Complex wounds present a substantial economic burden on healthcare systems, costing billions of dollars in Europe and the US. The prevalence of complex wounds is a significant patient and societal healthcare concern and cost-effective wound-care management remains unclear. The model compares the following strategies for the wound-types venous, diabetic, arterial and mixed: PluroGel vs. Silver-dressing, Hydrogel-dressing, Medical-honey, Impregnated-dressings and Good-wound-care (GWC). All reimbursed products, corresponding to the reimbursement rule, were considered. Markov-modeling techniques were used to estimate wound healing (=wound closure) according to wound types. The three Markov states included unhealed, healed and death. The model considers treatment changes and relapse. According to treatment specific healing-rates patients may move weekly from the health state “Unhealed” to the “Healed” state. This research utilized the outcomes data of a published 1,036 patient, 10-center clinical-study. A 1-year time horizon was used to determine the number of ulcer-free-weeks and the expected costs of therapies. Healing-rates were derived from a systematic literature review from the medical literature for all wound types and comparators. Cost data represent direct medical costs (2017€) for Austria. The payer’s perspective was adopted and only direct costs of care were considered. Sensitivity analyses were performed to gauge model parameter uncertainty. In all wound types PluroGel is associated with the lowest costs. In venous wounds PluroGel costs amount to 3,771€ (silver-dressings: 4,644€; hydrogel-dressings: 4,538€; medical-honey: 4,676€; impregnated-dressings: 4,324€; GWC: 6,764€). With PluroGel, patients reach the median healing-rate after 17 weeks. All comparators need prolonged healing-time (silver-dressings: 21 weeks; hydrogel-dressings: 21 weeks; medical-honey: 19 weeks; impregnated-dressings: 21 weeks; GWC: 22 weeks). Ulcer-free-weeks of PluroGel account for 31 weeks. All treatment alternatives show significantly fewer ulcer-free weeks (24.5 to 27.5 weeks). From the Austrian health-care-systems perspective PluroGel is the most cost-effective wound care product and yield potential cost-savings.