Gonadal Stromal Tumors Research Articles

Hilar cell tumour of the ovary.

The case of a 42-year-old woman with virilization, hirsutes, and a high level of circulating testosterone is described. A hilar cell tumour of the ovary was found, the histological features of which were typical, with the presence of crystalloids of Reinke, hyaline bodies, lipid, and lipofuscin. Some areas showed appearances similar to those seen in ;adrenocortical cell' tumours. In common with other lipid cell tumours of the ovary, hilar cell tumours most probably arise from mesenchymal elements and the group should, therefore, be considered as a subdivision of the gonadal stromal (sex cord-mesenchymal) tumours.

Comparative pathology of ovarian neoplasms: IV. Gonadal stromal tumours of canine species

The clinical and pathological features of 26 neoplasms derived from ovarian stroma of canine species were analysed. Three types were identified: (1) granulosa tumours, (2) neoplasms with a Sertoli pattern, and (3) a heterogeneous group regarded simply as nonspecific gonadal stromal tumours. All three types of neoplasm were found in mature dogs. Hyperoestrinising effects occurred in five animals (33 per cent.) of the granulosa group, three (50 per cent.) with Sertoli tumours and four (80 per cent.) of those with nonspecific gonadal stromal tumours. Granulosa tumours were clearly malignant, as three (20 per cent.) had spread beyond the ovary, in contrast to the neoplasms of the other two groups, none of which had metastasised. Tumours with a Sertoli pattern were closely related to granulosa tumours, as they were composed of cells similar to granulosa cells at the periphery of developing follicles and within some atretic follicles of the canine ovary. There were also overlapping patterns with granulosa tumours. Leydig cells and androgenic effects were absent. The neoplasms in this study were compared with tumours of other mammalian species from the standpoint of frequency, morphological pattern and behaviour.

Interstitial Cell Tumor of the Testis: Case Report and Review of the Literature

No AccessJournal of Urology1 Apr 1970Interstitial Cell Tumor of the Testis: Case Report and Review of the Literature G. Bruce Hopkins G. Bruce HopkinsG. Bruce Hopkins Current address: Department of Clinical Pathology, University of Oregon Medical School, Portland, Oregon 97201. More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)61979-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1970 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByCastle W and Richardson J (2018) Leydig Cell Tumor and Metachronous Leydig Cellhyperplasia: A Case Associated With Gynecomastia and Elevated Urinary EstrogensJournal of Urology, VOL. 136, NO. 6, (1307-1308), Online publication date: 1-Dec-1986.Marshall F, Kerr W, Kliman B and Scully R (2018) Sex Cord-Stromal (Gonadal Stromal) Tumors of the Testis: A Report of 5 CasesJournal of Urology, VOL. 117, NO. 2, (180-184), Online publication date: 1-Feb-1977.Newell M, Lippe B and Ehrlich R (2018) Testis Tumors Associated with Congenital Adrenal Hyperplasia: A Continuing Diagnostic and Therapeutic DilemmaJournal of Urology, VOL. 117, NO. 2, (256-258), Online publication date: 1-Feb-1977. Volume 103Issue 4April 1970Page: 449-451 Advertisement Copyright & Permissions© 1970 by The American Urological Association Education and Research, Inc.MetricsAuthor Information G. Bruce Hopkins Current address: Department of Clinical Pathology, University of Oregon Medical School, Portland, Oregon 97201. More articles by this author Expand All Advertisement PDF DownloadLoading ...

Sertoli Cell Tumor (androblastoma): A Case Report

No AccessJournal of Urology1 Aug 1968Sertoli Cell Tumor (androblastoma): A Case Report Lawrence D. Seymour, George Lightbourn, and Beaumanoir Prophete Lawrence D. SeymourLawrence D. Seymour More articles by this author , George LightbournGeorge Lightbourn More articles by this author , and Beaumanoir PropheteBeaumanoir Prophete More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)62501-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1968 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByMarshall F, Kerr W, Kliman B and Scully R (2018) Sex Cord-Stromal (Gonadal Stromal) Tumors of the Testis: A Report of 5 CasesJournal of Urology, VOL. 117, NO. 2, (180-184), Online publication date: 1-Feb-1977.Siller J and Farah R (2018) Androblastoma (Sertoli-Cell Tumor)Journal of Urology, VOL. 106, NO. 4, (565-567), Online publication date: 1-Oct-1971. Volume 100Issue 2August 1968Page: 179-182 Advertisement Copyright & Permissions© 1968 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Lawrence D. Seymour More articles by this author George Lightbourn More articles by this author Beaumanoir Prophete More articles by this author Expand All Advertisement PDF DownloadLoading ...

Feminizing tumours of the testis.

Certain tumours of the testis in man cause symptoms of a feminizing nature and arouse interest and comment out of all proportion to the frequency of their occurrence. Although these tumours are rare, the literature is extensive, as most of the cases tend to be reported, and their hormonal effects have been the subject of much conjecture and speculation. Despite all that has been written, this particular aspect of hormone abnormality still remains ,obscure and complicated. Some authors have introduced new nomenclature and have attempted to classify the tumours from the standpoint of morbid histological studies; but mere histology alone is no basis for classification of these rare and interesting neoplasms. Until they are more fully investigated any attempt at classification is premature, and no real progress can be made in their elucidation. Such investigations must not only be from an histological point of view, but must also include pre-operative and post-operative hormonal assays and biosynthetic studies incorporating tumour tissue. Mostofi et al.,24 in a recent and authoritative article, describe a group of tumours characterized by a wide variety of histological appearances arising from the primitive gonadal mesenchyme. They call these neoplasms ' specialized gonadal stromal tumours'. In a small proportion of their cases gynaecomastia, as evidence of feminization, was reported. This article does much to simplify matters and dispenses with some misleading nomenclature which has been used in the past. These authors have vast experience and almost unlimited material to call upon from the American Armed Forces Institute of Pathology. A further article by them on the subject of interstitial cell tumours of the testis is eagerly awaited and will undoubtedly make a further contribution towards the elucidation and further study of these fascinating tumours.

Tumors of specialized gonadal stroma in human male patients. Androblastoma, Sertoli cell tumor, granulosa-theca cell tumor of the testis, and gonadal stromal tumor.

Tumors of specialized gonadal stroma in human male patients. Androblastoma, Sertoli cell tumor, granulosa-theca cell tumor of the testis, and gonadal stromal tumor.