Abstract
The purpose of this study is to evaluate and compare the survival and deformity of a full-thickness skin graft over the flap prelaminated by Gore-tex (ePTFE, expanded polytetrafluoroethylene, Gore-tex Soft Tissue Patch, Gore & Assoc Inc, Flagstaff, AZ, USA) in Spraque-Dawley (S-D) rats. The materials were implanted subcutaneously for prelamination of a 2-, 4-, and 6- week period. A pedicle flap enveloping the implant was then elevated. After applying Biobrane under the composite flap, the harvested full-thickness skin was grafted onto the composite flap. The survival of the FTSG and deformity of synthetic materials were evaluated at the time of one week after skin graft surgery. In this study, the survival of skin graft in the Gore-tex group was about 32%. Microscopically, the Gore-tex scaffold was integrated by fibroneovascular tissue. Based on the survival rate of the skin graft, this study demonstrates that prelamination with Gore-tex can produce a relatively lower survival rate of in-situ skin graft on composite tissue flap, and less implant expulsion was observed. The Gore-tex scaffold allowed growth of fibroneovascular tissue but showed visible deformity. The secondary deformity of the Gore-tex scaffold and lower survival of skin graft neglected the clinical usage of this synthetic flap.
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