Abstract
INTRODUCTION: Mixed connective tissue disorder, unlike other connective tissue disorders have a milder course. MTCD with only necrotizing cutaneous vasculitis without organ damage respond well to Immunosuppresents and Steroids. CASE REPORT: Middle aged Young lady presented with multiple non healing large pressure sores and multiple nonblanchable purpuric lesions. She was bedridden, anaemic and with significant weight loss. All her major organ functions were normal. Her U1 RNP Antibody is positive and Skin Biopsy showed positive direct fluorescent test for IgG. She responded well to immunosuppresants and steroids. CONCLUSION: This patient who presented with MTCD, with predominant necrotizing cutaneous vasculitis and without major organ involvement showed good recovery and responded well to cyclophosphamide pulse therapy, daily azathioprine and good wound care.
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