Reasonable Goal Research Articles

DOP065 SRB1: a Best-in-Class CCR9 depleting antibody that restores immune homeostasis in IBD patients

Abstract Background Inflammatory bowel disease (IBD) is a complex disease characterized by the dysregulation of multiple factors, including host immunity. The intestinal activation of T cells showing cytotoxic activity and pro-inflammatory cytokine production is one of the key factors in its pathology. Therefore, targeting pro-inflammatory leukocytes from the circulation and in the inflammatory site is a reasonable therapeutic goal. CCR9 is the main activator of gut-tropism in the lymphocytes and responsible for the activation of migratory responses in lymphocytes into the lamina propria. SBR1 is a humanized IgG1 anti-CCR9 mAb showing high-affinity and specific binding towards CCR9+ cells. Displaying effector functions such as Antibody-Dependent Cellular Cytotoxicity (ADCC) and Antibody-Dependent Cellular Phagocytosis (ADCP), SRB1 shows specific depletion of infiltrating and circulating CCR9+ cells in vivo and restores the immune homeostasis in patient samples of Crohn’s Disease and Ulcerative Colitis. Methods Matching blood and 5 mm gut explants were obtained from IBD patients, then they were cultured for 16h with SRB1 and subsequently, CCR9+ cells were characterized by flow cytometry. The culture supernatants from these explants as well as blood samples from the same patients were analyzed for pro-inflammatory cytokine production by Multiplex cytokine immune assay. Finally, in non-human primates (Macaca fascicularis) CCR9 cell depletion was determined by flow cytometric assays at doses of 8, 15 y 25 mg/kg. Results We showed that CCR9 is highly expressed in intestine samples from IBD patients, especially in T cells, but also in other cell types including dendritic cells, macrophages and neutrophils. Treatment with SRB1 was able to effectively deplete CCR9+ cells, specifically T CD4+ CCR9+ and CCR9+ memory T cells from blood and intestinal samples from IBD patients. This depletion also reduced the pro-inflammatory cytokine levels in the culture media. Finally, SRB1 also showed efficacy depleting CCR9 in non-human primates (Macaca fascicularis) at different doses without showing any secondary adverse effects. All these data suggest a potential therapeutic potential of the antibody in the pathogenesis of IBD patients. Conclusion SRB1 delivers potent blood and tissue depletion of CCR9 expressing cells ex vivo and in vivo and restores the immune homeostasis in patients’ samples of Crohn’s Disease and Ulcerative Colitis. These data demonstrate the therapeutic potential of SRB1 (anti-CCR9 mAb) a novel therapeutic approach for Inflammatory Bowel Diseases including CD and UC.

Goal Achievement and Academic Dropout Among Italian University Students: The Mediating Role of Academic Burnout.

As stated by the Goal Orientation Theory, students want to achieve a goal for multiple reasons, with each having a different impact on academic performance. This framework encompasses a three-factor model of goal achievement: a mastery goal, a performance-avoidance (PAv) goal, and a performance-approach (PAp) goal. Students may experience elevated stress levels and burnout due to adopting an ineffective approach to goal achievement. This can lead to a loss of interest in studies and even physical and psychological exhaustion. In severe cases, this may result in students abandoning their studies early. This study aims to integrate these factors into a comprehensive model. A cross-sectional study comprising 1497 Italian university students examined the mediating role of academic burnout (professional efficacy, cynicism, and emotional exhaustion) in the association between achievement goals (mastery, PAv, and PAp goals) and the intention to drop out (ID). The questionnaires were administered from October 2022 to September 2023. Structural equation modeling was employed to evaluate the association between variables. The results of the mediation analysis indicate that cynicism and professional efficacy fully mediate the association between mastery and dropout. Cynicism (β = -0.28, p < 0.001) and professional efficacy (β = -0.17, p < 0.001) were both negatively associated with ID, while they partially mediate the association between PAv goals and ID (cynicism: β = 0.21, p ≤ 0.001; professional efficacy: β = 0.05, p ≤ 0.001), and between PAp goals and ID via professional efficacy (β = -0.04, p ≤ 0.001). This study contributes to the currently limited literature on the relationship between achievement goals, burnout, and ID in a sample of university students. The findings of this study may have useful implications for the application of interventions that impact students' well-being and academic success, potentially limiting their possible dropout.

Examining the Effects of Different Types of Achievement Goal Orientation on Undergraduate Students' Engagement in Distance Learning: The Mediating Effect of Self-Efficacy.

This study investigates the impact and mechanisms of achievement goal orientation on online learning engagement among undergraduates, using a sample of 461 students enrolled in online courses from four universities of varying levels in Shanghai, China. Self-efficacy is introduced as a mediating variable, and structural equation modeling is employed to assess the effects. The findings reveal that different types of achievement goals have varying natures and intensities in their associations with undergraduate online learning engagement. Self-efficacy partially mediates the effect of mastery-approach goals on online learning engagement, but does not mediate the effects of mastery-avoidance, performance-approach, or performance-avoidance goals. The study recommends leveraging the guiding role of mastery-approach achievement goals to help students set scientific and reasonable goals, and stimulating students' self-efficacy through the dual influences of external support and internal motivation. With the support of these strategies, significant improvements in undergraduate online learning engagement can be achieved.

Using Time in Tight Glucose Range as a Health-Promoting Strategy in Preschoolers With Type 1 Diabetes.

Children who develop diabetes in their first years of life risk being exposed to many decades of hyperglycemia, hence having a high risk of early complications and premature death. An additional age-dependent risk is that dysglycemia, especially hyperglycemia, negatively affects the developing brain. In evaluating the outcome of insulin treatment at an individual and group level, cutoff thresholds for glucose values are needed. Time in tight range (TITR) was defined as a measurement of time spent in a state of normoglycemia. The International Society of Pediatric and Adolescent Diabetes recommended that for preschoolers with type 1 diabetes (T1D), either >70% of time with glucose in range 70-180 mg/dL (3.9-10 mmol/L) or >50% of time in a tighter range 70-140 mg/dL (TITR) can be used as continuous glucose monitoring targets. In Sweden, over the past two decades, pediatric diabetes teams set glycemic targets to 70-140 mg/dL (3.9-7.8 mmol/L). Swedish registry data show that >50% of children <7 years old have >50% TITR. The purpose of this review is to share and discuss international knowledge and experiences of working with TITR as a health-promoting strategy in preschoolers with T1D on a structural and individual level. We conclude that as insulin treatment improves, a reasonable goal is to strive for as much time in a state of normoglycemia as possible, and this can easily be explained to families of children with diabetes. For children with access to an experienced health care team and diabetes technologies a currently realistic target can be at least half of the time in normoglycemic range, i.e., TITR >50%.

Abstract Su502: Is 80% a Reasonable Minimal Goal for Defibrillation Efficacy of Out-of-Hospital Cardiac Arrest ?

Introduction: There is no clear goal defined by standards or learned societies on clinical performance related to defibrillation efficacy. In literature, monophasic shocks defibrillation efficacy is mainly &gt;70% whereas biphasic is &gt;80%. Resuscitation guidelines define efficient defibrillation as cessation of shockable rhythm at 5s post-shock and proceed to state that beyond 5s, shock outcomes are biased by known confounders (call to AED connection time (CallAEDTime), bystander, cardio-pulmonary resuscitation (CPR), drugs…). Thus, it is consistent that automated external defibrillator (AED) performance should be assessed in terms of defibrillation efficacy right after the shock rather than in terms of restoration of a spontaneous circulation or survival to hospital discharge. This study aimed to define an acceptable goal for validation of defibrillation efficacy. Method: In this observational retrospective study, we included AED tracings of adult non-traumatic out-of-hospital cardiac arrest (OHCA) patients with initial ventricular fibrillation (VF) rescued by basic life support teams (Paris Fire Brigade) from 01/2017 to 02/2022. Cardiac rhythm was examined during the 10 first minutes of connection of the AED (DGT7, Schiller Médical, France). Shockable rhythm is defined as coarse-VF with at least 200µV peak-to-peak amplitude (ptpA). Efficient defibrillation was defined as cessation of shockable rhythm at 5s post-shock. We fitted a linear mixed model to predict defibrillation efficacy using the 4s ptpA of pre-shock VF. The model included the patient as random effect and a p-value &lt;0.05 was considered statistically significant. Results: We analyzed 1333 shocks from 547 patients, with: median age of 59 (interquartile range, IQR[49-71]), 78% male, 36% in public places, 72% with bystander CPR and median[IQR] CallAEDTime of 13min [10-15]min. The effect of the pre-shock ptpA of VF on the defibrillation efficacy is statistically significant: OR=1.023, 95% Confidence Interval (CI) [1.010,1.036], p&lt;0.001. That means that for each 100µv increment in VF amplitude pre-shock, the probability of success at 5s post-shock increases by 2.3%. Adjusting for age, sex, location, CPR and CallAEDTime does not change the results. The logistic regression of Figure1, shows a defibrillation efficacy at 200µV ptpA of 79%, CI [75,82]%. Conclusion: Based on 1333 OHCA biphasic shocks, this study suggests defining 80% as a reasonable minimal goal for validation of the AED defibrillation efficacy.

A rate-them-all lineup procedure increases information but reduces discriminability.

Prior research has investigated ways to optimize identification performance, but an open question concerns exactly what variable should be optimized. One reasonable way to optimize performance is to maximize discriminability, which is achieved by increasing correct identifications of guilty suspects while simultaneously decreasing false identifications of innocent suspects. Another reasonable way to optimize performance is to maximize the information about the guilt or innocence of the suspect, which is best achieved by ensuring that a confidence rating is always made to the suspect. In a typical lineup, however, limited information about the suspect is obtained if the witness picks a filler or rejects the lineup. One proposed solution to that problem is to have the witness provide a confidence rating to every member of the lineup (a rate-them-all lineup). But what effect, if any, does a rate-them-all procedure have on discriminability? To answer that question, we compared a rate-them-all lineup procedure to standard simultaneous lineup and showup procedures using receiver operating characteristic analysis. In terms of discriminability, the rate-them-all procedure was diagnostically inferior to both. A reasonable goal for future research is to make use of theoretical models of eyewitness identification to simultaneously maximize both discriminability and information gain. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Management Strategies for Children and Adolescents with Diabetes Mellitus

The principles of treatment for diabetes in children and adolescents cannot simply be derived from care routinely provided to adults with diabetes. The major consideration is that the epidemiology, pathophysiology, developmental considerations, and response to treatment of pediatric diabetes are often different from those of adult diabetes. Second, recommended treatments for children and adolescents with type 1 diabetes (T1DM), type 2 diabetes (T2DM), and other pediatric conditions such as monogenic diabetes (neonatal diabetes and MODY [maturity-onset diabetes of the young]) also differ. HbA1c goals in T1DM and T2DM must be individualized and reassessed over time. A HbA1c &lt; 7% is appropriate for many children and adolescents with T1DM. In a case with hypoglycemia, hypoglycemic unawareness, lack of access to analog insulins, advanced insulin delivery technology and/or continuous glucose monitoring, a less stringent HbA1c &lt; 7.5% will be required. A reasonable HbA1c goal for T2DM is &lt; 7%. If possible, a strict HbA1c target of &lt; 6.5% can be implemented. Metformin is the first-line treatment of choice in T2DM. In a case with ketosis or HbA1c &gt; 8.5%, insulin will be required with once daily basal insulin (0.25~0.5 IU/kg). If the glycemic goal is not attained, the addition of a second agent is considered in adult patients but might not be applicable or safe in pediatric cases. Therefore, the efficacy and safety of these drugs used in adult patients, including glucagon-like peptide-1 receptor agonists and sodium glucose cotransporter 2 inhibitors, should be evaluated in pediatric patients worldwide.

Cyanocobalamin-loaded dissolving microneedles diminish skin inflammation in vivo

Inflammatory diseases of the skin have a considerable high prevalence worldwide and negatively impact the patients' quality of life. First-line standard therapies for these conditions inherently entail important side effects when used long-term, particularly complicating the management of chronic cases. Therefore, there is a need to develop novel therapeutic strategies to offer reliable alternative treatments. Abnormally high reactive oxygen species (ROS) levels are characteristic of this kind of illnesses, and therefore a reasonable therapeutic goal. Cyanocobalamin, also known as Vitamin B12, possesses notable antioxidant and ROS-scavenging properties which could make it a possible therapeutic alternative. However, its considerable molecular weight restricts passive diffusion through the skin and forces the use of an advanced transdermal delivery system. Here, we present several prototypes of Cyanocobalamin-loaded Dissolving Microarray Patches (B12@DMAPs) with adequate mechanical properties to effectively penetrate the stratum corneum barrier, allowing drug deposition into the skin structure. Ex vivo penetration and permeability studies noted an effective drug presence within the dermal skin layers; in vitro compatibility studies in representative cell skin cell lines such as L929 fibroblasts and HaCaT keratinocytes ensured their safe use. The in vivo efficacy of the selected prototype was tested in a delayed-type hypersensitivity murine model that mimics an inflammatory skin process. Several findings such as a reduction of MPO-related photon emission in a bioluminescence study, protection against histological damage, and decrease of inflammatory cytokines levels point out the effectivity of B12@DMAPs to downregulate the skin inflammatory environment. Overall, B12@DMAPs offer a cost-effective translational alternative for improving patients' skin healthcare.

Effect of kyron T-134 and crospovidone as a fast disintegrating agent on formulation properties of fast dissolving tablet containing ketorolac and rizatriptan using direct compression method

Background and objective: Fast dissolving tablets (FDTs) are "they are uncoated tablets that are supposed to be placed in the mouth and dispersed quickly before being swallowed" within minutes. This study aimed to formulate and evaluate a combination of ketorolac and rizatriptan as orally fast-dissolving tablets using the most common and easiest method to treat migraine attacks with or without aura. To investigate the effects of various types of diluents and super disintegrants on wetting time, water absorption ratio, disintegration, and dissolution time of combined drugs (ketorolac and rizatriptan) as oral dissolving tablets prepared by direct compression technique. Methods: Pre-formulation experiments were carried out in order to rule out any physicochemical interactions between the two medications (ketorolac and rizatriptan) as well as between each drug and its excipients. Four different formulations of fast-dissolving tablets with different types and ratios of diluents and super disintegrants were created using the direct compression technique in order to improve the formulation. Organoleptic characteristics, weight variation, thickness, friability, hardness, disintegration duration, wetting duration, water absorption ratio, drug content, in-vitro dissolution, stability, and comparison tests have all been characterized. Results: According to FT-IR, the two drugs and excipients exhibit no physicochemical interactions. The ideal formula F4 contains crospovidone and Kyron T-134 at optimal concentrations of 2.5% and 2.5%, respectively, and provides the majority of pharmaceutical drugs to be released within the first five minutes, a strong stability profile, the shortest wetting time with the fastest disintegration time (10 sec), and a pleasant flavor (strawberry flavoring agent). Conclusion: Kyron T-134 with Crospovidone in a (1:1) ratio provided rapid disintegration. Ketorolac tromethamine and rizatriptan benzoate may be made into fast-dissolving oral tablets using Kyron T-134 and Crospovidone. Improving migraine compliance is a reasonable goal.

Retaining Employees in Indian Private Banking Sector

The Indian banking industry is growing fast and needs talented workers. One of the biggest challenges for banks is recruiting and retaining staff. India's private banks are witnessing a spike in attrition rates, especially among younger, frontline staff. Research on retention strategies and banking industry factors is scarce for private banks. Employee retention strategies in select private banks in greater are studied. HDFC and ICICI banks are among the top five private banks surveyed. It identifies the retention factors and processes that influence employees' decisions to stay with the bank, analyses the similarities in retention strategies across select private banks, groups the banks by similarities, and interprets the relationship between demographics and satisfaction with banks' retention efforts. Descriptive statistics and single proportion test, ANOVA, Chi-square, Rank sum method, Post Hoc test, and paired comparison are used to analyse primary data. Salary, training and development, bonuses, workplace relations, and Medi-claim benefits influence private sector bank employees' decisions to stay. Bank employees expect rewards for their work, reasonable goals, and better communication to stay motivated and work there.

Distribution, source apportionment and ecological risk assessment of heavy metals in Limbe River sediments, Atlantic Coast, Cameroon Volcanic Line

The objective of this research was to assess sediments contamination, provenance and metal pollution using single and complex pollution indicators. Limbe River sediment samples were analysed using Inductively Coupled Plasma—Mass Spectrometry. The Limbe River sediments exhibit high content in Fe2O3 sourced from haematization of basaltic rocks. The concentration of Cd, Co, Cr, Mn, Ni, Pb, Sn, Sr, V and Zn exceed upper continental crust and local baseline values for heavy metals. Correlation matrix analysis indicates the presence of common input sources and similar geochemical characteristics of heavy metals. Contamination factor (CF: 0.01–10.34), contamination degree (Cdeg: 14.91–36.57), pollution load index (PLI: 0.84–1.77), and nemerow integrated pollution index (NIPI: 0.2–1.7) indicates significant to high levels of contamination. The enrichment factor (EF: 0–5.67) and geo-accumulation index (Igeo: -7.55–2.59), suggests moderate to significant metal pollution of the Limbe River ecosystem, suggesting potential ecological effects. Modified hazard quotient (mHQ: 0.082–6.35) and toxic risk index (TRI: 10.49–27.43), indicates low to extreme pollution severity and high toxicity risks of heavy metals to the aquatic ecosystem fauna and flora. Primarily anthropogenic activities and secondary lithogenic provenance is attributed to sediments contamination and metals pollution. This study suggests that a greater emphasis should be placed on monitoring various provenances of metals entering the aquatic ecosystem from anthropogenic practices. The study emphasizes the significance of continual protection of aquatic ecosystem and biological resources and adaptive management. The development of reasonable goals for monitoring and remedial programmes can be aided by this data.

Setting reasonable goals for kidney transplant referral among dialysis facilities

BackgroundDetermining whether a patient is eligible for kidney transplantation is complex. In this study, we estimate what proportion of patients with end-stage kidney disease (ESKD) might have been suitable candidates for kidney transplantation but were not referred.MethodsWe identified 43,952 people initiating dialysis for kidney failure between 2012 and 2017 in the states of Georgia, North Carolina, or South Carolina from the United States Renal Data System and linked to the Early-Steps to Transplant Access Registry to obtain data on referral and waitlisting up until December 2020. We identified ‘good transplant candidates’ as those who were waitlisted within 2-years of referral, among all patients referred within 1-year of dialysis initiation. Using propensity score cut-offs, logistic regression, and area under the curve (AUC), we then estimated the proportion of individuals who may have been good transplant candidates, but were not referred.ResultsOverall, 42.6% of incident dialysis patients were referred within one year and among them, 32.9% were waitlisted within 2 years of referral. Our model had reasonably good discrimination for identifying good transplant candidates with an AUC of 0.70 (95%CI 0.69–0.71), sensitivity of 0.68 and specificity of 0.61. Overall, 25% of individuals not referred for transplant may have been ‘good’ transplant candidates. Adding these patients to the existing 18,725 referred patients would increase the proportion of incident ESKD patients being referred within one year from 42.6% to 57.2% (a ~ 14.6% increase).ConclusionsIn this study, we show that a significant proportion of potentially good transplant candidates are not being referred for transplant. A ~ 14% increase in the proportion of patients being referred from dialysis facilities is both a meaningful and realistic goal and could lead to more qualified patients being referred and subsequently waitlisted for a lifesaving transplant.

Formation of the prestige of the teaching profession in the system of secondary vocational education

Secondary vocational education (SPE) occupies a significant position in the education system of the Russian Federation. In modern society, there is a need for multi-level education systems that can provide competent and competitive specialists in the labor market. As a result, getting a high-quality education becomes a clear and reasonable goal for both the younger generation and adults. The quality of education remains one of the key factors for the successful development of the country. Progress in various fields, such as technology, economics, informatization, education and society as a whole, directly depend on it. SPE plays an important role in the training of a skilled workforce that meets the needs of various sectors of the economy. It aims to provide students not only with professional knowledge and skills, but also with the formation of general cultural competencies. The importance of vocational education lies in the fact that it ensures the socio-economic mobility of the population, promotes the integration of graduates into society and increases their social status. However, the implementation of effective and high-quality vocational training for students of secondary vocational education is faced with a number of problems. Some of them include the need to update educational programs in accordance with modern requirements of the labor market, strengthening the practical component of training, improving the professional competence of the teaching staff, the introduction of information and educational technologies and the development of career guidance. Solving these problems requires the joint efforts of the State, the public, employers and professional educational institutions. Thus, the development of high-quality education in secondary education remains an urgent task affecting national development as a whole.

Who gets the money? A qualitative analysis of fintech lending and credit scoring through the adoption of AI and alternative data

Credit scoring plays an important role in determining the accessibility of credit in the financial sector. This in turn has a significant impact on how economic opportunities are distributed. Our study examines the use of AI and alternative data in fintech lending through the lens of Information Asymmetry Theory. By employing a qualitative research design using the Gioia method, we extract, analyze, and synthesize insights from a diverse group of 26 experts in fintech lending, artificial intelligence, machine learning, data science, and academia. Our results reveal several important findings: the enhancement of predictive proficiency and risk management, the decrease in default rates, the extension of credit access by including previously ‘unbanked populations’, the introduction of real-time creditworthiness assessment and new business models for entrepreneurs, the enhancement of credit market efficiencies and positive effects on the stability of financial markets. In addition, our study highlights the necessity for rigorous and critical ethical considerations of important challenges such as the question of consent, algorithmic transparency, data quality, data misuse, representativeness, traceability, responsibility, bias and discrimination. The reasonable goal of a more fair, resilient, sustainable and accessible credit system will require a joint effort to balance leveraging technological innovations with respecting peoples' right to privacy.

Analysis of The Performance Appraisal &amp; Bonus Payments at Real Ispat

The goal of the research project "Analysis of The Performance Appraisal &amp; Bonus Payments at Real Ispat" is to examine the complex workings of performance assessment systems and how they affect worker satisfaction, productivity, and motivation. Acknowledging the pivotal function that incentive payments and performance reviews play in molding organizational results, this study attempts to offer a thorough examination of these mechanisms in the context of Real Ispat, a prominent participant in the steel production industry. This study's primary goal is to examine how performance reviews affect workers' motivation and output. Performance reviews are meant to provide workers input on how they perform at work, point out their areas of strength and weakness, and establish goals for the future. This study investigates the relationship between these evaluations and workers' incentive to improve performance and total output. Through gathering information from workers at different levels, the study seeks to measure how much performance reviews impact employee engagement and productivity, which in turn boosts the effectiveness and production of the company. Finding out how employees feel about and are satisfied with the performance evaluation process is the second goal. The success of the system depends heavily on how fair, transparent, and successful the assessment process is by the workforce. This survey looks at how Real Ispat employees feel about the assessment process, whether they think it's fair and impartial, and if they're happy with how often these appraisals are done. Since these impressions have a direct influence on employee morale, engagement, and retention, it is important to understand them. Evaluating the efficacy of Real Ispat's present performance evaluation system is the third goal. This entails determining whether the system of appraisals successfully identifies top performers and appropriately represents the work performance of employees. The study also looks at the impact that appraisals have on career development and how they help define reasonable and attainable performance goals. It also looks for areas where the assessment system needs to be improved in order to better fit with employee expectations and company goals. The study uses a mixed-method approach, integrating quantitative and qualitative data-gathering approaches, to accomplish these goals. Likert scale surveys are used to collect quantifiable information about worker productivity, satisfaction, motivation, and views. To obtain qualitative insights into employees' experiences and ideas for improvement, focus groups, and in-depth interviews are held. It is anticipated that the study's conclusions will give Real Ispat's management insightful information that will help them improve their processes for incentive payments and performance reviews. The organization may improve employee motivation, contentment, and productivity by implementing focused interventions after determining the present strengths and weaknesses of these systems. This study also adds to the larger body of knowledge on performance reviews by presenting best practices that other companies may use and providing actual data from the manufacturing industry. Finally, the "Analysis of The Performance Appraisal &amp; Bonus Payments at Real Ispat" hopes to establish a standard for other businesses looking to optimize their performance assessment procedures in addition to improving Real Ispat's internal operations. This research aims to promote a more driven, productive, and contented workforce—which will eventually drive corporate success and growth—through thorough analysis and practical recommendations. Submit Research Paper Submit Research Paper Publication Procedure Publication Ethics Call for Papers Publication Topics Guidelines Disclamiar Copyright Infragmentation FAQ Terms and Conditions Digital Object Identifier Editorial Board Health Care+ Download Manuscript Template Copyright Form Sample Certificates

175 Benchmarking MICHR’s Clinical and Translational Science production as a continuous quality improvement initiative.

OBJECTIVES/GOALS: In line with NCATS funding requirements, the Michigan Institute for Clinical and Health Research (MICHR) established a continuous quality improvement (CQI) process and used the process to guide the implementation of a benchmarking project to evaluate and set goals for MICHR’s production of Clinical and Translational Science manuscripts. METHODS/STUDY POPULATION: We aimed to increase the number of Clinical and Translational Science papers MICHR produces and to set a reasonable goal for improvement. Benchmarking was used to obtain a baseline and inform the identification of a reasonable goal for improvement. 11 Peer institutions were identified with similar funding levels. 1,225 Publications from 2022 for all 12 CTSAs were obtained from NIH Reporter. All publications were reviewed by title to identify probable CTS content. Two staff reviewers confirmed a total of 108 CTS publications across all CTSAs, and coded each paper to characterize the theoretical approach, method (quantitative and/or qualitative), analytic method and topic. All publications that were selected for benchmarking were also tracked and compared using Altmetrics for Institutions and Overton platforms. RESULTS/ANTICIPATED RESULTS: A total of 108 CTS publications were produced by 12 benchmarked CTSAs in 2022; of those, 70% (77) regarded research infrastructure, 37% (41) regarded research methods, and 15% (16) regarded clinical care. Over half, 53% (58), of the benchmarked papers are empirical research papers; of those, 67% (39) used quantitative methods, 28% (16) used qualitative methods, and 5% (3) used mixed methods. A clear majority of the benchmarked papers, 70% (76), provided only descriptive analyses, 18% (19) provided inferential analyses, and 12% (13) provided predictive analyses. We identified an opportunity to produce more manuscripts with descriptive analyses of research infrastructure. In the long-term, we saw an opportunity to produce predictive analyses of translational initiatives designed to impact clinical care. DISCUSSION/SIGNIFICANCE: The benchmarking results helped MICHR identify goals for its production of Clinical and Translational Science to fill gaps in the field. Expanding the scope of this benchmarking project might achieve greater interrater reliability using larger representative sets of publications drawn from institutions across the CTSA Consortium.

Emission Prediction, Global Stocktake, and NDC Update: CO-STIRPAT Dynamic System

This analysis proposes a prediction framework for estimating the probability of fulfilling nationally determined contributions (NDC). The framework using conventional empirical methodology (CO-STIRPAT, bootstrapping sampling, and system dynamics) is employed to project the paths of carbon emissions up to 2030. When the approach is applied to data in the Republic of Korea (ROK) presents that the effect of increasing the share of green energy alone may not be enough to achieve the NDC target by 2030. Additional efforts are required to adopt advanced climate technologies related to carbon intensity and energy efficiency, given the predicted economic conditions until 2030. Alternatively, it may be appropriate for the ROK to slow down the pace at which it raises its NDC. Our prediction framework can provide information that can motivate countries to reevaluate whether the ambition level of its target is compatible with the projected economic conditions and to set more reasonable goals in their subsequent NDCs.

Research on the path to enhance the cultural communication literacy of Thai international Chinese language teachers

With the rapid development of global integration, new requirements have been put forward for the content of communication and cooperation among countries. Since the 1990s, China's comprehensive strength has continued to develop rapidly and has become an indispensable and important country in the global development process. With China's increasing international status and close cooperation with countries around the world in multiple fields, each country has a strong demand for learning Chinese, which has prompted China's Chinese language and culture to enter a new stage of high-quality development. Language is a bridge of communication that can promote the integration and development of international culture, industry, and other aspects. International Chinese language teachers play a particularly important role in the dissemination of Chinese language and literature. Therefore, it is necessary to develop a standardized framework and model for cultivating the ability elements of international Chinese language teachers based on guidance and goals, in order to promote sustainable development. This study uses literature review, interview methods, and mathematical statistics to investigate some international Chinese language teachers who have traveled from China to Thailand. The PDCA cycle theory is used to establish a development path centered on "current situation analysis, innovation path, path evaluation, and continuous improvement", exploring the difficulties and difficulties in improving the cultural communication literacy ability of Thai international Chinese language teachers, Targeted optimization and development paths should be proposed: (1) Reasonable goals and development ideas for cultivating the ability elements of international Chinese language teachers should be formulated based on the actual situation of Thai Chinese language learning, exploring deep internal motivation and logical relationships, and improving the framework for cultivating ability elements based on the elements of communication. (2) In the specific implementation process, specific indicators for cultivating ability elements should be clearly defined to strengthen standardization. Targeted training should be conducted based on relevant indicators. (3) Targeted ability element training standards should be developed for Chinese language teachers based on the actual environment, needs, and theoretical foundation of international communication in Thai Chinese language learning. Fourthly, explore diversified cultural communication methods and development path choices, improve the comprehensive ability of Thai international Chinese language around the elements of global communication, and continuously optimize the curriculum system and teaching content. (4) We should improve the evaluation and feedback system, establish clear management systems and development plans for each stage, and promote excellent culture and concepts in a healthy manner. In the specific implementation process, being good at identifying and proposing problems, and combining practical experience to fully solve problems, can help promote deep development.

A Goal Interaction Graph Planning Framework for Conversational Recommendation

Multi-goal conversational recommender system (MG-CRS) which is more in line with realistic scenarios has attracted a lot of attention. MG-CRS can dynamically capture the demands of users in conversation, continuously engage their interests, and make recommendations. The key of accomplishing these tasks is to plan a reasonable goal sequence which can naturally guide the user to accept the recommended goal. Previous works have demonstrated that mining the correlations of goals from the goal sequences in the dialogue corpus is helpful for recommending the goal that the user is interested in. However, they independently model correlations for each level of goal (i.e., goal type or entity) and neglect the order of goals appear in the dialogue. In this paper, we propose a goal interaction graph planning framework which constructs a directed heterogeneous graph to flexibly model the correlations between any level of goals and retain the order of goals. We design a goal interaction graph learning module to model the goal correlations and propagate goal representations via directed edges, then use an encoder and a dual-way fusion decoder to extract the most relevant information with the current goal from the conversation and domain knowledge, making the next-goal prediction fully exploit the prior goal correlations and user feedback. Finally we generate engaging responses based on the predicted goal sequence to complete the recommendation task. Experiments on two benchmark datasets show that our method achieves significant improvements in both the goal planning and response generation tasks.

Public Reason, Bioethics, and Public Policy: A Seductive Delusion or Ambitious Aspiration?

Can Rawlsian public reason sufficiently justify public policies that regulate or restrain controversial medical and technological interventions in bioethics (and the broader social world), such as abortion, physician aid-in-dying, CRISPER-cas9 gene editing of embryos, surrogate mothers, pre-implantation genetic diagnosis of eight-cell embryos, and so on? The first part of this essay briefly explicates the central concepts that define Rawlsian political liberalism. The latter half of this essay then demonstrates how a commitment to Rawlsian public reason can ameliorate (not completely resolve) many of the policy disagreements related to bioethically controversial medical interventions today. The goal of public reason is to reduce the size of the disagreement by eliminating features of the disagreement that violate the norms of public reason. The norms of public reason are those norms that are politically necessary to preserve the liberal, pluralistic, democratic character of this society. What remains is reasonable disagreement to be addressed through normal democratic deliberative processes. Specific issues addressed from a public reason perspective include personal responsibility for excessive health costs, the utility of a metaphysical definition of death for organ transplantation, and the moral status of excess embryos generated through IVF and/or their use in medical research.