The ongoing molecular investigation of the basic contractile units of the sarcomere in striated muscles have revealed a highly complex system composed of a large number of proteins each one with a specific task.1 However, a growing number of studies is pointing the attention to the fact that many of these structural proteins may also be involved in pathways and functions other than contraction but always related to muscle cell maintenance, repair, differentiation, signaling, etc.1 In this context an important role has been attributed to the muscle LIM protein (MLP). MLP is a member of the cysteine and glycine rich protein (CSRP) family that is composed by CSRP1, CSRP2 and CSRP3 or MLP. CSPRs, in turn, belong to the larger family of LIM domain proteins.2 MLP is expressed in striated muscle at the level of sarcomere, the intercalated disk and the costamere where it interacts with telethonin, α-actinin, cofilin-2 and calcineurin among others and contains two LIM domains that are zinc finger domains composed of ~55 aminoacids with 8 highly conserved residues, mostly cysteine and histidine that are located at defined intervals.2 Through the LIM domain, MLP can modulate protein interaction and formation of macromolecular structures. Another peculiarity of MLP is that it can shuttle from the cytosol to the nucleus where it serves as a scaffold protein to adapt transcription factors to their DNA-binding sequences.2, 3 In fact, MLP is involved myocyte differentiation by activating transcription factors such as MyoD, myogenin, etc.4 To this effect, mutations in the N-terminal region of MLP have been linked to the development of dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM). Moreover, MLP protein levels or intracellular localization are altered in skeletal myopathies, such as fascioscapulohumeral muscular dystrophy, nemaline myopathy and limb girdle muscular dystrophy type 2B.5, 6 Therefore, the current dogma foresee an important role for MLPin the maintenance of muscle cytoarchitecture as well as in the differentiation of muscle cells. However, the cellular and molecular mechanism(s) through which MLP carries out its function is (are) still obscure.