There a plethora of evidence suggesting the role of barrier membranes in bone augmentation at sites of inadequate bone volume and height. Amongst the resorbable membranes, native collagen membranes are the standard treatment for guided regeneration procedures. However, native collagen resorbs rapidly whereas cross linking delays it. Pericardium membranes are multilayered, resulting in prolonged barrier function with the properties of native collagen intact. These membranes have proved their utility in the field of vascular, cardiac, thoracic surgery because of their mechanical and clinical handling properties. However, there very little evidence of bone augmentation with pericardium membranes in the field of dentistry, particularly Implantology. The purpose of this review to discuss the potential applications of these membranes in guided bone regeneration. I. INTRODUCTION Periodontal therapy has almost always focused on the arrest of the disease progress and maintenance of the remaining periodontal support. Treatment to restore periodontal health and achieve restitution of attachment apparatus has varied based on the etiology and encompasses procedures such as root planing, soft tissue curettage and various types of flap procedures, often in combination with the placement of bone grafts or bone substitutes into the defects. Most procedures have merely brought about tissue repair, which signifies replacement of the lost apparatus with scar tissue which does not completely restore the architecture or function of the part replaced. Regenerative procedures currently in use in periodontal therapy have not been able to achieve regeneration in the true sense. There have been reports of gaining new attachment by the formation of new cementum.(1) However; bone formation largely insubstantial or delayed. Melchers hypothesis of selective cell repopulation contributed to the understanding of the mechanics of wound healing. This concept was used further by series of experiments and formed the basis of the biologic principle of Guided tissue regeneration. Guided tissue regeneration (GTR) is used to define procedures wherein regeneration of lost periodontal structures (cementum, periodontal ligament, and alveolar bone) sought via selective cell and tissue repopulation of the periodontal wound. Periodontal literature replete with the research work related to tissue and bone regeneration achieved with GTR. This concept further evolved to a more evolved compartmentalized principle of guided bone regeneration (GBR). The biological basis for guided bone regeneration involves fulfillment of bone growth requirement: establishing stable immobile base, allow for release of growth factors, and finally, preserving the blood supply to the area of defects. The guided bone regeneration promotes bone formation by protection against invasion of competing, non osteogenic tissues with the use of barrier membranes. There are three generation of membranes which includes resorbable membranes like collagen and polylactide-co- glycolide, non resorbable membranes like ePTFE and Gore tex and few other membranes under investigation which includes membranes like alloderm, gelfoam, cargile and pericardium membranes. The purpose of this review to throw light on the potential application of pericardium membranes in GBR. The pericardium a fibroserous sac surrounding the mammalian heart. It has long been used in cardiac repair for reconstruction, valve repair and pericardial closure.(2, 3) Pericardial tissue has exceptional handling characteristics and uniform suture retention. In addition, it nonthrombogenic and naturally resists infection. Xenogenic pericardium commonly derived from bovine, porcine and, less frequently, equine sources. Tissues from these sources are available in large patches, allowing custom configuration to a variety of cardiovascular applications. It largely comprised of collagen fibers and has elastic properties allowing conformity to complex anatomy. (4) Bovine pericardium found its application initially as patches for arterial closure during vascular and cardiac surgery. The native structure of bovine pericardium has three layers: 1) the serosa, the inner thin layer consisting of mesothelial cells; 2) the fibrosa, the thicker layer formed by diversely oriented, wavy bundles of collagen and elastin; and 3) the epipericardial connective tissue layer, the outer layer that partly continuous with the pericardiosternal ligaments.(5) BP widely used in cardiac and thoracic surgery, as bioprosthetic valve leaflets, for repair of intracardiac defects, for repair of diaphragmatic defects, vascular surgery, including general surgery, urologic surgery and ophthalmology. The various beneficial properties promoting the use of