0.5 mg/L, which was more than 5.3 times that of the PVDF membrane. The obvious enhancement was mainly attributed to the grafted amino groups, which could coordinate with Cu(II) with the lone-pair electrons. Moreover, inorganic salts and organic matter could improve 0.2 %-MA/GMA@PVDF rejection performance in mixed systems. Among them, NaNO3 could increase the effective treatment volume to 55.12 L/m2 by charge shielding and compression double layer interaction owing to the unique property of amino groups. The maximum removal of Cu(II) by citric acid was increased by 48.63 % by the complexation of NH2/NH groups. Thus, the multi-functional membrane decorated with amino groups shows great potential as a promising material to efficiently remove heavy metals from complex wastewater.

Synergistic Effect between CO2 Chemisorption Using Amino-Modified Carbon Nitride and Epoxide Activation by High-Energy Electrons for Plasmon-Assisted Synthesis of Cyclic Carbonates.

Photocatalytic CO2 cycloaddition is a promising approach for CO2 value-added processes. However, the efficiency of plasmon-assisted CO2 cycloaddition still needs to be improved and the reaction mechanism is unclear. Herein, g-C3N4/Ag (ACN-Ag) hybrids exhibited superior activity of CO2 cycloaddition by coupling a semiconductor into the plasmonic system, in which the ACN grafting amino group by the formation of carbon vacancies can enhance CO2 chemisorption; meanwhile, photo-generated electrons from ACN transfer to Ag to form high-energy electrons, which can activate propylene oxide, accelerating the ring-opening step. Importantly, photo-generated electron injection from ACN to Ag and the interaction between Ag nanoparticles and ACN were confirmed by single-particle photoluminescence spectroscopy. The wavelength-dependent activity demonstrated that the plasmon excitation is crucial for the reaction. Moreover, in situ single-particle PL quenching caused by propylene oxide and in situ electron paramagnetic resonance verified the activation of propylene oxide by ACN-Ag. This work is conducive to an in-depth understanding of the mechanism of CO2 cycloaddition at the single-particle level and provides guidance for the organic synthesis.

Amino-grafting pre-functionalization of terephthalic acid by impulse dielectric-barrier discharge (DBD) plasma for amino-based Metal-Organic Frameworks (MOFs)

The pre-functionalization of organic ligands before MOFs synthesis has been widely carried out via wet-chemical methods. A possible novel route to perform the pre-functionalization of MOFs’ organic ligands is to graft amino groups on the ligand by means of plasma treatments. In this study, a NH3 impulse dielectric-barrier discharge plasma treatment is used to investigate the efficiency of the pre-functionalization of terephthalic acid. For this purpose, plasma diagnostics is coupled with material characterizations to identify the main reactive plasma species involved in the ligand functionalization. The presence of NH radicals in the plasma phase together with structural modification evidence the effect of the plasma treatment. Chemical analyses of the treated material confirm the presence of nitrogen in the treated sample and prove that the grafting of the amino group occurs at the functional carboxyl group (-COOH) of terephthalic acid, by substituting the C–OH bond by C–NH2 bond. All these results indicate successful modification of terephthalic acid by grafting amino groups thanks to the plasma treatment.

Study on amino-directed modification of oil sludge-derived carbon and its adsorption behavior of bisphenol A in water

In order to remove bisphenol A (BPA) in wastewater, this paper reported an amino-functionalized oily sludge-derived carbon (GP-H-OSC) obtained by grafting amino groups using oily sludge as a precursor, which could quickly adsorb BPA in the wastewater. The adsorption results showed that the grafting modification method was more likely to form effective adsorption sites on the surface than the impregnation modification. FT-IR and Boehm titration results indicated that the oxidation modification strategy was beneficial in generating more carboxyl groups on the surface of the oily sludge-derived carbon, which could provide intermediate connection groups for the subsequent grafting. The SEM and BET results revealed that the polyethyleneimine (PEI) would form a dense mesoporous structure on the surface during the grafting process, which was conducive to the transport of pollutants. The adsorption process of BPA by GP-H-OSC conformed to the pseudo-second-order kinetic model and the Langmuir isotherm model. The maximum extent of BPA adsorption was 393.2 mg/g based on the Langmuir isotherm model. Based on the analysis of FT-IR and XPS, GP-H-OSC mainly trapped BPA in water through the formation of hydrogen bonds between the functional amino groups on the surface and the hydroxyl groups on BPA. Moreover, primary amines were more likely to form hydrogen bonds with hydroxyl groups on BPA than imines. The removal rate of GP-H-OSC for low concentration BPA wastewater could reach 95% within 1 h, and it still had strong adsorption performance after recycling experiments. In summary, it was feasible to graft PEI on the surface of sludge-derived carbon, and the obtained amino-functionalized carbon material could adsorb BPA quickly and efficiently, showing great potential in practical wastewater treatment.

Dynamic Amino Acid Side-Chains Grafting on Folded Peptide Backbone.

An efficient strategy for the synthesis of large libraries of conformationally defined peptides is reported, using dynamic combinatorial chemistry as a tool to graft amino acid side chains on a well-ordered 3D (3-dimension) peptide backbone. Combining rationally designed scaffolds with combinatorial side chains selection represents an alternative method to access peptide libraries for structures that are not genetically encodable. This method would allow a breakthrough for the discovery of protein mimetic for unconventional targets for which little is known.

Design of hierarchical self-assembly 2D silica and their derivative catalysts with accessible open transport channels for boosting oxidative-adsorptive desulfurization in fuel oil

The design and synthesis of hierarchical self-assembled 2D-channel silica (2D-CS) with mesoscopicshape control and developing of their application in catalysis has remained a challenge. Herein, we fabricated a series of 2D-CSx materials through the hierarchical self-assembly of curved lamellar micelles along with their derivative 2D channel catalysts (2D-CSx-NH2-HPW) by grafting amino groups and immobilizing phosphotungstic acid. These catalysts exhibit highly effective oxidative-adsorptive desulfurization (OADS) performance owing to their accessible open-transport channels. A novel theory that the stacking of curved lamellar micelles is similar to that of wrinkled-papers was proposed to explain the hierarchical self-assembly mechanism of the 2D-CS materials, which follows the “short-range order, long-range disorder” rule. Systematic characterizations and experiments indicated that the size and specific surface area of 2D-channel catalysts jointly determine their OADS performance. Most importantly, the 2D-channel catalysts show the highest removal efficiency of DBT when compared with 0D and 1D materials, which was ascribed to their facilitation of molecular diffusion owing to their accessible open-transport channels. The optimal 2D-channel catalysts (2D-CS4-NH2-HPW) exhibited excellent desulfurization performance despite omitting the extraction step, and the removal efficiency of DBT reached 99.72% in 5 min at 60 °C, much faster than previously reported mesoporous-catalyst-supported heteropoly acids. In addition, the OADS activity of typical sulfur compounds in the presence of the 2D-CSx-NH2-HPW catalyst was investigated, and the sulfur removal efficiency was found to decreases in the following order: DBT > 4,6-DMDBT > BT > n-DDM. The 2D-channel catalyst also exhibits excellent recyclability without significant loss of OADS activity after 10 cycles of reactions. This work provides a strategy for constructing 2D-channel catalysts for efficient desulfurization, demonstrating the potential of 2D-channel materials in catalytic applications.

Preparation of chitosan-like magnetic composite microspheres and their adsorption properties for Cu (II)

The novel magnetic composite microspheres (Fe3O4/HAD-C) coated with Fe3O4 were fabricated by inverse suspension cross-linking method, where glutaraldehyde was used as a crosslinking agent. Magnetic Fe3O4 particles and Hexamethylene Diamine Cellulose was prepared respectively by the chemical coprecipitation method and grafting amino group onto microcrystalline Cellulose. The scanning electron microscope, laser particle size analyzer, X-ray diffractometer, and thermogravimetric analyzer were used to characterize the magnetic Fe3O4/HAD-C composite microspheres. The findings demonstrate that the Fe3O4/HAD-C composite microspheres were spherical and well dispersed with the size range between 0.3 μm and 1.2 μm, and possessed super paramagnetic property with 39.72 emu·g−1. The mass of Fe3O4 in the composite is about 37.11 %. By using an adsorption study, the removal of Cu (II) from heavy metal wastewater by Fe3O4/HAD-C was examined. The findings showed that the composite microsphere made of Fe3O4/HAD-C effectively absorbed Cu (II). The entire adsorption procedure follows the Langmuir isothermal adsorption model and pseudo-second order kinetics. Fe3O4/HAD-C also had high reusability and stability. Even after 5 cycles of adsorption and desorption, Fe3O4/HAD-C still achieve 32.45 mg g−1. Environmentally friendly and effective, the unique magnetic chitosan-like composite microspheres (Fe3O4/HAD-C) developed in this study.